ID A0A337S5V5_FELCA Unreviewed; 960 AA.
AC A0A337S5V5;
DT 10-OCT-2018, integrated into UniProtKB/TrEMBL.
DT 11-DEC-2019, sequence version 2.
DT 24-JAN-2024, entry version 22.
DE SubName: Full=Sorting nexin 14 {ECO:0000313|Ensembl:ENSFCAP00000045695.2};
GN Name=SNX14 {ECO:0000313|Ensembl:ENSFCAP00000045695.2,
GN ECO:0000313|VGNC:VGNC:65545};
OS Felis catus (Cat) (Felis silvestris catus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Carnivora; Feliformia; Felidae; Felinae; Felis.
OX NCBI_TaxID=9685 {ECO:0000313|Ensembl:ENSFCAP00000045695.2, ECO:0000313|Proteomes:UP000011712};
RN [1] {ECO:0000313|Ensembl:ENSFCAP00000045695.2, ECO:0000313|Proteomes:UP000011712}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Abyssinian {ECO:0000313|Ensembl:ENSFCAP00000045695.2,
RC ECO:0000313|Proteomes:UP000011712};
RX PubMed=17975172; DOI=10.1101/gr.6380007;
RA Pontius J.U., Mullikin J.C., Smith D.R., Lindblad-Toh K., Gnerre S.,
RA Clamp M., Chang J., Stephens R., Neelam B., Volfovsky N., Schaffer A.A.,
RA Agarwala R., Narfstrom K., Murphy W.J., Giger U., Roca A.L., Antunes A.,
RA Menotti-Raymond M., Yuhki N., Pecon-Slattery J., Johnson W.E., Bourque G.,
RA Tesler G., O'Brien S.J.;
RT "Initial sequence and comparative analysis of the cat genome.";
RL Genome Res. 17:1675-1689(2007).
RN [2] {ECO:0000313|Ensembl:ENSFCAP00000045695.2, ECO:0000313|Proteomes:UP000011712}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Abyssinian {ECO:0000313|Ensembl:ENSFCAP00000045695.2,
RC ECO:0000313|Proteomes:UP000011712};
RA Hillier L.W., Warren W., Obrien S., Wilson R.K.;
RT "Sequence assembly of the Felis catus genome version 6.2.";
RL Submitted (SEP-2011) to the EMBL/GenBank/DDBJ databases.
RN [3] {ECO:0000313|Ensembl:ENSFCAP00000045695.2}
RP IDENTIFICATION.
RC STRAIN=breed Abyssinian {ECO:0000313|Ensembl:ENSFCAP00000045695.2};
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the sorting nexin family.
CC {ECO:0000256|ARBA:ARBA00010883}.
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DR EMBL; AANG04003966; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; A0A337S5V5; -.
DR Ensembl; ENSFCAT00000062181.2; ENSFCAP00000045695.2; ENSFCAG00000006910.6.
DR VGNC; VGNC:65545; SNX14.
DR GeneTree; ENSGT00950000182856; -.
DR Proteomes; UP000011712; Chromosome B2.
DR Bgee; ENSFCAG00000006910; Expressed in brain and 10 other cell types or tissues.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0080025; F:phosphatidylinositol-3,5-bisphosphate binding; IEA:InterPro.
DR CDD; cd06877; PX_SNX14; 1.
DR CDD; cd08722; RGS_SNX14; 1.
DR Gene3D; 3.30.1520.10; Phox-like domain; 1.
DR Gene3D; 1.10.167.10; Regulator of G-protein Signalling 4, domain 2; 1.
DR InterPro; IPR003114; Phox_assoc.
DR InterPro; IPR001683; PX_dom.
DR InterPro; IPR036871; PX_dom_sf.
DR InterPro; IPR016137; RGS.
DR InterPro; IPR036305; RGS_sf.
DR InterPro; IPR044926; RGS_subdomain_2.
DR InterPro; IPR037436; SNX14_PX.
DR InterPro; IPR037892; SNX14_RGS.
DR InterPro; IPR013937; Sorting_nexin_C.
DR PANTHER; PTHR22775; SORTING NEXIN; 1.
DR PANTHER; PTHR22775:SF44; SORTING NEXIN-14; 1.
DR Pfam; PF08628; Nexin_C; 1.
DR Pfam; PF00787; PX; 1.
DR Pfam; PF02194; PXA; 1.
DR Pfam; PF00615; RGS; 1.
DR SMART; SM00312; PX; 1.
DR SMART; SM00313; PXA; 1.
DR SMART; SM00315; RGS; 1.
DR SUPFAM; SSF64268; PX domain; 1.
DR SUPFAM; SSF48097; Regulator of G-protein signaling, RGS; 1.
DR PROSITE; PS50195; PX; 1.
DR PROSITE; PS51207; PXA; 1.
DR PROSITE; PS50132; RGS; 1.
PE 3: Inferred from homology;
KW Membrane {ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000011712};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 48..65
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 72..91
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 150..324
FT /note="PXA"
FT /evidence="ECO:0000259|PROSITE:PS51207"
FT DOMAIN 356..488
FT /note="RGS"
FT /evidence="ECO:0000259|PROSITE:PS50132"
FT DOMAIN 581..701
FT /note="PX"
FT /evidence="ECO:0000259|PROSITE:PS50195"
SQ SEQUENCE 960 AA; 111509 MW; 7A83C1D2A45798E7 CRC64;
MGVASTSAST CSTASATQTE MVPWVRTMGE KLKQRLRLDV GREICRQYPL FCFLLLCLSV
ASLLLNRYLH VLMIFWSFVA GVVTFYCSLG PDSLLPNIFF TIKYKPKQLG LQELFPQGRS
CAVCGKVKCK RHRPSLLLEN YQPWLDLKIS SKVDASLSEV LELVLENFVY PWYRDVTDDE
SFVDELRITL RFFASVLIRR IHKVDIPSII TKKLLKAAMK HIEVIVKASQ KVENTEFLQQ
AALEEYGPEL HVALRSRRDE LHYLRKLTEL LFPYILPPKA TDCRSLTLLL REILSGSVFL
PSLDFLADPD TVNHLLIIFI DDSPPEKATE LPSPLVPFLQ KFAEPRNKKP SVLKLELKQI
REQQDLLFRF MNFLKQEGAV HVLQICLTVE EFNDRILRPE LSNDEMLSLH EELQKIYKTY
CLDESIDKIR FDPFIVEEIQ KIAEGPYIDV VKLQTMRCLF EAYEHVLSLL ENVFTPMFCH
SDEYFRQLLR GAESPTRNSK LNRSTQKRGE SFGISRIGSK IKGVFKSTTM EGAMLPNYGL
AEGEDDFIEE GIVVMEDDSP VEAVSTPNTP RNLAAWKISI PYVDFFEDPS SERKEKKERI
PVFCIDVERN DRRAVGHEPE HWSVYRRYLE FYVLESKLTE FHGTFPDAQL PSKRIIGPKN
YEFLKSKREE FQEYLQKLLQ HPELSNSQLL ADFLSPNGGE TQFLDKILPD VNLGKIIKSV
PGKLMKEKGQ HLEPFIMNFI NSCESPKPKP SKPELTILSP TSENNKKLFS DLFKNNANRA
ENTERKQNQN YFMEMMTVEG VYDYLMYVGR VVFQVPDWLH HLLMGTRILF KNTLEMYTDY
YLHCKLEQLF QEHRLVSLIT LLRDAVFCEN TEPRSLQDKQ KRAKQTFEEM MNYIPDLIVK
CIGEEAKYES IRLLFDGLQQ PVLNKQLTYV LLDIVIQELF PELNKVTEKQ QFYSLFLMVC
//
