GenomeNet

Database: UniProt
Entry: A0A337RYI7_FELCA
LinkDB: A0A337RYI7_FELCA
Original site: A0A337RYI7_FELCA 
ID   A0A337RYI7_FELCA        Unreviewed;       729 AA.
AC   A0A337RYI7;
DT   10-OCT-2018, integrated into UniProtKB/TrEMBL.
DT   10-OCT-2018, sequence version 1.
DT   24-JAN-2024, entry version 22.
DE   RecName: Full=Chloride channel protein {ECO:0000256|RuleBase:RU361221};
GN   Name=CLCN4 {ECO:0000313|Ensembl:ENSFCAP00000042524.1,
GN   ECO:0000313|VGNC:VGNC:60926};
OS   Felis catus (Cat) (Felis silvestris catus).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Carnivora; Feliformia; Felidae; Felinae; Felis.
OX   NCBI_TaxID=9685 {ECO:0000313|Ensembl:ENSFCAP00000042524.1, ECO:0000313|Proteomes:UP000011712};
RN   [1] {ECO:0000313|Ensembl:ENSFCAP00000042524.1, ECO:0000313|Proteomes:UP000011712}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Abyssinian {ECO:0000313|Ensembl:ENSFCAP00000042524.1,
RC   ECO:0000313|Proteomes:UP000011712};
RX   PubMed=17975172; DOI=10.1101/gr.6380007;
RA   Pontius J.U., Mullikin J.C., Smith D.R., Lindblad-Toh K., Gnerre S.,
RA   Clamp M., Chang J., Stephens R., Neelam B., Volfovsky N., Schaffer A.A.,
RA   Agarwala R., Narfstrom K., Murphy W.J., Giger U., Roca A.L., Antunes A.,
RA   Menotti-Raymond M., Yuhki N., Pecon-Slattery J., Johnson W.E., Bourque G.,
RA   Tesler G., O'Brien S.J.;
RT   "Initial sequence and comparative analysis of the cat genome.";
RL   Genome Res. 17:1675-1689(2007).
RN   [2] {ECO:0000313|Ensembl:ENSFCAP00000042524.1, ECO:0000313|Proteomes:UP000011712}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Abyssinian {ECO:0000313|Ensembl:ENSFCAP00000042524.1,
RC   ECO:0000313|Proteomes:UP000011712};
RA   Hillier L.W., Warren W., Obrien S., Wilson R.K.;
RT   "Sequence assembly of the Felis catus genome version 6.2.";
RL   Submitted (SEP-2011) to the EMBL/GenBank/DDBJ databases.
RN   [3] {ECO:0000313|Ensembl:ENSFCAP00000042524.1}
RP   IDENTIFICATION.
RC   STRAIN=breed Abyssinian {ECO:0000313|Ensembl:ENSFCAP00000042524.1};
RG   Ensembl;
RL   Submitted (SEP-2023) to UniProtKB.
CC   -!- SUBCELLULAR LOCATION: Endosome membrane
CC       {ECO:0000256|ARBA:ARBA00004337}; Multi-pass membrane protein
CC       {ECO:0000256|ARBA:ARBA00004337}. Membrane
CC       {ECO:0000256|ARBA:ARBA00004141, ECO:0000256|RuleBase:RU361221}; Multi-
CC       pass membrane protein {ECO:0000256|ARBA:ARBA00004141,
CC       ECO:0000256|RuleBase:RU361221}.
CC   -!- SIMILARITY: Belongs to the chloride channel (TC 2.A.49) family.
CC       {ECO:0000256|RuleBase:RU361221}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; AANG04001271; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   AlphaFoldDB; A0A337RYI7; -.
DR   Ensembl; ENSFCAT00000052299.2; ENSFCAP00000042524.1; ENSFCAG00000007631.6.
DR   VGNC; VGNC:60926; CLCN4.
DR   GeneTree; ENSGT00940000158265; -.
DR   Proteomes; UP000011712; Chromosome X.
DR   Bgee; ENSFCAG00000007631; Expressed in prefrontal cortex and 9 other cell types or tissues.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0005247; F:voltage-gated chloride channel activity; IEA:UniProtKB-UniRule.
DR   CDD; cd04591; CBS_pair_voltage-gated_CLC_euk_bac; 1.
DR   CDD; cd03684; ClC_3_like; 1.
DR   Gene3D; 3.10.580.20; -; 1.
DR   Gene3D; 3.90.1280.20; -; 1.
DR   Gene3D; 1.10.3080.10; Clc chloride channel; 2.
DR   InterPro; IPR000644; CBS_dom.
DR   InterPro; IPR046342; CBS_dom_sf.
DR   InterPro; IPR014743; Cl-channel_core.
DR   InterPro; IPR001807; Cl-channel_volt-gated.
DR   InterPro; IPR002246; Cl_channel-4.
DR   PANTHER; PTHR45711; CHLORIDE CHANNEL PROTEIN; 1.
DR   PANTHER; PTHR45711:SF2; H(+)/CL(-) EXCHANGE TRANSPORTER 4; 1.
DR   Pfam; PF00571; CBS; 2.
DR   Pfam; PF00654; Voltage_CLC; 2.
DR   PRINTS; PR00762; CLCHANNEL.
DR   PRINTS; PR01115; CLCHANNEL4.
DR   SMART; SM00116; CBS; 2.
DR   SUPFAM; SSF54631; CBS-domain pair; 1.
DR   SUPFAM; SSF81340; Clc chloride channel; 1.
DR   PROSITE; PS51371; CBS; 2.
PE   3: Inferred from homology;
KW   CBS domain {ECO:0000256|ARBA:ARBA00023122, ECO:0000256|PROSITE-
KW   ProRule:PRU00703};
KW   Chloride {ECO:0000256|ARBA:ARBA00023214, ECO:0000256|RuleBase:RU361221};
KW   Endosome {ECO:0000256|ARBA:ARBA00022753};
KW   Ion transport {ECO:0000256|RuleBase:RU361221};
KW   Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|RuleBase:RU361221};
KW   Reference proteome {ECO:0000313|Proteomes:UP000011712};
KW   Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW   ECO:0000256|RuleBase:RU361221};
KW   Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW   ECO:0000256|RuleBase:RU361221}; Transport {ECO:0000256|RuleBase:RU361221}.
FT   TRANSMEM        68..88
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU361221"
FT   TRANSMEM        153..178
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU361221"
FT   TRANSMEM        199..221
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU361221"
FT   TRANSMEM        227..243
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU361221"
FT   TRANSMEM        255..279
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU361221"
FT   TRANSMEM        291..308
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU361221"
FT   TRANSMEM        337..354
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU361221"
FT   TRANSMEM        410..430
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU361221"
FT   TRANSMEM        437..456
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU361221"
FT   TRANSMEM        484..509
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU361221"
FT   DOMAIN          569..635
FT                   /note="CBS"
FT                   /evidence="ECO:0000259|PROSITE:PS51371"
FT   DOMAIN          666..724
FT                   /note="CBS"
FT                   /evidence="ECO:0000259|PROSITE:PS51371"
SQ   SEQUENCE   729 AA;  81330 MW;  A281362B26F76707 CRC64;
     MVNAGAMSGS GNLMDFLDEP FPDVGTYEDF HTIDWLREKS RDTDRHRKIT SKSKESIWEF
     IKSLLDAWSG WVVMLLIGLL AGTLAGVIDL AVDWMTDLKE GVCLSAFWYS HEQCCWTSNE
     TTFEDRDKCP LWQKWSELLV NQSEGASAYI LNYLMYILWA LLFAFLAVSL VRVFAPYACG
     SGIPEIKTIL SGFIIRGYLG KWTLLIKTVT LVLVVSSGLS LGKEGPLVHV ACCCGNFFSS
     LFSKYSKNEG KRREVLSAAA AAGVSVAFGA PIGGVLFSLE EVSYYFPLKT LWRSFFAALV
     AAFTLRSINP FGNSRLVLFY VEYHTPWRRK TTRLGKYPVL EVIVVTAVTA IIAYPNPYTR
     RSTSELISEL FNDCGALESS QLCDYINDPN MTRPVDDIPD RPAGVGVYTA MWQLALALVF
     KIVITIFTFG MKIPSGLFIP SMAVGAMAGR MVGIGVEQLA YHHHDWIVFR NWCRPGADCV
     TPGLYAMVGA AACLGGVTRM TVSLVVIMFE LTGGLEYIVP LMAAAVTSKW VADAFGKEGI
     YEAHIHLNGY PFLDVKDEFT HRTLATDVMR PRRGEPPLSV LTQDSMTVED VETLIKETDY
     NGFPVVVSRD SERLIGFAQR RELILAIKNA RQRQEGIVSN SIMYFTEEPP ELPANSPHPL
     KLRRVLNLSP FTVTDHTPME TVVDIFRKLG LRQCLVTRSG RLLGIITKKD VLRHMAQMAN
     QDPESIMFN
//
DBGET integrated database retrieval system