ID A0A337SB81_FELCA Unreviewed; 629 AA.
AC A0A337SB81;
DT 10-OCT-2018, integrated into UniProtKB/TrEMBL.
DT 10-OCT-2018, sequence version 1.
DT 27-MAR-2024, entry version 22.
DE SubName: Full=Semaphorin 4A {ECO:0000313|Ensembl:ENSFCAP00000043071.1};
GN Name=SEMA4A {ECO:0000313|Ensembl:ENSFCAP00000043071.1,
GN ECO:0000313|VGNC:VGNC:64992};
OS Felis catus (Cat) (Felis silvestris catus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Carnivora; Feliformia; Felidae; Felinae; Felis.
OX NCBI_TaxID=9685 {ECO:0000313|Ensembl:ENSFCAP00000043071.1, ECO:0000313|Proteomes:UP000011712};
RN [1] {ECO:0000313|Ensembl:ENSFCAP00000043071.1, ECO:0000313|Proteomes:UP000011712}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Abyssinian {ECO:0000313|Ensembl:ENSFCAP00000043071.1,
RC ECO:0000313|Proteomes:UP000011712};
RX PubMed=17975172; DOI=10.1101/gr.6380007;
RA Pontius J.U., Mullikin J.C., Smith D.R., Lindblad-Toh K., Gnerre S.,
RA Clamp M., Chang J., Stephens R., Neelam B., Volfovsky N., Schaffer A.A.,
RA Agarwala R., Narfstrom K., Murphy W.J., Giger U., Roca A.L., Antunes A.,
RA Menotti-Raymond M., Yuhki N., Pecon-Slattery J., Johnson W.E., Bourque G.,
RA Tesler G., O'Brien S.J.;
RT "Initial sequence and comparative analysis of the cat genome.";
RL Genome Res. 17:1675-1689(2007).
RN [2] {ECO:0000313|Ensembl:ENSFCAP00000043071.1, ECO:0000313|Proteomes:UP000011712}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Abyssinian {ECO:0000313|Ensembl:ENSFCAP00000043071.1,
RC ECO:0000313|Proteomes:UP000011712};
RA Hillier L.W., Warren W., Obrien S., Wilson R.K.;
RT "Sequence assembly of the Felis catus genome version 6.2.";
RL Submitted (SEP-2011) to the EMBL/GenBank/DDBJ databases.
RN [3] {ECO:0000313|Ensembl:ENSFCAP00000043071.1}
RP IDENTIFICATION.
RC STRAIN=breed Abyssinian {ECO:0000313|Ensembl:ENSFCAP00000043071.1};
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00352}.
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DR EMBL; AANG04002876; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; A0A337SB81; -.
DR Ensembl; ENSFCAT00000050517.2; ENSFCAP00000043071.1; ENSFCAG00000011779.6.
DR VGNC; VGNC:64992; SEMA4A.
DR GeneTree; ENSGT00940000161509; -.
DR Proteomes; UP000011712; Chromosome F1.
DR Bgee; ENSFCAG00000011779; Expressed in spleen and 10 other cell types or tissues.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0030215; F:semaphorin receptor binding; IEA:InterPro.
DR GO; GO:0030154; P:cell differentiation; IEA:UniProtKB-KW.
DR GO; GO:0007399; P:nervous system development; IEA:UniProtKB-KW.
DR Gene3D; 3.30.1680.10; ligand-binding face of the semaphorins, domain 2; 1.
DR Gene3D; 2.130.10.10; YVTN repeat-like/Quinoprotein amine dehydrogenase; 1.
DR InterPro; IPR002165; Plexin_repeat.
DR InterPro; IPR016201; PSI.
DR InterPro; IPR001627; Semap_dom.
DR InterPro; IPR036352; Semap_dom_sf.
DR InterPro; IPR027231; Semaphorin.
DR InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR PANTHER; PTHR11036; SEMAPHORIN; 1.
DR PANTHER; PTHR11036:SF15; SEMAPHORIN-4A; 1.
DR Pfam; PF01437; PSI; 1.
DR Pfam; PF01403; Sema; 1.
DR SMART; SM00423; PSI; 1.
DR SMART; SM00630; Sema; 1.
DR SUPFAM; SSF103575; Plexin repeat; 1.
DR SUPFAM; SSF101912; Sema domain; 1.
DR PROSITE; PS51004; SEMA; 1.
PE 4: Predicted;
KW Developmental protein {ECO:0000256|ARBA:ARBA00022473};
KW Differentiation {ECO:0000256|ARBA:ARBA00022782};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Neurogenesis {ECO:0000256|ARBA:ARBA00022902};
KW Reference proteome {ECO:0000313|Proteomes:UP000011712};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 548..571
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 1..362
FT /note="Sema"
FT /evidence="ECO:0000259|PROSITE:PS51004"
FT REGION 589..629
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 629 AA; 68949 MW; 5B06E0B5D9EF30F4 CRC64;
MIPWPASDQK KRECAFKKKS NEELQDSYLM PISQDKVVEG KGQSPFDPAH KHTAVLADGM
LYSGTMNNFL GSEPILIRTL GPQPVLKTDN FLRWLQPDAS FVAAIPSTHF VYFFFEETAS
EFEFFEKLHT SRVARVCKND VGGDKLLQKK WTTFLKAQLL CAQPGQLPFN VVRHAVLLPA
TASADARVYA TFSSQWQIGG TRSSAVCAFS LKDFRRVFEG KYKELNKETS RWTTYGVPEI
SPRPGSCSVG PSSDKALTFM KDHFLMDEQV VGTPVLVKSG VEYTRLAVET VQGVDGHSHL
VMYLGTTTGS LHKAVGSGNN SVHLVEEIQL FPEPEPVRNL LLAPAQGAVF AGSSRGIWRV
PRANCSVYES CVDCVLARDP HCAWDPESRT CRLLPTPIPK SWRQDMEQGN PRFACATGPV
GRSRQPQSRP EIIKEVLSVP NSIVELPCPR LSALASYRWS HGKAAVPEAS AAVYNGSLLL
LLQDGVGGLY QCWATENDFS YPVVSYWVHS QDQPLALDPE LAGIPRERVE APLTRVGGGA
ALAAQRSYWP HFLTVTVLLA LVLSGALLLL LASPLGALRA RGKVRGCETL PPGEKAPLSR
KQHLQPPKDH TTSAGEVDAD NNHLGSEVA
//
