ID A0A337S5P9_FELCA Unreviewed; 602 AA.
AC A0A337S5P9;
DT 10-OCT-2018, integrated into UniProtKB/TrEMBL.
DT 11-DEC-2019, sequence version 2.
DT 24-JAN-2024, entry version 21.
DE SubName: Full=Chordin like 1 {ECO:0000313|Ensembl:ENSFCAP00000042126.2};
GN Name=CHRDL1 {ECO:0000313|Ensembl:ENSFCAP00000042126.2,
GN ECO:0000313|VGNC:VGNC:60871};
OS Felis catus (Cat) (Felis silvestris catus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Carnivora; Feliformia; Felidae; Felinae; Felis.
OX NCBI_TaxID=9685 {ECO:0000313|Ensembl:ENSFCAP00000042126.2, ECO:0000313|Proteomes:UP000011712};
RN [1] {ECO:0000313|Ensembl:ENSFCAP00000042126.2, ECO:0000313|Proteomes:UP000011712}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Abyssinian {ECO:0000313|Ensembl:ENSFCAP00000042126.2,
RC ECO:0000313|Proteomes:UP000011712};
RX PubMed=17975172; DOI=10.1101/gr.6380007;
RA Pontius J.U., Mullikin J.C., Smith D.R., Lindblad-Toh K., Gnerre S.,
RA Clamp M., Chang J., Stephens R., Neelam B., Volfovsky N., Schaffer A.A.,
RA Agarwala R., Narfstrom K., Murphy W.J., Giger U., Roca A.L., Antunes A.,
RA Menotti-Raymond M., Yuhki N., Pecon-Slattery J., Johnson W.E., Bourque G.,
RA Tesler G., O'Brien S.J.;
RT "Initial sequence and comparative analysis of the cat genome.";
RL Genome Res. 17:1675-1689(2007).
RN [2] {ECO:0000313|Ensembl:ENSFCAP00000042126.2, ECO:0000313|Proteomes:UP000011712}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Abyssinian {ECO:0000313|Ensembl:ENSFCAP00000042126.2,
RC ECO:0000313|Proteomes:UP000011712};
RA Hillier L.W., Warren W., Obrien S., Wilson R.K.;
RT "Sequence assembly of the Felis catus genome version 6.2.";
RL Submitted (SEP-2011) to the EMBL/GenBank/DDBJ databases.
RN [3] {ECO:0000313|Ensembl:ENSFCAP00000042126.2}
RP IDENTIFICATION.
RC STRAIN=breed Abyssinian {ECO:0000313|Ensembl:ENSFCAP00000042126.2};
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|ARBA:ARBA00004613}.
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DR EMBL; AANG04001034; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; A0A337S5P9; -.
DR STRING; 9685.ENSFCAP00000042126; -.
DR Ensembl; ENSFCAT00000051331.2; ENSFCAP00000042126.2; ENSFCAG00000008546.6.
DR VGNC; VGNC:60871; CHRDL1.
DR GeneTree; ENSGT00940000160983; -.
DR InParanoid; A0A337S5P9; -.
DR Proteomes; UP000011712; Chromosome X.
DR Bgee; ENSFCAG00000008546; Expressed in eyeball of camera-type eye and 10 other cell types or tissues.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR GO; GO:0005886; C:plasma membrane; IEA:GOC.
DR GO; GO:0045202; C:synapse; IEA:GOC.
DR GO; GO:0036122; F:BMP binding; IBA:GO_Central.
DR GO; GO:0050431; F:transforming growth factor beta binding; IEA:Ensembl.
DR GO; GO:0097113; P:AMPA glutamate receptor clustering; IEA:Ensembl.
DR GO; GO:0030509; P:BMP signaling pathway; IEA:Ensembl.
DR GO; GO:0030154; P:cell differentiation; IBA:GO_Central.
DR GO; GO:0000578; P:embryonic axis specification; IEA:Ensembl.
DR GO; GO:0098976; P:excitatory chemical synaptic transmission; IEA:Ensembl.
DR GO; GO:0001654; P:eye development; IEA:Ensembl.
DR GO; GO:0030514; P:negative regulation of BMP signaling pathway; IBA:GO_Central.
DR GO; GO:0048167; P:regulation of synaptic plasticity; IEA:Ensembl.
DR GO; GO:0060074; P:synapse maturation; IEA:Ensembl.
DR Gene3D; 2.10.70.10; Complement Module, domain 1; 2.
DR InterPro; IPR045717; CHRDL1/2.
DR InterPro; IPR045716; CHRDL_1/2_C.
DR InterPro; IPR001007; VWF_dom.
DR PANTHER; PTHR46303:SF2; CHORDIN-LIKE PROTEIN 1; 1.
DR PANTHER; PTHR46303; VWFC DOMAIN-CONTAINING PROTEIN; 1.
DR Pfam; PF19548; CHRDL_1_2_C; 1.
DR Pfam; PF00093; VWC; 2.
DR SMART; SM00214; VWC; 2.
DR SUPFAM; SSF57603; FnI-like domain; 2.
DR PROSITE; PS01208; VWFC_1; 2.
DR PROSITE; PS50184; VWFC_2; 2.
PE 4: Predicted;
KW Developmental protein {ECO:0000256|ARBA:ARBA00022473};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Reference proteome {ECO:0000313|Proteomes:UP000011712};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Secreted {ECO:0000256|ARBA:ARBA00022525}.
FT DOMAIN 256..322
FT /note="VWFC"
FT /evidence="ECO:0000259|PROSITE:PS50184"
FT DOMAIN 401..466
FT /note="VWFC"
FT /evidence="ECO:0000259|PROSITE:PS50184"
FT REGION 1..45
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 344..364
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 602 AA; 68112 MW; FC49EA5B29FA5D24 CRC64;
MFFLPPTFES PLPPRAHSSS RHNLRAPDLG GAPRGARSAC TRGRRSRPVA RSLNIPGPDS
FEWPLAVTKM RKKWKVGGTK CIFSLLLFFL FLEGSKTEQV KHSETYCVFQ DKKYRVGERW
HPYLEPYGLV YCVNCICSEL EPERLETPQS QARRSFCPQL AGGFENESSG DPSFRKICQP
AIHQPSRRAS DETREENADF IQLLGNASFA VWNGNVLCSR VRCPSLHCVS PVHIPHLCCP
RCPDSLPPAN NKVTSKSCEY NGTTYQHGEL FMAEGLFQNR QPNQCTQCSC SEGNVYCGLK
TCPKLTCAFP VSVPDSCCRV CRGDGELSWE HSDGDIFRQP ANREARHSYH RSHYDPPPSR
QAGGLPRFPG ARSHRGALMD SQQASGTIVQ IVINNKHKHG QVCVSNGKTY SHGESWHPNL
RAFGIVECVL CTCNVTKQEC KKIHCPNRYP CKYPQKIDGK CCKVCPGKKA KEELPGQSFD
SKGYFCGEET MPVYESVFME DGETTRKIAL ETERPPQVEV HVWTIRKGIL QHFHIEKISK
RMFEELHHFK LVTRTTLSQW KIFTEGEAQI SQMCSSRVCR TELEDLVKVL YLERGARSSH
IF
//
