ID A0A337S046_FELCA Unreviewed; 796 AA.
AC A0A337S046;
DT 10-OCT-2018, integrated into UniProtKB/TrEMBL.
DT 10-OCT-2018, sequence version 1.
DT 27-MAR-2024, entry version 26.
DE SubName: Full=Dipeptidyl peptidase like 10 {ECO:0000313|Ensembl:ENSFCAP00000043295.1};
GN Name=DPP10 {ECO:0000313|Ensembl:ENSFCAP00000043295.1,
GN ECO:0000313|VGNC:VGNC:61602};
OS Felis catus (Cat) (Felis silvestris catus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Carnivora; Feliformia; Felidae; Felinae; Felis.
OX NCBI_TaxID=9685 {ECO:0000313|Ensembl:ENSFCAP00000043295.1, ECO:0000313|Proteomes:UP000011712};
RN [1] {ECO:0000313|Ensembl:ENSFCAP00000043295.1, ECO:0000313|Proteomes:UP000011712}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Abyssinian {ECO:0000313|Ensembl:ENSFCAP00000043295.1,
RC ECO:0000313|Proteomes:UP000011712};
RX PubMed=17975172; DOI=10.1101/gr.6380007;
RA Pontius J.U., Mullikin J.C., Smith D.R., Lindblad-Toh K., Gnerre S.,
RA Clamp M., Chang J., Stephens R., Neelam B., Volfovsky N., Schaffer A.A.,
RA Agarwala R., Narfstrom K., Murphy W.J., Giger U., Roca A.L., Antunes A.,
RA Menotti-Raymond M., Yuhki N., Pecon-Slattery J., Johnson W.E., Bourque G.,
RA Tesler G., O'Brien S.J.;
RT "Initial sequence and comparative analysis of the cat genome.";
RL Genome Res. 17:1675-1689(2007).
RN [2] {ECO:0000313|Ensembl:ENSFCAP00000043295.1, ECO:0000313|Proteomes:UP000011712}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Abyssinian {ECO:0000313|Ensembl:ENSFCAP00000043295.1,
RC ECO:0000313|Proteomes:UP000011712};
RA Hillier L.W., Warren W., Obrien S., Wilson R.K.;
RT "Sequence assembly of the Felis catus genome version 6.2.";
RL Submitted (SEP-2011) to the EMBL/GenBank/DDBJ databases.
RN [3] {ECO:0000313|Ensembl:ENSFCAP00000043295.1}
RP IDENTIFICATION.
RC STRAIN=breed Abyssinian {ECO:0000313|Ensembl:ENSFCAP00000043295.1};
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004401};
CC Single-pass type II membrane protein {ECO:0000256|ARBA:ARBA00004401}.
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DR EMBL; AANG04001482; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR RefSeq; XP_019693558.1; XM_019837999.1.
DR AlphaFoldDB; A0A337S046; -.
DR Ensembl; ENSFCAT00000066215.2; ENSFCAP00000043295.1; ENSFCAG00000005743.6.
DR GeneID; 101086917; -.
DR KEGG; fca:101086917; -.
DR CTD; 57628; -.
DR VGNC; VGNC:61602; DPP10.
DR GeneTree; ENSGT00940000154657; -.
DR OrthoDB; 2876738at2759; -.
DR Proteomes; UP000011712; Chromosome C1.
DR Bgee; ENSFCAG00000005743; Expressed in brain and 9 other cell types or tissues.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0008236; F:serine-type peptidase activity; IEA:InterPro.
DR GO; GO:0006508; P:proteolysis; IEA:InterPro.
DR Gene3D; 3.40.50.1820; alpha/beta hydrolase; 1.
DR Gene3D; 2.140.10.30; Dipeptidylpeptidase IV, N-terminal domain; 1.
DR InterPro; IPR029058; AB_hydrolase.
DR InterPro; IPR001375; Peptidase_S9.
DR InterPro; IPR002469; Peptidase_S9B_N.
DR PANTHER; PTHR11731:SF21; INACTIVE DIPEPTIDYL PEPTIDASE 10; 1.
DR PANTHER; PTHR11731; PROTEASE FAMILY S9B,C DIPEPTIDYL-PEPTIDASE IV-RELATED; 1.
DR Pfam; PF00930; DPPIV_N; 1.
DR Pfam; PF00326; Peptidase_S9; 1.
DR SUPFAM; SSF53474; alpha/beta-Hydrolases; 1.
DR SUPFAM; SSF82171; DPP6 N-terminal domain-like; 1.
PE 4: Predicted;
KW Membrane {ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000011712};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 35..56
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 133..500
FT /note="Dipeptidylpeptidase IV N-terminal"
FT /evidence="ECO:0000259|Pfam:PF00930"
FT DOMAIN 581..783
FT /note="Peptidase S9 prolyl oligopeptidase catalytic"
FT /evidence="ECO:0000259|Pfam:PF00326"
FT REGION 1..27
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 796 AA; 90835 MW; 102322C79F64554A CRC64;
MNQTASVSHH IKCQPSKTVK ELGSNSPPQR NWKGIAIALL VILVVCSLIT MSVILLTPDE
LTNSSETRLS LEDLFRKDFV LHDPEARWIN DTDVVYKSEN GHVIKLNIET NATTLLLENT
TFVTFKASKH SVSPDLKYVL LAYDVKQIFH YSYTASYVIY NIHTREVWEL NPPEVEDSIL
QYAAWGVQGQ QLIYIFENNI YYQPDIKSSS LRLTSSGKEG IIFNGIADWL YEEELLHSHI
AHWWSPDGER LAFLMINDSL VPNMIIPRFT GALYPKGKQY PYPKAGQMNP TIKLYVVNLY
GPTHTLELMP PDSFKSREYY ITMVKWVSNT KTVVRWLNRP QNISILTVCE TTTGACSRKY
EMTSDTWLSK QNEEPVFSRD GSTFFMTVPV KQGGRGEFHH IAMFLVQSKS EQITVRHLTS
GNWEVIKILA YDETTQKIYF LSTESSPRGR QLYSASTEGL LNRQCISCNF MKEQCTYFGA
SFSPMNQHFL LFCKGPGIPM VSLHSTENPA KSFILESNSM LKEAILKKKI VKSEIKMLHI
DDYELPLQLS FPKDFTDRNQ YALLLIMDEE PGGQLVTDKF HIDWDSVLVD TDNVITARFD
GRGSGFQGLK ILQEIHRRLG SVEVKDQIAA VKFLLKQPYI DSKRLSIFGK GYGGYIASMI
LKSDEKLFKC GSVIAPITDL KLYASAFSER YLGMPSREES TYQASSVLHN IHGLKEENIL
IIHGTADTKV HFQHSAELIK HLIKAGVNYT MQIYPDEGHN ISEKSKYHLY STILRFFSDC
LKEEIPVLPQ EPEEDE
//
