ID A0A337S777_FELCA Unreviewed; 748 AA.
AC A0A337S777;
DT 10-OCT-2018, integrated into UniProtKB/TrEMBL.
DT 11-DEC-2019, sequence version 2.
DT 24-JAN-2024, entry version 27.
DE SubName: Full=BTB domain and CNC homolog 1 {ECO:0000313|Ensembl:ENSFCAP00000041694.2};
GN Name=BACH1 {ECO:0000313|Ensembl:ENSFCAP00000041694.2,
GN ECO:0000313|VGNC:VGNC:69035};
OS Felis catus (Cat) (Felis silvestris catus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Carnivora; Feliformia; Felidae; Felinae; Felis.
OX NCBI_TaxID=9685 {ECO:0000313|Ensembl:ENSFCAP00000041694.2, ECO:0000313|Proteomes:UP000011712};
RN [1] {ECO:0000313|Ensembl:ENSFCAP00000041694.2, ECO:0000313|Proteomes:UP000011712}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Abyssinian {ECO:0000313|Ensembl:ENSFCAP00000041694.2,
RC ECO:0000313|Proteomes:UP000011712};
RX PubMed=17975172; DOI=10.1101/gr.6380007;
RA Pontius J.U., Mullikin J.C., Smith D.R., Lindblad-Toh K., Gnerre S.,
RA Clamp M., Chang J., Stephens R., Neelam B., Volfovsky N., Schaffer A.A.,
RA Agarwala R., Narfstrom K., Murphy W.J., Giger U., Roca A.L., Antunes A.,
RA Menotti-Raymond M., Yuhki N., Pecon-Slattery J., Johnson W.E., Bourque G.,
RA Tesler G., O'Brien S.J.;
RT "Initial sequence and comparative analysis of the cat genome.";
RL Genome Res. 17:1675-1689(2007).
RN [2] {ECO:0000313|Ensembl:ENSFCAP00000041694.2, ECO:0000313|Proteomes:UP000011712}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Abyssinian {ECO:0000313|Ensembl:ENSFCAP00000041694.2,
RC ECO:0000313|Proteomes:UP000011712};
RA Hillier L.W., Warren W., Obrien S., Wilson R.K.;
RT "Sequence assembly of the Felis catus genome version 6.2.";
RL Submitted (SEP-2011) to the EMBL/GenBank/DDBJ databases.
RN [3] {ECO:0000313|Ensembl:ENSFCAP00000041694.2}
RP IDENTIFICATION.
RC STRAIN=breed Abyssinian {ECO:0000313|Ensembl:ENSFCAP00000041694.2};
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
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DR EMBL; AANG04001815; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR RefSeq; XP_006935997.1; XM_006935935.3.
DR RefSeq; XP_019695026.1; XM_019839467.1.
DR AlphaFoldDB; A0A337S777; -.
DR STRING; 9685.ENSFCAP00000041694; -.
DR PaxDb; 9685-ENSFCAP00000017495; -.
DR Ensembl; ENSFCAT00000056138.2; ENSFCAP00000041694.2; ENSFCAG00000010547.6.
DR GeneID; 101097412; -.
DR KEGG; fca:101097412; -.
DR CTD; 571; -.
DR VGNC; VGNC:69035; BACH1.
DR GeneTree; ENSGT00940000158923; -.
DR InParanoid; A0A337S777; -.
DR OMA; RRSECPW; -.
DR OrthoDB; 382726at2759; -.
DR Proteomes; UP000011712; Chromosome C2.
DR Bgee; ENSFCAG00000010547; Expressed in embryonic head and 10 other cell types or tissues.
DR GO; GO:0090575; C:RNA polymerase II transcription regulator complex; IEA:Ensembl.
DR GO; GO:0001228; F:DNA-binding transcription activator activity, RNA polymerase II-specific; IEA:Ensembl.
DR GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IBA:GO_Central.
DR GO; GO:0001227; F:DNA-binding transcription repressor activity, RNA polymerase II-specific; IEA:Ensembl.
DR GO; GO:0098531; F:ligand-activated transcription factor activity; IEA:Ensembl.
DR GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IBA:GO_Central.
DR GO; GO:0006281; P:DNA repair; IEA:Ensembl.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR CDD; cd18277; BTB_POZ_BACH1; 1.
DR CDD; cd14719; bZIP_BACH; 1.
DR Gene3D; 1.10.880.10; Transcription factor, Skn-1-like, DNA-binding domain; 1.
DR InterPro; IPR000210; BTB/POZ_dom.
DR InterPro; IPR004827; bZIP.
DR InterPro; IPR043321; bZIP_BACH.
DR InterPro; IPR004826; bZIP_Maf.
DR InterPro; IPR046347; bZIP_sf.
DR InterPro; IPR011333; SKP1/BTB/POZ_sf.
DR InterPro; IPR008917; TF_DNA-bd_sf.
DR PANTHER; PTHR46105; AGAP004733-PA; 1.
DR PANTHER; PTHR46105:SF1; TRANSCRIPTION REGULATOR PROTEIN BACH1; 1.
DR Pfam; PF00651; BTB; 1.
DR Pfam; PF03131; bZIP_Maf; 1.
DR SMART; SM00338; BRLZ; 1.
DR SMART; SM00225; BTB; 1.
DR SUPFAM; SSF47454; A DNA-binding domain in eukaryotic transcription factors; 1.
DR SUPFAM; SSF57959; Leucine zipper domain; 1.
DR SUPFAM; SSF54695; POZ domain; 1.
DR PROSITE; PS50097; BTB; 1.
DR PROSITE; PS50217; BZIP; 1.
DR PROSITE; PS00036; BZIP_BASIC; 1.
PE 4: Predicted;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Reference proteome {ECO:0000313|Proteomes:UP000011712};
KW Transcription {ECO:0000256|ARBA:ARBA00023163};
KW Transcription regulation {ECO:0000256|ARBA:ARBA00023015}.
FT DOMAIN 34..100
FT /note="BTB"
FT /evidence="ECO:0000259|PROSITE:PS50097"
FT DOMAIN 567..625
FT /note="BZIP"
FT /evidence="ECO:0000259|PROSITE:PS50217"
FT REGION 239..260
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 288..307
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 352..393
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 662..748
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 580..614
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 355..379
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 683..697
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 734..748
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 748 AA; 82407 MW; 276AE771EBDDAD17 CRC64;
MSLSENAVFA YESSVHSTNV LLGLNDQRKK DVLCDVTVLV EGQRYRAHRS VLAACSSYFH
SRIVGQADAE LSITLPEEVT VKGFEPLIQF AYTAKLILSK DNVDEVCKCV EFLGVRDIEE
SCFQFLKFKF LDSTADQQEC LRKKCIPSHC QKADLKFSLL DQRDLEIDDV EEFLENKNVQ
TPQWKLHRYQ GNAKVSSPLQ DSASQTCESM CLEKDAALAL PSLCPKYRKF QKAFGTDRVR
SAESSGKDVH ASAQPNETPE NECLGGIQDC ADLQVILKCE EGKLAMEHEE TKKKDPAPQC
PSEKPEMTPF PHNSSAAPHG LYSLSLLHTY DQYGDGDVSF AGMQNTAVLT EKPLSGTDVR
EEKTFGESQD LHLKSDSGPR EDGSLASSDR SSVEREVAEH LAKGFWSDIC STDSPCQMQL
SPAVAKDGSE QIYSQKRSEC PWLGIRISES PEPGQRTFTT LSSVNCPFIS TLSTEGCSSS
LEIGNDEYVS EPQQEPCPYA CVISLGDDSE TDTEGDSEPC SAREQECEVK LPFNAQRIIS
LSRNDFQSLL KMHKLTPEQL DCIHDIRRRS KNRIAAQRCR KRKLDCIQNL ESEIEKLQNE
KESLLKERDH ILSTLGETKQ NLTGLCQQVC KEAALSQEQI QILAKYSASD CPLSFLVSEK
EKSTPDGELA LPSILSLPEG PPAALPAGEP SPRHPHPGPK GGGSAGCAPG ESRLPAAPEQ
AGPSEPCRQG GGISDFCQQM TDKCTTDE
//
