ID A0A337RZ36_FELCA Unreviewed; 327 AA.
AC A0A337RZ36;
DT 10-OCT-2018, integrated into UniProtKB/TrEMBL.
DT 10-OCT-2018, sequence version 1.
DT 27-MAR-2024, entry version 26.
DE SubName: Full=Potassium channel tetramerization domain containing 12 {ECO:0000313|Ensembl:ENSFCAP00000042810.1};
GN Name=KCTD12 {ECO:0000313|Ensembl:ENSFCAP00000042810.1,
GN ECO:0000313|VGNC:VGNC:97471};
OS Felis catus (Cat) (Felis silvestris catus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Carnivora; Feliformia; Felidae; Felinae; Felis.
OX NCBI_TaxID=9685 {ECO:0000313|Ensembl:ENSFCAP00000042810.1, ECO:0000313|Proteomes:UP000011712};
RN [1] {ECO:0000313|Ensembl:ENSFCAP00000042810.1, ECO:0000313|Proteomes:UP000011712}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Abyssinian {ECO:0000313|Ensembl:ENSFCAP00000042810.1,
RC ECO:0000313|Proteomes:UP000011712};
RX PubMed=17975172; DOI=10.1101/gr.6380007;
RA Pontius J.U., Mullikin J.C., Smith D.R., Lindblad-Toh K., Gnerre S.,
RA Clamp M., Chang J., Stephens R., Neelam B., Volfovsky N., Schaffer A.A.,
RA Agarwala R., Narfstrom K., Murphy W.J., Giger U., Roca A.L., Antunes A.,
RA Menotti-Raymond M., Yuhki N., Pecon-Slattery J., Johnson W.E., Bourque G.,
RA Tesler G., O'Brien S.J.;
RT "Initial sequence and comparative analysis of the cat genome.";
RL Genome Res. 17:1675-1689(2007).
RN [2] {ECO:0000313|Ensembl:ENSFCAP00000042810.1, ECO:0000313|Proteomes:UP000011712}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Abyssinian {ECO:0000313|Ensembl:ENSFCAP00000042810.1,
RC ECO:0000313|Proteomes:UP000011712};
RA Hillier L.W., Warren W., Obrien S., Wilson R.K.;
RT "Sequence assembly of the Felis catus genome version 6.2.";
RL Submitted (SEP-2011) to the EMBL/GenBank/DDBJ databases.
RN [3] {ECO:0000313|Ensembl:ENSFCAP00000042810.1}
RP IDENTIFICATION.
RC STRAIN=breed Abyssinian {ECO:0000313|Ensembl:ENSFCAP00000042810.1};
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004651};
CC Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004651}.
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DR EMBL; AANG04001781; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR RefSeq; XP_011278726.1; XM_011280424.2.
DR AlphaFoldDB; A0A337RZ36; -.
DR STRING; 9685.ENSFCAP00000042810; -.
DR Ensembl; ENSFCAT00000007571.4; ENSFCAP00000042810.1; ENSFCAG00000007569.4.
DR GeneID; 101088711; -.
DR KEGG; fca:101088711; -.
DR CTD; 115207; -.
DR VGNC; VGNC:97471; KCTD12.
DR GeneTree; ENSGT00940000161074; -.
DR InParanoid; A0A337RZ36; -.
DR OMA; DHGMSDR; -.
DR OrthoDB; 2912088at2759; -.
DR Proteomes; UP000011712; Chromosome A1.
DR Bgee; ENSFCAG00000007569; Expressed in embryonic head and 10 other cell types or tissues.
DR GO; GO:0045211; C:postsynaptic membrane; IBA:GO_Central.
DR GO; GO:0042734; C:presynaptic membrane; IBA:GO_Central.
DR GO; GO:0043235; C:receptor complex; IBA:GO_Central.
DR GO; GO:0042802; F:identical protein binding; IEA:Ensembl.
DR GO; GO:0051260; P:protein homooligomerization; IEA:InterPro.
DR GO; GO:0008277; P:regulation of G protein-coupled receptor signaling pathway; IBA:GO_Central.
DR CDD; cd22217; H1_KCTD12; 1.
DR InterPro; IPR000210; BTB/POZ_dom.
DR InterPro; IPR011333; SKP1/BTB/POZ_sf.
DR InterPro; IPR003131; T1-type_BTB.
DR PANTHER; PTHR14499:SF29; BTB_POZ DOMAIN-CONTAINING PROTEIN KCTD12; 1.
DR PANTHER; PTHR14499; POTASSIUM CHANNEL TETRAMERIZATION DOMAIN-CONTAINING; 1.
DR Pfam; PF02214; BTB_2; 1.
DR SMART; SM00225; BTB; 1.
DR SUPFAM; SSF54695; POZ domain; 1.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000011712}.
FT DOMAIN 34..137
FT /note="BTB"
FT /evidence="ECO:0000259|SMART:SM00225"
FT REGION 1..28
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 129..150
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 166..204
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 171..185
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 327 AA; 35926 MW; 09C75EBEB1274576 CRC64;
MALADSTRGL PNGGGGGGGS GSSSSSAEPP LFPDIVELNV GGQVYVTRRC TVVSVPDSLL
WRMFTQQQPQ ELARDSKGRF FLDRDGFLFR YILDYLRDLQ LVLPDYFPER SRLQREAEYF
ELPELVRRLG APQQPGPGPP PPHSRRGVQK EGSLGDELLP LGYAEPEQQE GSSAGAPSPT
LELASRSPSG GAAGPLLTPS QSLDGSRRSG YITIGYRGSY TIGRDAQADA KFRRVARITV
CGKTSLAKEV FGDTLNESRD PDRPPERYTS RYYLKFNFLE QAFDKLSESG FHMVACSSTG
TCAFASSTDQ SEDKIWTSYT EYVFCRE
//
