ID A0A337SFR3_FELCA Unreviewed; 786 AA.
AC A0A337SFR3;
DT 10-OCT-2018, integrated into UniProtKB/TrEMBL.
DT 11-DEC-2019, sequence version 2.
DT 27-MAR-2024, entry version 28.
DE RecName: Full=DNA helicase MCM8 {ECO:0000256|ARBA:ARBA00041084};
DE EC=3.6.4.12 {ECO:0000256|ARBA:ARBA00012551};
GN Name=MCM8 {ECO:0000313|Ensembl:ENSFCAP00000046915.2,
GN ECO:0000313|VGNC:VGNC:81119};
OS Felis catus (Cat) (Felis silvestris catus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Carnivora; Feliformia; Felidae; Felinae; Felis.
OX NCBI_TaxID=9685 {ECO:0000313|Ensembl:ENSFCAP00000046915.2, ECO:0000313|Proteomes:UP000011712};
RN [1] {ECO:0000313|Ensembl:ENSFCAP00000046915.2, ECO:0000313|Proteomes:UP000011712}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Abyssinian {ECO:0000313|Ensembl:ENSFCAP00000046915.2,
RC ECO:0000313|Proteomes:UP000011712};
RX PubMed=17975172; DOI=10.1101/gr.6380007;
RA Pontius J.U., Mullikin J.C., Smith D.R., Lindblad-Toh K., Gnerre S.,
RA Clamp M., Chang J., Stephens R., Neelam B., Volfovsky N., Schaffer A.A.,
RA Agarwala R., Narfstrom K., Murphy W.J., Giger U., Roca A.L., Antunes A.,
RA Menotti-Raymond M., Yuhki N., Pecon-Slattery J., Johnson W.E., Bourque G.,
RA Tesler G., O'Brien S.J.;
RT "Initial sequence and comparative analysis of the cat genome.";
RL Genome Res. 17:1675-1689(2007).
RN [2] {ECO:0000313|Ensembl:ENSFCAP00000046915.2, ECO:0000313|Proteomes:UP000011712}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Abyssinian {ECO:0000313|Ensembl:ENSFCAP00000046915.2,
RC ECO:0000313|Proteomes:UP000011712};
RA Hillier L.W., Warren W., Obrien S., Wilson R.K.;
RT "Sequence assembly of the Felis catus genome version 6.2.";
RL Submitted (SEP-2011) to the EMBL/GenBank/DDBJ databases.
RN [3] {ECO:0000313|Ensembl:ENSFCAP00000046915.2}
RP IDENTIFICATION.
RC STRAIN=breed Abyssinian {ECO:0000313|Ensembl:ENSFCAP00000046915.2};
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Chromosome {ECO:0000256|ARBA:ARBA00004286}.
CC Nucleus {ECO:0000256|ARBA:ARBA00004123}.
CC -!- SIMILARITY: Belongs to the MCM family. {ECO:0000256|ARBA:ARBA00008010,
CC ECO:0000256|RuleBase:RU004070}.
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DR EMBL; AANG04003379; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; A0A337SFR3; -.
DR Ensembl; ENSFCAT00000050861.2; ENSFCAP00000046915.2; ENSFCAG00000011524.6.
DR VGNC; VGNC:81119; MCM8.
DR GeneTree; ENSGT01090000260080; -.
DR Proteomes; UP000011712; Chromosome A3.
DR Bgee; ENSFCAG00000011524; Expressed in embryonic head and 10 other cell types or tissues.
DR GO; GO:0005694; C:chromosome; IEA:UniProtKB-SubCell.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR GO; GO:0004386; F:helicase activity; IEA:UniProtKB-KW.
DR GO; GO:0032508; P:DNA duplex unwinding; IEA:InterPro.
DR CDD; cd22247; MCM8_WHD; 1.
DR Gene3D; 2.20.28.10; -; 1.
DR Gene3D; 2.40.50.140; Nucleic acid-binding proteins; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR InterPro; IPR031327; MCM.
DR InterPro; IPR001208; MCM_dom.
DR InterPro; IPR041562; MCM_lid.
DR InterPro; IPR033762; MCM_OB.
DR InterPro; IPR012340; NA-bd_OB-fold.
DR InterPro; IPR027417; P-loop_NTPase.
DR PANTHER; PTHR11630:SF47; DNA HELICASE MCM8; 1.
DR PANTHER; PTHR11630; DNA REPLICATION LICENSING FACTOR MCM FAMILY MEMBER; 1.
DR Pfam; PF00493; MCM; 1.
DR Pfam; PF17855; MCM_lid; 1.
DR Pfam; PF17207; MCM_OB; 1.
DR PRINTS; PR01657; MCMFAMILY.
DR SMART; SM00350; MCM; 1.
DR SUPFAM; SSF50249; Nucleic acid-binding proteins; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR PROSITE; PS50051; MCM_2; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|RuleBase:RU004070};
KW Chromosome {ECO:0000256|ARBA:ARBA00022454};
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125, ECO:0000256|RuleBase:RU004070};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741,
KW ECO:0000256|RuleBase:RU004070};
KW Reference proteome {ECO:0000313|Proteomes:UP000011712}.
FT DOMAIN 411..555
FT /note="MCM"
FT /evidence="ECO:0000259|PROSITE:PS50051"
FT REGION 16..53
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 26..46
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 786 AA; 88174 MW; BA1BA2193CB42D5D CRC64;
MNGDYRGRGF GRGRFQSWKR GRGGGSFTGK WREREHRPDL NKTTRKHTSE QTSQSLLLQS
TLDQFIPYKG WKLYFSEVYS SSSPFIEKIQ AFENFFTRRI DLYDKDEIER KGSILVDFKE
LTKDDEMTKL VPTIANELRD TPEKTLACMG LAIHQVLTRD LERHAAELQA QEGLSRDGET
MVNVPHIHAR VYNYEPLTQL KNVRANYYGK YIALRGTVVR VSNIKPLCTK MAFLCAACGE
VQGFPLPDGK YNLPTKCPVP ICRGRSFTAL RSSPLTVTMD WQSIKIQELM SDDQREAGRI
PRTIECELVH DLVDSCVPGD TVTITGVVKV SNAEEGSRNK NDKCMFLLYI EANSVSNSKG
QKTKTSEDGC KHGALMEFSL KDLYAIQEIQ AEENLFKLIV NSLCPVIFGH EAVCNVAPRG
VYVCGNTTTT SGLTVTLSKD SCSGDFALEA GALVLGDQGI CGIDEFDKMG NQHQALLEAM
EQQSISLAKA GMVCSLPART SIVAAANPVG GHYNKAKTVS ENLKMGSALL SRFDLVFILL
DTPNEDHDHL LSEHVIAIRA GKQRTVSGAT VTRMNSQDSN TSVLEAVSDK PLSERLKVVP
GEKIDLIPHQ LLRKYIGYAR QYVYPRLSTE AAQILQDFYL ELRKQSQRLN SSPITTRQLE
SLIRLTEARA RLELREEATK EDAEDIVEVM KYSMLGTYSD EFGNLDFERS QHGSGMSNRS
TAKRFISALN NIAERTYNNL FQFQQLRQIA KELNIQVADF ENFIGSLNDQ GYLLKKGPKV
YQLQTM
//
