ID A0A337SBE9_FELCA Unreviewed; 421 AA.
AC A0A337SBE9;
DT 10-OCT-2018, integrated into UniProtKB/TrEMBL.
DT 10-OCT-2018, sequence version 1.
DT 24-JAN-2024, entry version 27.
DE SubName: Full=Nerve growth factor receptor {ECO:0000313|Ensembl:ENSFCAP00000044299.1};
GN Name=NGFR {ECO:0000313|Ensembl:ENSFCAP00000044299.1,
GN ECO:0000313|VGNC:VGNC:99290};
OS Felis catus (Cat) (Felis silvestris catus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Carnivora; Feliformia; Felidae; Felinae; Felis.
OX NCBI_TaxID=9685 {ECO:0000313|Ensembl:ENSFCAP00000044299.1, ECO:0000313|Proteomes:UP000011712};
RN [1] {ECO:0000313|Ensembl:ENSFCAP00000044299.1, ECO:0000313|Proteomes:UP000011712}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Abyssinian {ECO:0000313|Ensembl:ENSFCAP00000044299.1,
RC ECO:0000313|Proteomes:UP000011712};
RX PubMed=17975172; DOI=10.1101/gr.6380007;
RA Pontius J.U., Mullikin J.C., Smith D.R., Lindblad-Toh K., Gnerre S.,
RA Clamp M., Chang J., Stephens R., Neelam B., Volfovsky N., Schaffer A.A.,
RA Agarwala R., Narfstrom K., Murphy W.J., Giger U., Roca A.L., Antunes A.,
RA Menotti-Raymond M., Yuhki N., Pecon-Slattery J., Johnson W.E., Bourque G.,
RA Tesler G., O'Brien S.J.;
RT "Initial sequence and comparative analysis of the cat genome.";
RL Genome Res. 17:1675-1689(2007).
RN [2] {ECO:0000313|Ensembl:ENSFCAP00000044299.1, ECO:0000313|Proteomes:UP000011712}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Abyssinian {ECO:0000313|Ensembl:ENSFCAP00000044299.1,
RC ECO:0000313|Proteomes:UP000011712};
RA Hillier L.W., Warren W., Obrien S., Wilson R.K.;
RT "Sequence assembly of the Felis catus genome version 6.2.";
RL Submitted (SEP-2011) to the EMBL/GenBank/DDBJ databases.
RN [3] {ECO:0000313|Ensembl:ENSFCAP00000044299.1}
RP IDENTIFICATION.
RC STRAIN=breed Abyssinian {ECO:0000313|Ensembl:ENSFCAP00000044299.1};
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00206}.
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DR EMBL; AANG04003358; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; A0A337SBE9; -.
DR SMR; A0A337SBE9; -.
DR STRING; 9685.ENSFCAP00000044299; -.
DR PaxDb; 9685-ENSFCAP00000012713; -.
DR Ensembl; ENSFCAT00000066945.2; ENSFCAP00000044299.1; ENSFCAG00000046296.2.
DR VGNC; VGNC:99290; NGFR.
DR GeneTree; ENSGT00730000110974; -.
DR InParanoid; A0A337SBE9; -.
DR OMA; YSCQDKQ; -.
DR Proteomes; UP000011712; Chromosome E1.
DR Bgee; ENSFCAG00000046296; Expressed in embryonic head and 7 other cell types or tissues.
DR GO; GO:0009986; C:cell surface; IBA:GO_Central.
DR GO; GO:0005911; C:cell-cell junction; IEA:Ensembl.
DR GO; GO:0005737; C:cytoplasm; IEA:Ensembl.
DR GO; GO:0031594; C:neuromuscular junction; IEA:Ensembl.
DR GO; GO:0005654; C:nucleoplasm; IEA:Ensembl.
DR GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
DR GO; GO:0014069; C:postsynaptic density; IEA:Ensembl.
DR GO; GO:0098793; C:presynapse; IEA:GOC.
DR GO; GO:0005516; F:calmodulin binding; IEA:Ensembl.
DR GO; GO:0015026; F:coreceptor activity; IBA:GO_Central.
DR GO; GO:0005035; F:death receptor activity; IBA:GO_Central.
DR GO; GO:0048406; F:nerve growth factor binding; IBA:GO_Central.
DR GO; GO:0031267; F:small GTPase binding; IEA:Ensembl.
DR GO; GO:0031625; F:ubiquitin protein ligase binding; IEA:Ensembl.
DR GO; GO:0007411; P:axon guidance; IEA:Ensembl.
DR GO; GO:1904646; P:cellular response to amyloid-beta; IEA:Ensembl.
DR GO; GO:0007417; P:central nervous system development; IEA:Ensembl.
DR GO; GO:0032922; P:circadian regulation of gene expression; IEA:Ensembl.
DR GO; GO:0016048; P:detection of temperature stimulus; IEA:Ensembl.
DR GO; GO:0035907; P:dorsal aorta development; IEA:Ensembl.
DR GO; GO:0008543; P:fibroblast growth factor receptor signaling pathway; IEA:Ensembl.
DR GO; GO:0048144; P:fibroblast proliferation; IEA:Ensembl.
DR GO; GO:0031069; P:hair follicle morphogenesis; IEA:Ensembl.
DR GO; GO:0001678; P:intracellular glucose homeostasis; IEA:Ensembl.
DR GO; GO:0006886; P:intracellular protein transport; IEA:Ensembl.
DR GO; GO:1903588; P:negative regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis; IEA:Ensembl.
DR GO; GO:0030336; P:negative regulation of cell migration; IEA:Ensembl.
DR GO; GO:0040037; P:negative regulation of fibroblast growth factor receptor signaling pathway; IEA:Ensembl.
DR GO; GO:0051799; P:negative regulation of hair follicle development; IEA:Ensembl.
DR GO; GO:0021675; P:nerve development; IEA:Ensembl.
DR GO; GO:0051402; P:neuron apoptotic process; IEA:Ensembl.
DR GO; GO:0042475; P:odontogenesis of dentin-containing tooth; IEA:Ensembl.
DR GO; GO:2001235; P:positive regulation of apoptotic signaling pathway; IEA:Ensembl.
DR GO; GO:0048146; P:positive regulation of fibroblast proliferation; IEA:Ensembl.
DR GO; GO:1902895; P:positive regulation of miRNA transcription; IEA:Ensembl.
DR GO; GO:0042488; P:positive regulation of odontogenesis of dentin-containing tooth; IEA:Ensembl.
DR GO; GO:1900182; P:positive regulation of protein localization to nucleus; IEA:Ensembl.
DR GO; GO:0099171; P:presynaptic modulation of chemical synaptic transmission; IEA:Ensembl.
DR GO; GO:0007266; P:Rho protein signal transduction; IBA:GO_Central.
DR CDD; cd08311; Death_p75NR; 1.
DR CDD; cd13416; TNFRSF16; 1.
DR Gene3D; 6.10.250.1780; -; 1.
DR Gene3D; 1.10.533.10; Death Domain, Fas; 1.
DR Gene3D; 2.10.50.10; Tumor Necrosis Factor Receptor, subunit A, domain 2; 4.
DR InterPro; IPR011029; DEATH-like_dom_sf.
DR InterPro; IPR000488; Death_domain.
DR InterPro; IPR001368; TNFR/NGFR_Cys_rich_reg.
DR InterPro; IPR041448; TNFR16_TM.
DR InterPro; IPR022325; TNFR_16.
DR InterPro; IPR034046; TNFRSF16_N.
DR PANTHER; PTHR46605; TUMOR NECROSIS FACTOR RECEPTOR; 1.
DR PANTHER; PTHR46605:SF3; TUMOR NECROSIS FACTOR RECEPTOR SUPERFAMILY MEMBER 16; 1.
DR Pfam; PF00531; Death; 1.
DR Pfam; PF18422; TNFR_16_TM; 1.
DR Pfam; PF00020; TNFR_c6; 3.
DR PRINTS; PR01966; TNFACTORR16.
DR SMART; SM00005; DEATH; 1.
DR SMART; SM00208; TNFR; 4.
DR SUPFAM; SSF47986; DEATH domain; 1.
DR SUPFAM; SSF57586; TNF receptor-like; 4.
DR PROSITE; PS50017; DEATH_DOMAIN; 1.
DR PROSITE; PS00652; TNFR_NGFR_1; 2.
DR PROSITE; PS50050; TNFR_NGFR_2; 4.
PE 4: Predicted;
KW Apoptosis {ECO:0000256|ARBA:ARBA00022703};
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Disulfide bond {ECO:0000256|PROSITE-ProRule:PRU00206};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000011712};
KW Signal {ECO:0000256|ARBA:ARBA00022729, ECO:0000256|SAM:SignalP};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT SIGNAL 1..22
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 23..421
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5016398508"
FT TRANSMEM 246..266
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT REPEAT 25..58
FT /note="TNFR-Cys"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00206"
FT DOMAIN 25..58
FT /note="TNFR-Cys"
FT /evidence="ECO:0000259|PROSITE:PS50050"
FT DOMAIN 60..101
FT /note="TNFR-Cys"
FT /evidence="ECO:0000259|PROSITE:PS50050"
FT REPEAT 60..101
FT /note="TNFR-Cys"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00206"
FT REPEAT 102..140
FT /note="TNFR-Cys"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00206"
FT DOMAIN 102..140
FT /note="TNFR-Cys"
FT /evidence="ECO:0000259|PROSITE:PS50050"
FT REPEAT 142..182
FT /note="TNFR-Cys"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00206"
FT DOMAIN 142..182
FT /note="TNFR-Cys"
FT /evidence="ECO:0000259|PROSITE:PS50050"
FT DOMAIN 338..415
FT /note="Death"
FT /evidence="ECO:0000259|PROSITE:PS50017"
FT REGION 189..214
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 275..325
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 192..208
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 299..320
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT DISULFID 38..51
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00206"
FT DISULFID 80..93
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00206"
FT DISULFID 83..101
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00206"
FT DISULFID 119..132
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00206"
FT DISULFID 122..140
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00206"
FT DISULFID 143..158
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00206"
FT DISULFID 161..174
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00206"
FT DISULFID 164..182
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00206"
SQ SEQUENCE 421 AA; 44703 MW; BA29BC16B19F82CD CRC64;
MDGPRPLLLL LPLLLGVSLG GAKEACPTGL FTHSGECCKA CNLGEGVAQP CGANQTVCEP
CLDSVTFSDV VSATEPCKPC TECVGLQSMS APCVEADDAV CRCAYGYYQD ETTGRCEACR
VCEAGSGLVF SCQDRQNTVC EECPDGTYSD EANHVDPCLP CTVCEDTERQ LRECTRWADA
ECEEIPGRWI TRSTPSEGSD STAPSTEEPE VPPEQDLIAS TVADVVTTVM GSSQPVVTRG
TADNLIPVYC SILAAVVVGL VAYIAFKRWN SCKQDKQGAN SRPVNQTPPP EGEKLHSDSG
ISVDSQSLHD QQSHTQTAAG QALKGDGGLY SSLPSAKREE VEKLLNGSAG DTWRHLAGEL
GYQPEHIDSF TREACPARAL LASWAAQDSA TLDALLAALR RIQRADIVES LCSESTATSP
V
//