ID A0A337S6D7_FELCA Unreviewed; 931 AA.
AC A0A337S6D7;
DT 10-OCT-2018, integrated into UniProtKB/TrEMBL.
DT 10-OCT-2018, sequence version 1.
DT 27-MAR-2024, entry version 23.
DE SubName: Full=Semaphorin 6C {ECO:0000313|Ensembl:ENSFCAP00000045906.1};
GN Name=SEMA6C {ECO:0000313|Ensembl:ENSFCAP00000045906.1,
GN ECO:0000313|VGNC:VGNC:80355};
OS Felis catus (Cat) (Felis silvestris catus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Carnivora; Feliformia; Felidae; Felinae; Felis.
OX NCBI_TaxID=9685 {ECO:0000313|Ensembl:ENSFCAP00000045906.1, ECO:0000313|Proteomes:UP000011712};
RN [1] {ECO:0000313|Ensembl:ENSFCAP00000045906.1, ECO:0000313|Proteomes:UP000011712}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Abyssinian {ECO:0000313|Ensembl:ENSFCAP00000045906.1,
RC ECO:0000313|Proteomes:UP000011712};
RX PubMed=17975172; DOI=10.1101/gr.6380007;
RA Pontius J.U., Mullikin J.C., Smith D.R., Lindblad-Toh K., Gnerre S.,
RA Clamp M., Chang J., Stephens R., Neelam B., Volfovsky N., Schaffer A.A.,
RA Agarwala R., Narfstrom K., Murphy W.J., Giger U., Roca A.L., Antunes A.,
RA Menotti-Raymond M., Yuhki N., Pecon-Slattery J., Johnson W.E., Bourque G.,
RA Tesler G., O'Brien S.J.;
RT "Initial sequence and comparative analysis of the cat genome.";
RL Genome Res. 17:1675-1689(2007).
RN [2] {ECO:0000313|Ensembl:ENSFCAP00000045906.1, ECO:0000313|Proteomes:UP000011712}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Abyssinian {ECO:0000313|Ensembl:ENSFCAP00000045906.1,
RC ECO:0000313|Proteomes:UP000011712};
RA Hillier L.W., Warren W., Obrien S., Wilson R.K.;
RT "Sequence assembly of the Felis catus genome version 6.2.";
RL Submitted (SEP-2011) to the EMBL/GenBank/DDBJ databases.
RN [3] {ECO:0000313|Ensembl:ENSFCAP00000045906.1}
RP IDENTIFICATION.
RC STRAIN=breed Abyssinian {ECO:0000313|Ensembl:ENSFCAP00000045906.1};
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00352}.
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DR EMBL; AANG04001280; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; A0A337S6D7; -.
DR PaxDb; 9685-ENSFCAP00000005156; -.
DR Ensembl; ENSFCAT00000053872.2; ENSFCAP00000045906.1; ENSFCAG00000005557.5.
DR VGNC; VGNC:80355; SEMA6C.
DR GeneTree; ENSGT00940000158641; -.
DR Proteomes; UP000011712; Chromosome C1.
DR Bgee; ENSFCAG00000005557; Expressed in testis and 10 other cell types or tissues.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0030215; F:semaphorin receptor binding; IEA:InterPro.
DR GO; GO:0030154; P:cell differentiation; IEA:UniProtKB-KW.
DR GO; GO:0007399; P:nervous system development; IEA:UniProtKB-KW.
DR Gene3D; 3.30.1680.10; ligand-binding face of the semaphorins, domain 2; 1.
DR Gene3D; 2.130.10.10; YVTN repeat-like/Quinoprotein amine dehydrogenase; 1.
DR InterPro; IPR002165; Plexin_repeat.
DR InterPro; IPR001627; Semap_dom.
DR InterPro; IPR036352; Semap_dom_sf.
DR InterPro; IPR027231; Semaphorin.
DR InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR PANTHER; PTHR11036; SEMAPHORIN; 1.
DR PANTHER; PTHR11036:SF11; SEMAPHORIN-6C; 1.
DR Pfam; PF01437; PSI; 1.
DR Pfam; PF01403; Sema; 1.
DR SMART; SM00630; Sema; 1.
DR SUPFAM; SSF103575; Plexin repeat; 1.
DR SUPFAM; SSF101912; Sema domain; 1.
DR PROSITE; PS51004; SEMA; 1.
PE 4: Predicted;
KW Developmental protein {ECO:0000256|ARBA:ARBA00022473};
KW Differentiation {ECO:0000256|ARBA:ARBA00022782};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Membrane {ECO:0000256|ARBA:ARBA00023136};
KW Neurogenesis {ECO:0000256|ARBA:ARBA00022902};
KW Reference proteome {ECO:0000313|Proteomes:UP000011712};
KW Signal {ECO:0000256|SAM:SignalP}.
FT SIGNAL 1..22
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 23..931
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5016268532"
FT DOMAIN 28..514
FT /note="Sema"
FT /evidence="ECO:0000259|PROSITE:PS51004"
FT REGION 548..587
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 655..675
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 715..739
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 826..876
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 903..931
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 556..582
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 910..924
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 931 AA; 99629 MW; 48F20F518AFBFF98 CRC64;
MPRAPRFMPL LLLLLSLPHT QAAFPQDPLP LLTSDLQGTS PLSWFRGLED DAVVAELGLD
FQRFLTLNRT LLVAARDHVF SFDLQAQEAG EGLVPNKYLT WRSQDMENCV VRGKLTDECH
NYIRVLVPWD SQTLLACGTN SFSPVCRSYG ITSLQQEGEE LSGQARCPFD ATQSNVAIFA
EGSLYSATAA DFQASDAVVY RSLGPQPPLR SAKYDSKWLR EPHFVHALEH GDHVYFFFRE
VSVEDARLGR VQFSRVARVC KRDMGGSPRA LDRHWTSFLK LRLNCSVPGD STFYFDVLQA
LTGPVNLYGR SALFGVFTTQ TNSIPGSAVC AFYLDDIEHA FEGKFKEQRS LDGAWTPVSE
DRVPSPRPGS CAGVGVAALF PSSRDLPDDV LTFIKAHPLL DPAVPPATHQ PLLTLTSRAL
LTQLAVDGRA GPYGNTTVLF LGSEDGTVLK VLPPGGPSGG PEPILLEEIN AYSPARCSGK
RAAQTARRVI GLELDTEGHR LFVAFSGCII YLPLSRCARH GACQRSCLAS QDPYCGWHSS
RGCVDIRGPG GTDVDPAGNQ ESTEHSDCQD GATGSQSGTG DSAYGVRRDL PPASASLSVP
IPLLLACAAA AFALGASVSG LLVSCACRRA HRRRSKDVET PGLPRPLSLR SLARLHGAGP
EPPQSKDGDG AQPPQLYTTF LPPPEGVAPP ELACLPTPES TPELPAKHLR HAGGPWEWNQ
NGNNAKEGQG RARGGNAAGG PAPRVLVRPP PPGCPGQAVE VTTLEELLRY LHGPQPPRKG
AEPLAAAAFT SRALPPEPSP TPTLFAGPSL LPRECGPPLR LDVPPEGKCA APSTRPALSA
PAPRLGVGGG RRTPFPTHRA PPALLTRVPS GGPSRYCGGP GRHLLYLGRP EGYRGRALKR
VDVEKPQLPP KSPLVAPSPP PAIPNGSHFH F
//
