ID A0A337S5A1_FELCA Unreviewed; 1038 AA.
AC A0A337S5A1;
DT 10-OCT-2018, integrated into UniProtKB/TrEMBL.
DT 10-OCT-2018, sequence version 1.
DT 27-MAR-2024, entry version 24.
DE SubName: Full=FERM domain containing 4A {ECO:0000313|Ensembl:ENSFCAP00000041246.1};
GN Name=FRMD4A {ECO:0000313|Ensembl:ENSFCAP00000041246.1,
GN ECO:0000313|VGNC:VGNC:62360};
OS Felis catus (Cat) (Felis silvestris catus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Carnivora; Feliformia; Felidae; Felinae; Felis.
OX NCBI_TaxID=9685 {ECO:0000313|Ensembl:ENSFCAP00000041246.1, ECO:0000313|Proteomes:UP000011712};
RN [1] {ECO:0000313|Ensembl:ENSFCAP00000041246.1, ECO:0000313|Proteomes:UP000011712}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Abyssinian {ECO:0000313|Ensembl:ENSFCAP00000041246.1,
RC ECO:0000313|Proteomes:UP000011712};
RX PubMed=17975172; DOI=10.1101/gr.6380007;
RA Pontius J.U., Mullikin J.C., Smith D.R., Lindblad-Toh K., Gnerre S.,
RA Clamp M., Chang J., Stephens R., Neelam B., Volfovsky N., Schaffer A.A.,
RA Agarwala R., Narfstrom K., Murphy W.J., Giger U., Roca A.L., Antunes A.,
RA Menotti-Raymond M., Yuhki N., Pecon-Slattery J., Johnson W.E., Bourque G.,
RA Tesler G., O'Brien S.J.;
RT "Initial sequence and comparative analysis of the cat genome.";
RL Genome Res. 17:1675-1689(2007).
RN [2] {ECO:0000313|Ensembl:ENSFCAP00000041246.1, ECO:0000313|Proteomes:UP000011712}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Abyssinian {ECO:0000313|Ensembl:ENSFCAP00000041246.1,
RC ECO:0000313|Proteomes:UP000011712};
RA Hillier L.W., Warren W., Obrien S., Wilson R.K.;
RT "Sequence assembly of the Felis catus genome version 6.2.";
RL Submitted (SEP-2011) to the EMBL/GenBank/DDBJ databases.
RN [3] {ECO:0000313|Ensembl:ENSFCAP00000041246.1}
RP IDENTIFICATION.
RC STRAIN=breed Abyssinian {ECO:0000313|Ensembl:ENSFCAP00000041246.1};
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
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DR EMBL; AANG04002256; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; A0A337S5A1; -.
DR Ensembl; ENSFCAT00000057376.2; ENSFCAP00000041246.1; ENSFCAG00000004437.6.
DR VGNC; VGNC:62360; FRMD4A.
DR GeneTree; ENSGT01020000230354; -.
DR Proteomes; UP000011712; Chromosome B4.
DR Bgee; ENSFCAG00000004437; Expressed in embryonic head and 9 other cell types or tissues.
DR GO; GO:0005856; C:cytoskeleton; IEA:InterPro.
DR GO; GO:0090162; P:establishment of epithelial cell polarity; IEA:InterPro.
DR CDD; cd14473; FERM_B-lobe; 1.
DR CDD; cd13191; FERM_C_FRMD4A_FRMD4B; 1.
DR CDD; cd17200; FERM_F1_FRMD4B; 1.
DR Gene3D; 1.20.80.10; -; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR InterPro; IPR019749; Band_41_domain.
DR InterPro; IPR021774; CUPID.
DR InterPro; IPR014352; FERM/acyl-CoA-bd_prot_sf.
DR InterPro; IPR035963; FERM_2.
DR InterPro; IPR019748; FERM_central.
DR InterPro; IPR019747; FERM_CS.
DR InterPro; IPR000299; FERM_domain.
DR InterPro; IPR018979; FERM_N.
DR InterPro; IPR018980; FERM_PH-like_C.
DR InterPro; IPR047176; FRMD4A/B.
DR InterPro; IPR041785; FRMD4A/B_FERM_C.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR029071; Ubiquitin-like_domsf.
DR PANTHER; PTHR46079; FERM DOMAIN-CONTAINING PROTEIN 4; 1.
DR PANTHER; PTHR46079:SF3; FERM DOMAIN-CONTAINING PROTEIN 4A; 1.
DR Pfam; PF11819; CUPID; 1.
DR Pfam; PF09380; FERM_C; 1.
DR Pfam; PF00373; FERM_M; 1.
DR Pfam; PF09379; FERM_N; 1.
DR PRINTS; PR00935; BAND41.
DR SMART; SM00295; B41; 1.
DR SMART; SM01196; FERM_C; 1.
DR SUPFAM; SSF50729; PH domain-like; 1.
DR SUPFAM; SSF47031; Second domain of FERM; 1.
DR SUPFAM; SSF54236; Ubiquitin-like; 1.
DR PROSITE; PS00660; FERM_1; 1.
DR PROSITE; PS00661; FERM_2; 1.
DR PROSITE; PS50057; FERM_3; 1.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000011712}.
FT DOMAIN 27..329
FT /note="FERM"
FT /evidence="ECO:0000259|PROSITE:PS50057"
FT REGION 373..393
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 561..687
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 720..763
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 779..812
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 882..921
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 935..967
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 979..1038
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 576..591
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 641..683
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 947..967
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 982..1038
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1038 AA; 115871 MW; 833DE4E85A546E06 CRC64;
MTLAAKLEDF EVTLEHLLMD VFMTEGRRCQ VHLLDDRKLE LLVQPKLLAK ELLDLVASHF
NLKEKEYFGI AFTDETGHLN WLQLDRRVLE HDFPKKSGPV VLYFCVRFYI ESISYLKDNA
TIELFFLNAK SCIYKELIDV DSEVVFELAS YILQEAKGDF SSNEVVRSDL KKLPALPTQA
LKEHPSLAYC EDRVIEHYKK LNGQTRGQAI VNYMSIVESL PTYGVHYYAV KDKQGIPWWL
GLSYKGIFQY DYHDKVKPRK IFQWRQLENL YFREKKFSVE VHDPRRASVT RRTFGHSGIA
VHTWYACPAL IKSIWAMAIS QHQFYLDRKQ SKSKIHAARS LSEIAIDLTE TGTLKTSKLA
NMGSKGKIIS GSSGSLLSSG SQESDSSQSA KKDMLAALKS RQEALEETLR QRLEELKKLC
LREAELTGKL PIEYPLDPGE EPPIVRRRIG TAFKLDEQKI LPKGEEAELE RLEREFAIQS
QITEAARRLA SDPNVSKKLK KQRKTSYLNA LRKLQEIENA INENRIKSGK KPTQRASLII
ADGNIASEDS SLSDALVLED EDSQVTSTLS PLQSPHKGLP PRPPSHNRPP PPQSLEGLRQ
MHYHGSDYDK SPIKPKMWSE SSLDEPYEKV KKRSSHGHSS SHKRFPSTGS CAEAGGGSSS
LQNSPIRSLP HWNSQSSMPS TPDLRVRSPH YVHSTRSVDL SPTRLHSLAL HFRHRSSSLE
SQGKLLGSEN DTGSPDFYTP RTRSSNGSDP MDDCSSCTSH SSSEHYYPAQ MNANYSTLAE
DSPSKARARQ RQRQRAAGAL GAANSGSMPN LAARGGGAHG VYLHSQSQPS SQYRIKEYPL
YIEGGATPVV VRSLESDQEG HYSVKAQFKT SNSYTAGGLF RESWRGGDEG DAGRLTPSRS
QILRTPSLGR EGAHDKGAGR AAVSDELRLW YQRSTASHKE HSRLSHTSST SSDSGSQYST
SSQSTFVAHS RVTRMPQMCK ATSAALPQSQ RSSTPSSEIG VTPPSSPHHI LTWQTGEATE
NSPIMDGSES PTHQSTDD
//
