ID A0A337SCB2_FELCA Unreviewed; 944 AA.
AC A0A337SCB2;
DT 10-OCT-2018, integrated into UniProtKB/TrEMBL.
DT 10-OCT-2018, sequence version 1.
DT 27-MAR-2024, entry version 22.
DE SubName: Full=DnaJ heat shock protein family (Hsp40) member C6 {ECO:0000313|Ensembl:ENSFCAP00000044606.1};
GN Name=DNAJC6 {ECO:0000313|VGNC:VGNC:80187};
GN Synonyms=LEPROT {ECO:0000313|Ensembl:ENSFCAP00000044606.1};
OS Felis catus (Cat) (Felis silvestris catus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Carnivora; Feliformia; Felidae; Felinae; Felis.
OX NCBI_TaxID=9685 {ECO:0000313|Ensembl:ENSFCAP00000044606.1, ECO:0000313|Proteomes:UP000011712};
RN [1] {ECO:0000313|Ensembl:ENSFCAP00000044606.1, ECO:0000313|Proteomes:UP000011712}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Abyssinian {ECO:0000313|Ensembl:ENSFCAP00000044606.1,
RC ECO:0000313|Proteomes:UP000011712};
RX PubMed=17975172; DOI=10.1101/gr.6380007;
RA Pontius J.U., Mullikin J.C., Smith D.R., Lindblad-Toh K., Gnerre S.,
RA Clamp M., Chang J., Stephens R., Neelam B., Volfovsky N., Schaffer A.A.,
RA Agarwala R., Narfstrom K., Murphy W.J., Giger U., Roca A.L., Antunes A.,
RA Menotti-Raymond M., Yuhki N., Pecon-Slattery J., Johnson W.E., Bourque G.,
RA Tesler G., O'Brien S.J.;
RT "Initial sequence and comparative analysis of the cat genome.";
RL Genome Res. 17:1675-1689(2007).
RN [2] {ECO:0000313|Ensembl:ENSFCAP00000044606.1, ECO:0000313|Proteomes:UP000011712}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Abyssinian {ECO:0000313|Ensembl:ENSFCAP00000044606.1,
RC ECO:0000313|Proteomes:UP000011712};
RA Hillier L.W., Warren W., Obrien S., Wilson R.K.;
RT "Sequence assembly of the Felis catus genome version 6.2.";
RL Submitted (SEP-2011) to the EMBL/GenBank/DDBJ databases.
RN [3] {ECO:0000313|Ensembl:ENSFCAP00000044606.1}
RP IDENTIFICATION.
RC STRAIN=breed Abyssinian {ECO:0000313|Ensembl:ENSFCAP00000044606.1};
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
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DR EMBL; AANG04003279; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; A0A337SCB2; -.
DR PaxDb; 9685-ENSFCAP00000007757; -.
DR Ensembl; ENSFCAT00000051706.2; ENSFCAP00000044606.1; ENSFCAG00000008367.6.
DR VGNC; VGNC:80187; DNAJC6.
DR GeneTree; ENSGT00940000158755; -.
DR Proteomes; UP000011712; Chromosome C1.
DR Bgee; ENSFCAG00000008367; Expressed in brain and 10 other cell types or tissues.
DR GO; GO:0016311; P:dephosphorylation; IEA:InterPro.
DR CDD; cd06257; DnaJ; 1.
DR CDD; cd14563; PTP_auxilin_N; 1.
DR Gene3D; 2.60.40.1110; -; 1.
DR Gene3D; 1.10.287.110; DnaJ domain; 1.
DR Gene3D; 3.90.190.10; Protein tyrosine phosphatase superfamily; 1.
DR InterPro; IPR035892; C2_domain_sf.
DR InterPro; IPR001623; DnaJ_domain.
DR InterPro; IPR036869; J_dom_sf.
DR InterPro; IPR029021; Prot-tyrosine_phosphatase-like.
DR InterPro; IPR014020; Tensin_C2-dom.
DR InterPro; IPR029023; Tensin_phosphatase.
DR InterPro; IPR000387; Tyr_Pase_dom.
DR PANTHER; PTHR23172; AUXILIN/CYCLIN G-ASSOCIATED KINASE-RELATED; 1.
DR PANTHER; PTHR23172:SF4; TYROSINE-PROTEIN PHOSPHATASE AUXILIN-RELATED; 1.
DR Pfam; PF10409; PTEN_C2; 1.
DR SMART; SM00271; DnaJ; 1.
DR SMART; SM01326; PTEN_C2; 1.
DR SUPFAM; SSF52799; (Phosphotyrosine protein) phosphatases II; 1.
DR SUPFAM; SSF49562; C2 domain (Calcium/lipid-binding domain, CaLB); 1.
DR SUPFAM; SSF46565; Chaperone J-domain; 1.
DR PROSITE; PS51182; C2_TENSIN; 1.
DR PROSITE; PS50076; DNAJ_2; 1.
DR PROSITE; PS51181; PPASE_TENSIN; 1.
DR PROSITE; PS50056; TYR_PHOSPHATASE_2; 1.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000011712}.
FT DOMAIN 86..253
FT /note="Phosphatase tensin-type"
FT /evidence="ECO:0000259|PROSITE:PS51181"
FT DOMAIN 170..241
FT /note="Tyrosine specific protein phosphatases"
FT /evidence="ECO:0000259|PROSITE:PS50056"
FT DOMAIN 259..397
FT /note="C2 tensin-type"
FT /evidence="ECO:0000259|PROSITE:PS51182"
FT DOMAIN 880..944
FT /note="J"
FT /evidence="ECO:0000259|PROSITE:PS50076"
FT REGION 481..531
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 539..558
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 563..806
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 486..502
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 582..605
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 625..663
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 681..727
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 756..791
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 944 AA; 103421 MW; C56C1FA9281F8A48 CRC64;
MGATEKGGKK SRRLFSSLRP WKATRRLWRT RSAPKAAQGA SSPDMEPSYG GGLFDMVKGG
AGRLFSNLKD NLKDTLKDTS SRVIQSVTSY TKGDLDFTYV TSRIIVMSFP LDNVDIGFRN
QVDDIRSFLD SRHLDHYTVY NLSPKSYRTA KFHSRVSECS WPIRQAPSLH NLFAVCRNMY
NWLLQNPKNV CVVHCLDGRA ASSILVGAMF IFCNLYSTPG PAVRLLYAKR PGIGLSPSHR
RYLGYMCDLL ADKPYRPHFK PLTIKSITVS PVPFFNKQRN GCRPYCDVLI GETKIYTTCA
DFERMKEYRV QDGKIFIPLS ITVQGDVVVS MYHLRSTIGS RLQAKVTNTQ IFQLQFHTGF
IPLETTVLKF TKPELDACDV PEKYPQLFQV TLDIELQPHD KVIDLTPPWE HYCTKDVNPS
ILFSSHQEHQ ETLVLGGQAP IDIPPDNPRH FGQGGFFSSL CWQDQKSEKS FCEEDHAALV
NPESEQSDDE LLTLSSPHGN ASGDKQHGAK KPSKKQQEPA APPPPEDVDL LGLEGSAVSK
NFSPPVAPPT NSELLSDLFG GGGAAGAAQA GQSGVEDMFH PSGPASTQST PRRSAPSTSA
SPTLRVGEGA TFDPFGAPSK PSGQDLLGSF LTTSSASSDP FLQPTRSPSP TVHASSTPAV
NIQPDVSGGW DWHTKPGSFG MGSKSAATSP TGSSHGTPTH QNKPQTLDPF ADLGTLGSSS
FASKPTTPTG LGGGFAPLSS PQKASPQPMG GGWQQGGGYN WQQTQSKPQP SMPHSSPQNR
PNYNVSFSAV PGGQNERGKG SANLEGKQKA ADFEDLLSGQ GFNAHKDKKG PRTIAEMRKE
EMAKEMDPEK LKILEWIEGK ERNIRALLST MHTVLWAGET KWKPVGMADL VTPEQVKKVY
RKAVLVVHPD KATGQPYEQY AKMIFMELND AWSEFENQGQ KPLY
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