ID A0A337SBY4_FELCA Unreviewed; 862 AA.
AC A0A337SBY4;
DT 10-OCT-2018, integrated into UniProtKB/TrEMBL.
DT 10-OCT-2018, sequence version 1.
DT 24-JAN-2024, entry version 22.
DE SubName: Full=Rho guanine nucleotide exchange factor 7 {ECO:0000313|Ensembl:ENSFCAP00000043311.1};
GN Name=ARHGEF7 {ECO:0000313|Ensembl:ENSFCAP00000043311.1,
GN ECO:0000313|VGNC:VGNC:59909};
OS Felis catus (Cat) (Felis silvestris catus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Carnivora; Feliformia; Felidae; Felinae; Felis.
OX NCBI_TaxID=9685 {ECO:0000313|Ensembl:ENSFCAP00000043311.1, ECO:0000313|Proteomes:UP000011712};
RN [1] {ECO:0000313|Ensembl:ENSFCAP00000043311.1, ECO:0000313|Proteomes:UP000011712}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Abyssinian {ECO:0000313|Ensembl:ENSFCAP00000043311.1,
RC ECO:0000313|Proteomes:UP000011712};
RX PubMed=17975172; DOI=10.1101/gr.6380007;
RA Pontius J.U., Mullikin J.C., Smith D.R., Lindblad-Toh K., Gnerre S.,
RA Clamp M., Chang J., Stephens R., Neelam B., Volfovsky N., Schaffer A.A.,
RA Agarwala R., Narfstrom K., Murphy W.J., Giger U., Roca A.L., Antunes A.,
RA Menotti-Raymond M., Yuhki N., Pecon-Slattery J., Johnson W.E., Bourque G.,
RA Tesler G., O'Brien S.J.;
RT "Initial sequence and comparative analysis of the cat genome.";
RL Genome Res. 17:1675-1689(2007).
RN [2] {ECO:0000313|Ensembl:ENSFCAP00000043311.1, ECO:0000313|Proteomes:UP000011712}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Abyssinian {ECO:0000313|Ensembl:ENSFCAP00000043311.1,
RC ECO:0000313|Proteomes:UP000011712};
RA Hillier L.W., Warren W., Obrien S., Wilson R.K.;
RT "Sequence assembly of the Felis catus genome version 6.2.";
RL Submitted (SEP-2011) to the EMBL/GenBank/DDBJ databases.
RN [3] {ECO:0000313|Ensembl:ENSFCAP00000043311.1}
RP IDENTIFICATION.
RC STRAIN=breed Abyssinian {ECO:0000313|Ensembl:ENSFCAP00000043311.1};
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cell projection, lamellipodium
CC {ECO:0000256|ARBA:ARBA00004510}.
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DR EMBL; AANG04001781; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; A0A337SBY4; -.
DR Ensembl; ENSFCAT00000052792.2; ENSFCAP00000043311.1; ENSFCAG00000014533.6.
DR VGNC; VGNC:59909; ARHGEF7.
DR GeneTree; ENSGT00940000155360; -.
DR OrthoDB; 2879064at2759; -.
DR Proteomes; UP000011712; Chromosome A1.
DR Bgee; ENSFCAG00000014533; Expressed in prefrontal cortex and 9 other cell types or tissues.
DR GO; GO:0030027; C:lamellipodium; IEA:UniProtKB-SubCell.
DR GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:UniProtKB-KW.
DR GO; GO:0035556; P:intracellular signal transduction; IEA:InterPro.
DR CDD; cd21266; CH_betaPIX; 1.
DR CDD; cd01225; PH_Cool_Pix; 1.
DR CDD; cd00160; RhoGEF; 1.
DR CDD; cd12061; SH3_betaPIX; 1.
DR Gene3D; 1.10.418.10; Calponin-like domain; 1.
DR Gene3D; 1.20.900.10; Dbl homology (DH) domain; 1.
DR Gene3D; 1.20.5.390; L1 transposable element, trimerization domain; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR Gene3D; 2.30.30.40; SH3 Domains; 1.
DR InterPro; IPR035789; BetaPIX_SH3.
DR InterPro; IPR001715; CH_dom.
DR InterPro; IPR036872; CH_dom_sf.
DR InterPro; IPR035899; DBL_dom_sf.
DR InterPro; IPR000219; DH-domain.
DR InterPro; IPR001331; GDS_CDC24_CS.
DR InterPro; IPR032409; GEF6/7_CC.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR046376; PH_Cool_Pix.
DR InterPro; IPR001849; PH_domain.
DR InterPro; IPR036028; SH3-like_dom_sf.
DR InterPro; IPR001452; SH3_domain.
DR PANTHER; PTHR46026:SF3; RHO GUANINE NUCLEOTIDE EXCHANGE FACTOR 7; 1.
DR PANTHER; PTHR46026; RHO-TYPE GUANINE NUCLEOTIDE EXCHANGE FACTOR, ISOFORM F; 1.
DR Pfam; PF16523; betaPIX_CC; 1.
DR Pfam; PF00307; CH; 1.
DR Pfam; PF00169; PH; 1.
DR Pfam; PF00621; RhoGEF; 1.
DR Pfam; PF16615; RhoGEF67_u1; 1.
DR Pfam; PF16614; RhoGEF67_u2; 1.
DR Pfam; PF07653; SH3_2; 1.
DR PRINTS; PR00452; SH3DOMAIN.
DR SMART; SM00033; CH; 1.
DR SMART; SM00233; PH; 1.
DR SMART; SM00325; RhoGEF; 1.
DR SMART; SM00326; SH3; 1.
DR SUPFAM; SSF47576; Calponin-homology domain, CH-domain; 1.
DR SUPFAM; SSF48065; DBL homology domain (DH-domain); 1.
DR SUPFAM; SSF50729; PH domain-like; 1.
DR SUPFAM; SSF50044; SH3-domain; 1.
DR PROSITE; PS50021; CH; 1.
DR PROSITE; PS00741; DH_1; 1.
DR PROSITE; PS50010; DH_2; 1.
DR PROSITE; PS50003; PH_DOMAIN; 1.
DR PROSITE; PS50002; SH3; 1.
PE 4: Predicted;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Guanine-nucleotide releasing factor {ECO:0000256|ARBA:ARBA00022658};
KW Reference proteome {ECO:0000313|Proteomes:UP000011712};
KW SH3 domain {ECO:0000256|ARBA:ARBA00022443, ECO:0000256|PROSITE-
KW ProRule:PRU00192}.
FT DOMAIN 1..112
FT /note="Calponin-homology (CH)"
FT /evidence="ECO:0000259|PROSITE:PS50021"
FT DOMAIN 163..222
FT /note="SH3"
FT /evidence="ECO:0000259|PROSITE:PS50002"
FT DOMAIN 250..430
FT /note="DH"
FT /evidence="ECO:0000259|PROSITE:PS50010"
FT DOMAIN 452..557
FT /note="PH"
FT /evidence="ECO:0000259|PROSITE:PS50003"
FT REGION 561..629
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 657..677
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 728..752
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 810..851
FT /evidence="ECO:0000256|SAM:Coils"
SQ SEQUENCE 862 AA; 97083 MW; A9B9765BCCA1376D CRC64;
MNSAEQTVTW LITLGVLESP KKTISDPEGF LQASLKDGVV LCRLLERLLP GTIEKVYPEP
RSESECLSNI REFLRGCGAS LRLETFDAND LYQGQNFNKV LSSLVTLNKV TADIGLGSDS
VCARPSSHRI KSFDSLGAQP SHSRTSKLFQ GQYRSLDMTD NSNSQLVVRA KFNFQQTNED
ELSFTKGDII HVTRVEEGGW WEGTHNGRTG WFPSNYVREV KPSEKPVSPK SGTLKSPPKG
FDTTAINKSY YNVVLQNILE TENEYSKELQ TVLSTYLRPL QTSEKLSSAN ISYLMGNLEE
ICSFQQMLVQ SLEECTKLPE AQQRVGGCFL NLMPQMKTLY LAYCANHPSA VNVLTEHSEQ
LGEFMETRGA SSPGILVLTT GLSRPFMRLD KYPTLLKELE RHMEDYHPDR QDIQKSMTAF
KNLSAQCQEV RKRKELELQI LTEAIRSWEG DDITTLGSVV YMSQVMVQCA GSEEKNERYL
LLFPNSLLML SASPRMSGFI YQGKLPTTGM TITKLEDSEN HRNAFEISGS MIERILVSCN
NQQDLHEWVD HLQKQTKVTS VGNPTIKPHS VPSHTLPSHP IAPSGKHADS KPAPLTPAYH
TLPHPSHHGT PHTTINWGPL EPPKTPKPWS LSCLRPAPPL RPSAALCYKE DLSKSPKTMK
KLLPKRKPER KPSDEEFALR KSTAALEEDA QILKVIEAYC TSAKTRQTLN STWQGTDLMH
NHVLADDDQS SLDSLGRRSS LSRLEPSDLS EDSDYDSIWT AHSYRMGSTS RSRKESAPQV
LLPEEEKIIV EETKSNGQTV IEEKSLVDTV YALKDEVQEL RQDNKKMKKS LEEEQRARKD
LEKLVRKVLK NMNDPAWDET NL
//
