ID A0A337SIK2_FELCA Unreviewed; 1517 AA.
AC A0A337SIK2;
DT 10-OCT-2018, integrated into UniProtKB/TrEMBL.
DT 10-OCT-2018, sequence version 1.
DT 27-MAR-2024, entry version 25.
DE SubName: Full=Eukaryotic translation initiation factor 4 gamma 1 {ECO:0000313|Ensembl:ENSFCAP00000045783.1};
GN Name=EIF4G1 {ECO:0000313|Ensembl:ENSFCAP00000045783.1,
GN ECO:0000313|VGNC:VGNC:97415};
OS Felis catus (Cat) (Felis silvestris catus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Carnivora; Feliformia; Felidae; Felinae; Felis.
OX NCBI_TaxID=9685 {ECO:0000313|Ensembl:ENSFCAP00000045783.1, ECO:0000313|Proteomes:UP000011712};
RN [1] {ECO:0000313|Ensembl:ENSFCAP00000045783.1, ECO:0000313|Proteomes:UP000011712}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Abyssinian {ECO:0000313|Ensembl:ENSFCAP00000045783.1,
RC ECO:0000313|Proteomes:UP000011712};
RX PubMed=17975172; DOI=10.1101/gr.6380007;
RA Pontius J.U., Mullikin J.C., Smith D.R., Lindblad-Toh K., Gnerre S.,
RA Clamp M., Chang J., Stephens R., Neelam B., Volfovsky N., Schaffer A.A.,
RA Agarwala R., Narfstrom K., Murphy W.J., Giger U., Roca A.L., Antunes A.,
RA Menotti-Raymond M., Yuhki N., Pecon-Slattery J., Johnson W.E., Bourque G.,
RA Tesler G., O'Brien S.J.;
RT "Initial sequence and comparative analysis of the cat genome.";
RL Genome Res. 17:1675-1689(2007).
RN [2] {ECO:0000313|Ensembl:ENSFCAP00000045783.1, ECO:0000313|Proteomes:UP000011712}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Abyssinian {ECO:0000313|Ensembl:ENSFCAP00000045783.1,
RC ECO:0000313|Proteomes:UP000011712};
RA Hillier L.W., Warren W., Obrien S., Wilson R.K.;
RT "Sequence assembly of the Felis catus genome version 6.2.";
RL Submitted (SEP-2011) to the EMBL/GenBank/DDBJ databases.
RN [3] {ECO:0000313|Ensembl:ENSFCAP00000045783.1}
RP IDENTIFICATION.
RC STRAIN=breed Abyssinian {ECO:0000313|Ensembl:ENSFCAP00000045783.1};
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the eukaryotic initiation factor 4G family.
CC {ECO:0000256|ARBA:ARBA00005775}.
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DR EMBL; AANG04001816; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR Ensembl; ENSFCAT00000060675.2; ENSFCAP00000045783.1; ENSFCAG00000007794.6.
DR VGNC; VGNC:97415; EIF4G1.
DR GeneTree; ENSGT00940000154648; -.
DR OMA; PRGGPNM; -.
DR Proteomes; UP000011712; Chromosome C2.
DR Bgee; ENSFCAG00000007794; Expressed in zone of skin and 10 other cell types or tissues.
DR GO; GO:0003723; F:RNA binding; IEA:InterPro.
DR GO; GO:0003743; F:translation initiation factor activity; IEA:UniProtKB-KW.
DR CDD; cd11559; W2_eIF4G1_like; 1.
DR Gene3D; 1.25.40.180; -; 3.
DR InterPro; IPR016024; ARM-type_fold.
DR InterPro; IPR045208; IF4G.
DR InterPro; IPR003891; Initiation_fac_eIF4g_MI.
DR InterPro; IPR003890; MIF4G-like_typ-3.
DR InterPro; IPR003307; W2_domain.
DR PANTHER; PTHR23253; EUKARYOTIC TRANSLATION INITIATION FACTOR 4 GAMMA; 1.
DR PANTHER; PTHR23253:SF10; EUKARYOTIC TRANSLATION INITIATION FACTOR 4 GAMMA 1; 1.
DR Pfam; PF02847; MA3; 1.
DR Pfam; PF02854; MIF4G; 1.
DR Pfam; PF02020; W2; 1.
DR SMART; SM00515; eIF5C; 1.
DR SMART; SM00544; MA3; 1.
DR SMART; SM00543; MIF4G; 1.
DR SUPFAM; SSF48371; ARM repeat; 3.
DR PROSITE; PS51366; MI; 1.
DR PROSITE; PS51363; W2; 1.
PE 3: Inferred from homology;
KW Reference proteome {ECO:0000313|Proteomes:UP000011712}.
FT DOMAIN 1158..1280
FT /note="MI"
FT /evidence="ECO:0000259|PROSITE:PS51366"
FT DOMAIN 1350..1516
FT /note="W2"
FT /evidence="ECO:0000259|PROSITE:PS51363"
FT REGION 79..197
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 212..233
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 278..414
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 419..438
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 453..518
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 587..631
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 648..674
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 942..1156
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 87..103
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 111..131
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 168..188
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 294..312
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 371..391
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 480..502
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 976..1004
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1029..1058
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1059..1140
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1517 AA; 167544 MW; B1636316B0745031 CRC64;
MMIPSQISYS ASQGAYYIPG QGRSTYVVPT QQYPVQPGAP SFYPGASPTE FGTYAGAYYP
AQGVQQFPTG VAPAPVLMNQ PPQIAPKRER KTIRIRDPNQ GGKDITEEIM SGARTASTPT
PPQTGGGLEP QANGETPQVA VVVRPDDRSQ GAVIGSRPGL PGPEHSPSES QPSSPCPTPS
PPPILEPGSE PNLAVLSIPG DTVTTGMIQM SVEESTPMPR ETREPYCLSP EPTPLAEPIL
EVEVTLSKPI PESEFSSSPL QVPTPLASHK VEILPEPNGM VSSEDLEPEV ESSPEIAPLP
PPACPSESPV PIAPTAQPEE LLNGAPSPPA VDLSPVSEPQ EQAKEVTASV APPAVLSATP
AMAPPAASPA QEEEMEEEEE DEEEGETGDA EGEKGGEELL PQESTPVAAH LPQNLEAAAA
TQVAVSVPKR RRKIKELNKK EAVGDLLDAF KEVSPGVPEV ENQPPVGTSP GLEPEGSSVP
PRPEEADETW DSKEDKIHNA ENIQPGEQKY EYKSDQWKPL NLEEKKRYDR EFLLGFQFIF
ASMQKPEGLP HISDVVLDKA NKTPLRPLDP ARLQGINCGP DFTPSFANLG RPALSNRGPP
RGGPGGELPR GPQAGLGPRR SQQGPRKEPR KIIATVLMTE DIKLNKAEKA WKPSSKRTAA
DKDRGEEDAD GSKTQDLFRR VRSILNKLTP QMFQQLMKQV TQLAIDTEER LKGVIDLIFE
KAISEPNFSV AYANMCRCLM ALKVPTTEKP TVTVNFRKLL LNRCQKEFEK DKDDDEVFEK
KQKEMDEAAT AEERGRLKEE LEEARDIARR RSLGNIKFIG ELFKLKMLTE AIMHDCVVKL
LKNHDEESLE CLCRLLTTIG KDLDFEKAKP RMDQYFNQME KIIKEKKTSS RIRFMLQDVL
DLRRSNWVPR RGDQGPKTID QIHKEAEMEE HWEHVKVQQL MAKGSDKRRG GPPGPPISRG
LPLVDDGGWN TVPISKGSRP IDTSRLTKIT KPGSIDSNNQ LFAPGGRLSW GKGSSGGSGA
KPSDAASEAA RPATSTLNRF SALQQAVPTE NTDSRRVVQR SSLSRERGEK AGDRGDRLER
SERGSERGDR LDRSRTPATK RSFSKEVEER SRERPSQPEG LRKAASLTED RDRGRDAVKR
EATLPPVSPP KAALSEEELE KKSKAIIEEY LHLNDMKEAV QCVQELASPS LLFIFVRHGI
ESTLERSTIA REHMGRLLHQ LLFAGHLSTA QYYQGLYEIL ELAEDMEIDI PHVWLYLAEL
ITPILQEGGV PMGELFREIT KPLRPMGKAA SLLLEILGLL CKSMGPKKVG MLWREAGLSW
KEFLPEGQDV SAFVAEQKVE YTLGEESEAP GQRMLSSEEL SKQLEKLLKE GSSNQRVFDW
IEANLSEQQV ASNTLVRALM TAVCYSAIIF ETPLRVDVAV LKARAKLLQK YLCDEQKELQ
ALYALQALVV TLEQPANLLR MFFDALYDED VVKEDAFYSW ESSKDPAEQQ GKGVALKSVT
AFFKWLREAE EEESDHN
//
