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Database: UniProt
Entry: A0A337S4Q9_FELCA
LinkDB: A0A337S4Q9_FELCA
Original site: A0A337S4Q9_FELCA 
ID   A0A337S4Q9_FELCA        Unreviewed;       857 AA.
AC   A0A337S4Q9;
DT   10-OCT-2018, integrated into UniProtKB/TrEMBL.
DT   10-OCT-2018, sequence version 1.
DT   24-JAN-2024, entry version 27.
DE   RecName: Full=G-protein coupled receptor family C group 6 member A {ECO:0000256|ARBA:ARBA00039774};
GN   Name=GPRC6A {ECO:0000313|Ensembl:ENSFCAP00000041750.1,
GN   ECO:0000313|VGNC:VGNC:102433};
OS   Felis catus (Cat) (Felis silvestris catus).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Carnivora; Feliformia; Felidae; Felinae; Felis.
OX   NCBI_TaxID=9685 {ECO:0000313|Ensembl:ENSFCAP00000041750.1, ECO:0000313|Proteomes:UP000011712};
RN   [1] {ECO:0000313|Ensembl:ENSFCAP00000041750.1, ECO:0000313|Proteomes:UP000011712}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Abyssinian {ECO:0000313|Ensembl:ENSFCAP00000041750.1,
RC   ECO:0000313|Proteomes:UP000011712};
RX   PubMed=17975172; DOI=10.1101/gr.6380007;
RA   Pontius J.U., Mullikin J.C., Smith D.R., Lindblad-Toh K., Gnerre S.,
RA   Clamp M., Chang J., Stephens R., Neelam B., Volfovsky N., Schaffer A.A.,
RA   Agarwala R., Narfstrom K., Murphy W.J., Giger U., Roca A.L., Antunes A.,
RA   Menotti-Raymond M., Yuhki N., Pecon-Slattery J., Johnson W.E., Bourque G.,
RA   Tesler G., O'Brien S.J.;
RT   "Initial sequence and comparative analysis of the cat genome.";
RL   Genome Res. 17:1675-1689(2007).
RN   [2] {ECO:0000313|Ensembl:ENSFCAP00000041750.1, ECO:0000313|Proteomes:UP000011712}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Abyssinian {ECO:0000313|Ensembl:ENSFCAP00000041750.1,
RC   ECO:0000313|Proteomes:UP000011712};
RA   Hillier L.W., Warren W., Obrien S., Wilson R.K.;
RT   "Sequence assembly of the Felis catus genome version 6.2.";
RL   Submitted (SEP-2011) to the EMBL/GenBank/DDBJ databases.
RN   [3] {ECO:0000313|Ensembl:ENSFCAP00000041750.1}
RP   IDENTIFICATION.
RC   STRAIN=breed Abyssinian {ECO:0000313|Ensembl:ENSFCAP00000041750.1};
RG   Ensembl;
RL   Submitted (SEP-2023) to UniProtKB.
CC   -!- SUBUNIT: Homodimer; disulfide-linked. {ECO:0000256|ARBA:ARBA00011748}.
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004651};
CC       Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004651}. Membrane
CC       {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC       {ECO:0000256|ARBA:ARBA00004141}.
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DR   EMBL; AANG04000169; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   AlphaFoldDB; A0A337S4Q9; -.
DR   Ensembl; ENSFCAT00000062831.2; ENSFCAP00000041750.1; ENSFCAG00000044183.2.
DR   VGNC; VGNC:102433; GPRC6A.
DR   GeneTree; ENSGT00940000158416; -.
DR   Proteomes; UP000011712; Chromosome B2.
DR   Bgee; ENSFCAG00000044183; Expressed in adult mammalian kidney and 1 other cell type or tissue.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0004930; F:G protein-coupled receptor activity; IEA:UniProtKB-KW.
DR   CDD; cd15281; 7tmC_GPRC6A; 1.
DR   Gene3D; 3.40.50.2300; -; 2.
DR   Gene3D; 2.10.50.30; GPCR, family 3, nine cysteines domain; 1.
DR   InterPro; IPR001828; ANF_lig-bd_rcpt.
DR   InterPro; IPR000337; GPCR_3.
DR   InterPro; IPR011500; GPCR_3_9-Cys_dom.
DR   InterPro; IPR038550; GPCR_3_9-Cys_sf.
DR   InterPro; IPR017978; GPCR_3_C.
DR   InterPro; IPR000068; GPCR_3_Ca_sens_rcpt-rel.
DR   InterPro; IPR017979; GPCR_3_CS.
DR   InterPro; IPR028082; Peripla_BP_I.
DR   PANTHER; PTHR24061; CALCIUM-SENSING RECEPTOR-RELATED; 1.
DR   PANTHER; PTHR24061:SF5; G-PROTEIN COUPLED RECEPTOR FAMILY C GROUP 6 MEMBER A; 1.
DR   Pfam; PF00003; 7tm_3; 1.
DR   Pfam; PF01094; ANF_receptor; 1.
DR   Pfam; PF07562; NCD3G; 1.
DR   PRINTS; PR00248; GPCRMGR.
DR   SUPFAM; SSF53822; Periplasmic binding protein-like I; 1.
DR   PROSITE; PS00980; G_PROTEIN_RECEP_F3_2; 1.
DR   PROSITE; PS50259; G_PROTEIN_RECEP_F3_4; 1.
PE   4: Predicted;
KW   Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW   G-protein coupled receptor {ECO:0000256|ARBA:ARBA00023040};
KW   Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW   Receptor {ECO:0000256|ARBA:ARBA00023170};
KW   Reference proteome {ECO:0000313|Proteomes:UP000011712};
KW   Signal {ECO:0000256|ARBA:ARBA00022729, ECO:0000256|SAM:SignalP};
KW   Transducer {ECO:0000256|ARBA:ARBA00023224};
KW   Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW   ECO:0000256|SAM:Phobius}.
FT   SIGNAL          1..18
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT   CHAIN           19..857
FT                   /note="G-protein coupled receptor family C group 6 member
FT                   A"
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT                   /id="PRO_5016371736"
FT   TRANSMEM        522..545
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        557..581
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        593..615
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        636..658
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        678..700
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        712..734
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        740..762
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   DOMAIN          522..778
FT                   /note="G-protein coupled receptors family 3 profile"
FT                   /evidence="ECO:0000259|PROSITE:PS50259"
FT   REGION          838..857
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        839..857
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   857 AA;  96313 MW;  39A8B0D2F6506469 CRC64;
     MALLITLITC FVIPLATSQT CQTPDDFVAA TSPGHVIIGG LFAIHEKMLS SEDYPRRPEI
     QKCVGFEISI FLQTLAMIHS IEMINNSTLL SGIKLGYEIY DTCTEVTVAM AAALRFLSKF
     NSSREIMEFK CDYSSYMPRV KAVIGAGYSE ITMAVSRMLN LQLMPQVSYE STAEILSDKI
     RFPSFLRTVP SDFYQTKAMA HLIEKSGWNW IGIIATDDDY GRMALNTFAV QTTANNVCIA
     FKEVLPAFLS DNTIEVRINE TLEKIIAEAQ VNVIVVFLRQ FHVFNLFSKA LERNINKIWI
     ASDNWSTATK ITTIPNVKRI GKVVGFTFRR GNMSSFHSFL QNLHIFPSDN NKVLNEYATL
     LSACAYVKDS DLSQCISNHS QGTLAYKVNK DIERNFSLRN DFLWNYTEPG LVHSIQLAVL
     ALGYAIRDLC QARDCQNPNA FQPWEQIQSK CSKECSPGQM KKTTRSQHIC CYECVNCPEN
     HYSNQTDMDH CLLCNNETQW APVKSTACFE KEVEYLSWND SLAILLLALS LLGIMFVLAI
     GIIFTRNLNT PVVKSSGGLL VCYVILLCHF LNFASTGFFI GEPQDFTCKT RQTFFGVSFT
     LCISCILVKS LKILLAFSFD PKLQNFLKCL YKPIPIIFIC TGIQVAICTV WLIFAAPAVE
     ENVSLPRVII LECEEGSILA FGIMLGYIAI LAFICFIFAF KGRKLPENYN EAKFITFGML
     VYFIAWITFV PVYATTFGKY LPAVEIIIIL ISNYGILCCT FFPKCYVILY KQETNTKSAF
     LKMIYSYSSH SASSLAMSHV SLDSSSSNIT ATNPSSGGRP AAWQESRDIR AQAFAHTRRE
     NAASMSKTWP RKRISSI
//
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