ID A0A337SGK9_FELCA Unreviewed; 977 AA.
AC A0A337SGK9;
DT 10-OCT-2018, integrated into UniProtKB/TrEMBL.
DT 11-DEC-2019, sequence version 2.
DT 24-JAN-2024, entry version 24.
DE SubName: Full=NLR family pyrin domain containing 12 {ECO:0000313|Ensembl:ENSFCAP00000045065.2};
GN Name=NLRP12 {ECO:0000313|Ensembl:ENSFCAP00000045065.2,
GN ECO:0000313|VGNC:VGNC:97530};
OS Felis catus (Cat) (Felis silvestris catus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Carnivora; Feliformia; Felidae; Felinae; Felis.
OX NCBI_TaxID=9685 {ECO:0000313|Ensembl:ENSFCAP00000045065.2, ECO:0000313|Proteomes:UP000011712};
RN [1] {ECO:0000313|Ensembl:ENSFCAP00000045065.2, ECO:0000313|Proteomes:UP000011712}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Abyssinian {ECO:0000313|Ensembl:ENSFCAP00000045065.2,
RC ECO:0000313|Proteomes:UP000011712};
RX PubMed=17975172; DOI=10.1101/gr.6380007;
RA Pontius J.U., Mullikin J.C., Smith D.R., Lindblad-Toh K., Gnerre S.,
RA Clamp M., Chang J., Stephens R., Neelam B., Volfovsky N., Schaffer A.A.,
RA Agarwala R., Narfstrom K., Murphy W.J., Giger U., Roca A.L., Antunes A.,
RA Menotti-Raymond M., Yuhki N., Pecon-Slattery J., Johnson W.E., Bourque G.,
RA Tesler G., O'Brien S.J.;
RT "Initial sequence and comparative analysis of the cat genome.";
RL Genome Res. 17:1675-1689(2007).
RN [2] {ECO:0000313|Ensembl:ENSFCAP00000045065.2, ECO:0000313|Proteomes:UP000011712}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Abyssinian {ECO:0000313|Ensembl:ENSFCAP00000045065.2,
RC ECO:0000313|Proteomes:UP000011712};
RA Hillier L.W., Warren W., Obrien S., Wilson R.K.;
RT "Sequence assembly of the Felis catus genome version 6.2.";
RL Submitted (SEP-2011) to the EMBL/GenBank/DDBJ databases.
RN [3] {ECO:0000313|Ensembl:ENSFCAP00000045065.2}
RP IDENTIFICATION.
RC STRAIN=breed Abyssinian {ECO:0000313|Ensembl:ENSFCAP00000045065.2};
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the NLRP family.
CC {ECO:0000256|ARBA:ARBA00008665}.
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DR EMBL; AANG04003316; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; A0A337SGK9; -.
DR Ensembl; ENSFCAT00000066533.2; ENSFCAP00000045065.2; ENSFCAG00000014978.6.
DR VGNC; VGNC:97530; NLRP12.
DR GeneTree; ENSGT00940000160873; -.
DR Proteomes; UP000011712; Chromosome E2.
DR CDD; cd00116; LRR_RI; 1.
DR CDD; cd08320; Pyrin_NALPs; 1.
DR Gene3D; 1.10.533.10; Death Domain, Fas; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR Gene3D; 3.80.10.10; Ribonuclease Inhibitor; 1.
DR InterPro; IPR004020; DAPIN.
DR InterPro; IPR011029; DEATH-like_dom_sf.
DR InterPro; IPR001611; Leu-rich_rpt.
DR InterPro; IPR032675; LRR_dom_sf.
DR InterPro; IPR029495; NACHT-assoc.
DR InterPro; IPR007111; NACHT_NTPase.
DR InterPro; IPR041267; NLRP_HD2.
DR InterPro; IPR041075; NOD2_WH.
DR InterPro; IPR027417; P-loop_NTPase.
DR PANTHER; PTHR45690; NACHT, LRR AND PYD DOMAINS-CONTAINING PROTEIN 12; 1.
DR PANTHER; PTHR45690:SF11; NACHT, LRR AND PYD DOMAINS-CONTAINING PROTEIN 12; 1.
DR Pfam; PF14484; FISNA; 1.
DR Pfam; PF13516; LRR_6; 5.
DR Pfam; PF05729; NACHT; 1.
DR Pfam; PF17776; NLRC4_HD2; 1.
DR Pfam; PF17779; NOD2_WH; 1.
DR Pfam; PF02758; PYRIN; 1.
DR SMART; SM01288; FISNA; 1.
DR SMART; SM00368; LRR_RI; 9.
DR SMART; SM01289; PYRIN; 1.
DR SUPFAM; SSF47986; DEATH domain; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR SUPFAM; SSF52047; RNI-like; 1.
DR PROSITE; PS50824; DAPIN; 1.
DR PROSITE; PS50837; NACHT; 1.
PE 3: Inferred from homology;
KW Leucine-rich repeat {ECO:0000256|ARBA:ARBA00022614};
KW Reference proteome {ECO:0000313|Proteomes:UP000011712}.
FT DOMAIN 1..95
FT /note="Pyrin"
FT /evidence="ECO:0000259|PROSITE:PS50824"
FT DOMAIN 184..501
FT /note="NACHT"
FT /evidence="ECO:0000259|PROSITE:PS50837"
SQ SEQUENCE 977 AA; 109912 MW; FED14CFE233E8B6D CRC64;
MPRAPLSDSL CRLSAYLEEL EAVELKKFKL YLGALPEAEG GRIPWGKLEP AGPLDTAQLL
VAHCGPAAAW PLALGLFQRI HRRDLWERGQ REDPVRDPRE TYKDYVRRKF RLMQDRNARL
GECVNLSRRY TRLLLVKEHS TPMWAQQKLL DTGWGQARAV GHQASLIQME TLFEPDEERP
EPPRTVVLQG AAGMGKSMLA HKVMLDWADG KLFQGRFDYL FYINCREMNQ STSEQSARDL
ISSCWPEPSV PLQELVRVPE RLLFIIDGFD ELKPSFHHPQ GPWCLCWEEK RPTELLLGSL
LGKKLLPELS MIITTRPTAL DKLQRLLEHP RHVEILGFSE AERREYCYKY FHNAEQAAQV
FSFMRDNEPL FTLCFVPMVC WVVCTCLKQQ LEDGGLLRQT SRTTTAVYLL YLLSLMQPKP
GSPTLHPPAN QRALCSLAAD GVWHQKILFE EQDLRKHGLD GADVSSFLNM NIFQKDINCE
KFYSFIHLSF QEFFAAMYYI LGAGETGSSP EQSVTRLLAE YGFSGRSFLG LTVRFLFGLL
NEETRSYLEK SLCWEVSPHV KLELLAWIQS KARSEGSTLQ QGSLELFSCL YEIQEEEFIQ
QALSHFRVLV VGNITTKMEH VIASLCVKNC RNALTVRLHG AAYSPEEHDG GKWTSGPQAL
PAQSPETNVL PDAYSKQLAA ALSTNPHLRE LLLDHNALGS RGVRLLCEGL RHPSCKLQNL
RLKRCCVAPS ACRDLAAALM ANQNLRRMDL SGNGLGLPGV KMLCQGLRHP RCRLQAIQLR
KCELEAGACQ EIASVLSTNQ HLVELDLAGN SLEDLGLRLL CQGLRHPVCG LRILWLKICD
LTAAACEDLT SILSVNCSLR ELDLSLNDLG DPGVLLLCEG LRHPQCRLQT LRLDSCGLTA
KACEHLASAL GVSQTLTELY LTNNALGDTG VRLLCKGLSH PGCKLRVLWL FGMDLNKMTH
RRLDVLRGTR PHLDIGC
//
