ID A0A337S3N5_FELCA Unreviewed; 985 AA.
AC A0A337S3N5;
DT 10-OCT-2018, integrated into UniProtKB/TrEMBL.
DT 10-OCT-2018, sequence version 1.
DT 24-JAN-2024, entry version 25.
DE SubName: Full=NLR family pyrin domain containing 4 {ECO:0000313|Ensembl:ENSFCAP00000041289.1};
GN Name=NLRP4 {ECO:0000313|Ensembl:ENSFCAP00000041289.1};
OS Felis catus (Cat) (Felis silvestris catus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Carnivora; Feliformia; Felidae; Felinae; Felis.
OX NCBI_TaxID=9685 {ECO:0000313|Ensembl:ENSFCAP00000041289.1, ECO:0000313|Proteomes:UP000011712};
RN [1] {ECO:0000313|Ensembl:ENSFCAP00000041289.1, ECO:0000313|Proteomes:UP000011712}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Abyssinian {ECO:0000313|Ensembl:ENSFCAP00000041289.1,
RC ECO:0000313|Proteomes:UP000011712};
RX PubMed=17975172; DOI=10.1101/gr.6380007;
RA Pontius J.U., Mullikin J.C., Smith D.R., Lindblad-Toh K., Gnerre S.,
RA Clamp M., Chang J., Stephens R., Neelam B., Volfovsky N., Schaffer A.A.,
RA Agarwala R., Narfstrom K., Murphy W.J., Giger U., Roca A.L., Antunes A.,
RA Menotti-Raymond M., Yuhki N., Pecon-Slattery J., Johnson W.E., Bourque G.,
RA Tesler G., O'Brien S.J.;
RT "Initial sequence and comparative analysis of the cat genome.";
RL Genome Res. 17:1675-1689(2007).
RN [2] {ECO:0000313|Ensembl:ENSFCAP00000041289.1, ECO:0000313|Proteomes:UP000011712}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Abyssinian {ECO:0000313|Ensembl:ENSFCAP00000041289.1,
RC ECO:0000313|Proteomes:UP000011712};
RA Hillier L.W., Warren W., Obrien S., Wilson R.K.;
RT "Sequence assembly of the Felis catus genome version 6.2.";
RL Submitted (SEP-2011) to the EMBL/GenBank/DDBJ databases.
RN [3] {ECO:0000313|Ensembl:ENSFCAP00000041289.1}
RP IDENTIFICATION.
RC STRAIN=breed Abyssinian {ECO:0000313|Ensembl:ENSFCAP00000041289.1};
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
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DR EMBL; AANG04003316; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR RefSeq; XP_011287849.1; XM_011289547.2.
DR AlphaFoldDB; A0A337S3N5; -.
DR STRING; 9685.ENSFCAP00000041289; -.
DR PaxDb; 9685-ENSFCAP00000023106; -.
DR Ensembl; ENSFCAT00000060100.2; ENSFCAP00000041289.1; ENSFCAG00000046106.2.
DR GeneID; 101087284; -.
DR KEGG; fca:101087284; -.
DR GeneTree; ENSGT00940000162284; -.
DR InParanoid; A0A337S3N5; -.
DR OMA; THPDCRV; -.
DR OrthoDB; 55870at2759; -.
DR Proteomes; UP000011712; Chromosome E2.
DR Bgee; ENSFCAG00000046106; Expressed in adult mammalian kidney.
DR GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR GO; GO:0060090; F:molecular adaptor activity; IEA:Ensembl.
DR GO; GO:0045824; P:negative regulation of innate immune response; IEA:Ensembl.
DR GO; GO:0050727; P:regulation of inflammatory response; IBA:GO_Central.
DR CDD; cd08320; Pyrin_NALPs; 1.
DR Gene3D; 1.10.533.10; Death Domain, Fas; 1.
DR Gene3D; 3.80.10.10; Ribonuclease Inhibitor; 2.
DR InterPro; IPR004020; DAPIN.
DR InterPro; IPR011029; DEATH-like_dom_sf.
DR InterPro; IPR032675; LRR_dom_sf.
DR InterPro; IPR007111; NACHT_NTPase.
DR InterPro; IPR041267; NLRP_HD2.
DR InterPro; IPR041075; NOD2_WH.
DR InterPro; IPR027417; P-loop_NTPase.
DR PANTHER; PTHR45690; NACHT, LRR AND PYD DOMAINS-CONTAINING PROTEIN 12; 1.
DR PANTHER; PTHR45690:SF6; NACHT, LRR AND PYD DOMAINS-CONTAINING PROTEIN 4; 1.
DR Pfam; PF05729; NACHT; 1.
DR Pfam; PF17776; NLRC4_HD2; 1.
DR Pfam; PF17779; NOD2_WH; 1.
DR Pfam; PF02758; PYRIN; 1.
DR SMART; SM00368; LRR_RI; 9.
DR SMART; SM01289; PYRIN; 1.
DR SUPFAM; SSF47986; DEATH domain; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR SUPFAM; SSF52047; RNI-like; 1.
DR PROSITE; PS50824; DAPIN; 1.
DR PROSITE; PS50837; NACHT; 1.
PE 4: Predicted;
KW Leucine-rich repeat {ECO:0000256|ARBA:ARBA00022614};
KW Reference proteome {ECO:0000313|Proteomes:UP000011712}.
FT DOMAIN 1..94
FT /note="Pyrin"
FT /evidence="ECO:0000259|PROSITE:PS50824"
FT DOMAIN 149..281
FT /note="NACHT"
FT /evidence="ECO:0000259|PROSITE:PS50837"
SQ SEQUENCE 985 AA; 112999 MW; 376407E077C624D2 CRC64;
MASSFFSDFG LMWYLEELKK DEFRKFKELL KQESLKLGLK IIPWTEVKKA TREDLANLLM
RHYKEQQAWN VTFSVFNKIN RKDLCEKAKK EITGHTKLYQ MHVKEKFNNM WLRESIPRIQ
DHLHPELTQR ERECLELFFA PKETGKQTRT VLLKGIQGIG KTTFLIRLML AWVEGNLYQE
RFSYVFYLCC REMKQLTETS LAALLSRGWS DSSTPFVEIL SQPERLLFLI DSFEELKCSL
SEPESDLCSD CMEQVPVQVL LSSLLRKKLL PESSLLITAT PVYPQEVEDR LECPEIRTLL
GFSDSDKKIY FCSMFQDRNR AMEAFSFMRE NEHLFIMCQI PILCWIVSTC LKQDMEKGKD
LALTCRRTTS LYSSFIFNLF TPKGASCPDE QSQGQLKGLC SLAAEGMWTN MFLFSEGDLR
RNGLVDSDIS TLLDIKALQK CKEEENSYMF LHVSVQEFCA AMFYFLKSHM DHPNPAIGCR
KAVLFTYLKK EKVHWISLGC FIFGLLNEKE QQKLDTVFGF HLSQEIQQEC HQYLQRIGEN
EHLQKQTDFL ALCYCLFEMQ NEGFVQWAMD FFQDVHFTIT DHVDLRVSAY CLKYCSSLQK
LCFSIQNVFQ VGNADSSVSS YNILCWHDIC SVLTTNEHLR ELQMSHSILS ESTYVTLCNQ
LRHPSCHLQK LQMNNVTFAG DSWLFFEVLT HSPDLKYLNL NGTTLSRNDV KLLCNALNNP
MCNVEELLLA NCHLSANDCE DFTCVLNSSK KLKLLNVSYN YLDQGVPLLC EALQRPDCGL
EGLILGYCYL TEHSWKYLYN VLLYNKSLTH LDLSANVLKY ENLKLLCEAL KQPGCHLWSL
CLVKCSITAD GCRDLASVLT GNQNLRSLQI SYNDIEDAGV KLLCQGLAHP SCHLEILGLA
TCKLTSACCE DLSSALTSSK TLQSLNLQGN ALDHTGVAVL CEALRHPACT LQILGLQKTE
FDEETQRLLT VAEEENPSLT VIGDW
//
