ID A0A337S4S7_FELCA Unreviewed; 1366 AA.
AC A0A337S4S7;
DT 10-OCT-2018, integrated into UniProtKB/TrEMBL.
DT 10-OCT-2018, sequence version 1.
DT 24-JAN-2024, entry version 19.
DE SubName: Full=Patched 1 {ECO:0000313|Ensembl:ENSFCAP00000045263.1};
GN Name=PTCH1 {ECO:0000313|Ensembl:ENSFCAP00000045263.1,
GN ECO:0000313|VGNC:VGNC:69135};
OS Felis catus (Cat) (Felis silvestris catus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Carnivora; Feliformia; Felidae; Felinae; Felis.
OX NCBI_TaxID=9685 {ECO:0000313|Ensembl:ENSFCAP00000045263.1, ECO:0000313|Proteomes:UP000011712};
RN [1] {ECO:0000313|Ensembl:ENSFCAP00000045263.1, ECO:0000313|Proteomes:UP000011712}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Abyssinian {ECO:0000313|Ensembl:ENSFCAP00000045263.1,
RC ECO:0000313|Proteomes:UP000011712};
RX PubMed=17975172; DOI=10.1101/gr.6380007;
RA Pontius J.U., Mullikin J.C., Smith D.R., Lindblad-Toh K., Gnerre S.,
RA Clamp M., Chang J., Stephens R., Neelam B., Volfovsky N., Schaffer A.A.,
RA Agarwala R., Narfstrom K., Murphy W.J., Giger U., Roca A.L., Antunes A.,
RA Menotti-Raymond M., Yuhki N., Pecon-Slattery J., Johnson W.E., Bourque G.,
RA Tesler G., O'Brien S.J.;
RT "Initial sequence and comparative analysis of the cat genome.";
RL Genome Res. 17:1675-1689(2007).
RN [2] {ECO:0000313|Ensembl:ENSFCAP00000045263.1, ECO:0000313|Proteomes:UP000011712}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Abyssinian {ECO:0000313|Ensembl:ENSFCAP00000045263.1,
RC ECO:0000313|Proteomes:UP000011712};
RA Hillier L.W., Warren W., Obrien S., Wilson R.K.;
RT "Sequence assembly of the Felis catus genome version 6.2.";
RL Submitted (SEP-2011) to the EMBL/GenBank/DDBJ databases.
RN [3] {ECO:0000313|Ensembl:ENSFCAP00000045263.1}
RP IDENTIFICATION.
RC STRAIN=breed Abyssinian {ECO:0000313|Ensembl:ENSFCAP00000045263.1};
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the patched family.
CC {ECO:0000256|ARBA:ARBA00005585}.
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DR EMBL; AANG04000264; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR Ensembl; ENSFCAT00000063282.2; ENSFCAP00000045263.1; ENSFCAG00000011205.6.
DR VGNC; VGNC:69135; PTCH1.
DR GeneTree; ENSGT00940000159011; -.
DR Proteomes; UP000011712; Chromosome D4.
DR Bgee; ENSFCAG00000011205; Expressed in embryonic head and 9 other cell types or tissues.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0008158; F:hedgehog receptor activity; IEA:InterPro.
DR Gene3D; 1.20.1640.10; Multidrug efflux transporter AcrB transmembrane domain; 1.
DR InterPro; IPR003392; Ptc/Disp.
DR InterPro; IPR000731; SSD.
DR InterPro; IPR004766; TM_rcpt_patched.
DR NCBIfam; TIGR00918; 2A060602; 1.
DR PANTHER; PTHR46022; PROTEIN PATCHED; 1.
DR PANTHER; PTHR46022:SF5; PROTEIN PATCHED HOMOLOG 1; 1.
DR Pfam; PF02460; Patched; 1.
DR Pfam; PF12349; Sterol-sensing; 1.
DR SUPFAM; SSF82866; Multidrug efflux transporter AcrB transmembrane domain; 2.
DR PROSITE; PS50156; SSD; 1.
PE 3: Inferred from homology;
KW Membrane {ECO:0000256|SAM:Phobius};
KW Receptor {ECO:0000256|ARBA:ARBA00023170};
KW Reference proteome {ECO:0000313|Proteomes:UP000011712};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 460..481
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 487..510
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 665..682
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 941..962
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 968..990
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 997..1023
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1035..1055
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1067..1092
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 449..512
FT /note="SSD"
FT /evidence="ECO:0000259|PROSITE:PS50156"
FT REGION 1..36
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1103..1147
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1187..1272
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1107..1121
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1127..1147
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1216..1240
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1366 AA; 152239 MW; 0B1B2BBC17DAF723 CRC64;
MASAGNAAEP QDRGGGGSCS GAPGRPAGGG RRRRTGGLRR NAALDRDYLH RPSYCDAAFA
LEQISKGKAT GRKAPLWLRA KFQRLLFKLG CYIQKNCGKF LVVGLLIFGA FAVGLKAANL
ETNVEELWVE VGGRVSRELN YTRQKIGEEA MFNPQLMIQT PKEEGANVLT TEALRQHLDS
ALQASRVHVY MYNRQWKLEH LCYKSGELIT ETGYMDQIIE YLYPCLIITP LDCFWEGAKL
QSGTAYLLGK PPLQWTNFDP LEFLEELKKI NYQVDSWEEM LNKAQVGHGY MDRPCLNPAD
PDCPATAPNK NATKPLDVAL VLNGGCHGLS RKYMHWQEEL IVGGTVKNST GKLVSAHALQ
TMFQLMTPKQ MYEHFKGYEY VSHINWNEDK AAAILEAWQR TYVEVVHQSV APNSTQKVLS
FTTTTLDDIL KSFSDVSVIR VASGYLLMDR TGECLKRTGA SVALTSISNV TAFFMAALIP
IPALRAFSLQ AAVVVVFNFA MVLLIFPAIL SMDLYRREDR RLDIFCCFTS PCVSRVIQVE
PQAYTETHDN TRYSPPPPYS SHSFTHETQI TMQSTVQLRT EYDPHTHVYY TTAEPRSEIS
VQPVTMTQDT LSCQSPESTS STRDLLSQFS DSSLHCLEPP CTKWTLSSFA EKHYAPFLLK
PKAKVVVIFL FLGLLGVSLY GTTRVRDGLD LTDIVPRETR EYDFIAAQFK YFSFYNMYIV
TQKADYPNIQ HLLYDLHKSF SSVKYVMLEE NKQLPKMWLH YFRDWLQGLQ DAFDSDWETG
KIMPNNYKNG SDDGVLAYKL LVQTGSRDKP IDISQLTKRR LVDADGIINP SAFYIYLTAW
VSNDPVAYAA SQANIRPHRP EWVHDKADYM PETRLRIPAA EPIEYAQFPF YLNGLRDTSD
FVEAIEKVRT ICNNYTSLGL SSYPNGYPFL FWEQYIGLRH WLLLSISVVL ACTFLVCAVF
LLNPWTAGII VTVLALMTVE LFGMMGLIGI KLSAVPVVIL IASVGIGVEF TVHVALAFLT
AIGDKNRRAV LALEHMFAPV LDGAVSTLLG VLMLAGSEFD FIVRYFFAVL AILTILGVLN
GLVLLPVLLS FFGPYPEVSP ANGLNRLPTP SPEPPPSVVR FSVPPGHANN GSDSSDSEYS
SQTTVSGISE ELRHYEAQQG TRGPAHQVIV EATENPVFAR STVVHPEARH HPPSNPRQHP
HLDSESLPPG RPGQQPRREP PREGSRPPPY RPRRDAFEIS TDGHSGPSNR DRAGPRGARS
NNPRHPAFTA MGSSAPSYCQ PITTVTASAS VTVAVHPPPA PGPGSGRNPR GGLCPGYGDY
SETDHGLFED PHVPFNVRCE RRDSKVEVIE LQDVECEERP RGRSSN
//
