ID A0A337SKD6_FELCA Unreviewed; 857 AA.
AC A0A337SKD6;
DT 10-OCT-2018, integrated into UniProtKB/TrEMBL.
DT 11-DEC-2019, sequence version 2.
DT 24-JAN-2024, entry version 25.
DE SubName: Full=Host cell factor C2 {ECO:0000313|Ensembl:ENSFCAP00000048332.2};
GN Name=HCFC2 {ECO:0000313|Ensembl:ENSFCAP00000048332.2,
GN ECO:0000313|VGNC:VGNC:62765};
OS Felis catus (Cat) (Felis silvestris catus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Carnivora; Feliformia; Felidae; Felinae; Felis.
OX NCBI_TaxID=9685 {ECO:0000313|Ensembl:ENSFCAP00000048332.2, ECO:0000313|Proteomes:UP000011712};
RN [1] {ECO:0000313|Ensembl:ENSFCAP00000048332.2, ECO:0000313|Proteomes:UP000011712}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Abyssinian {ECO:0000313|Ensembl:ENSFCAP00000048332.2,
RC ECO:0000313|Proteomes:UP000011712};
RX PubMed=17975172; DOI=10.1101/gr.6380007;
RA Pontius J.U., Mullikin J.C., Smith D.R., Lindblad-Toh K., Gnerre S.,
RA Clamp M., Chang J., Stephens R., Neelam B., Volfovsky N., Schaffer A.A.,
RA Agarwala R., Narfstrom K., Murphy W.J., Giger U., Roca A.L., Antunes A.,
RA Menotti-Raymond M., Yuhki N., Pecon-Slattery J., Johnson W.E., Bourque G.,
RA Tesler G., O'Brien S.J.;
RT "Initial sequence and comparative analysis of the cat genome.";
RL Genome Res. 17:1675-1689(2007).
RN [2] {ECO:0000313|Ensembl:ENSFCAP00000048332.2, ECO:0000313|Proteomes:UP000011712}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Abyssinian {ECO:0000313|Ensembl:ENSFCAP00000048332.2,
RC ECO:0000313|Proteomes:UP000011712};
RA Hillier L.W., Warren W., Obrien S., Wilson R.K.;
RT "Sequence assembly of the Felis catus genome version 6.2.";
RL Submitted (SEP-2011) to the EMBL/GenBank/DDBJ databases.
RN [3] {ECO:0000313|Ensembl:ENSFCAP00000048332.2}
RP IDENTIFICATION.
RC STRAIN=breed Abyssinian {ECO:0000313|Ensembl:ENSFCAP00000048332.2};
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
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DR EMBL; AANG04003655; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; A0A337SKD6; -.
DR STRING; 9685.ENSFCAP00000048332; -.
DR Ensembl; ENSFCAT00000062578.2; ENSFCAP00000048332.2; ENSFCAG00000014081.6.
DR VGNC; VGNC:62765; HCFC2.
DR GeneTree; ENSGT00940000160733; -.
DR InParanoid; A0A337SKD6; -.
DR OMA; GWIPVPE; -.
DR Proteomes; UP000011712; Chromosome B4.
DR Bgee; ENSFCAG00000014081; Expressed in liver and 10 other cell types or tissues.
DR GO; GO:0005829; C:cytosol; IEA:Ensembl.
DR GO; GO:0035097; C:histone methyltransferase complex; IBA:GO_Central.
DR GO; GO:0071339; C:MLL1 complex; IEA:Ensembl.
DR GO; GO:0016604; C:nuclear body; IEA:Ensembl.
DR GO; GO:0005886; C:plasma membrane; IEA:Ensembl.
DR GO; GO:0048188; C:Set1C/COMPASS complex; IEA:Ensembl.
DR GO; GO:0003713; F:transcription coactivator activity; IBA:GO_Central.
DR GO; GO:0140374; P:antiviral innate immune response; IEA:Ensembl.
DR GO; GO:0006338; P:chromatin remodeling; IBA:GO_Central.
DR GO; GO:1902615; P:immune response involved in response to exogenous dsRNA; IEA:Ensembl.
DR GO; GO:0006355; P:regulation of DNA-templated transcription; IBA:GO_Central.
DR GO; GO:0034139; P:regulation of toll-like receptor 3 signaling pathway; IEA:Ensembl.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IEA:Ensembl.
DR CDD; cd00063; FN3; 2.
DR Gene3D; 6.10.250.2590; -; 1.
DR Gene3D; 2.60.40.10; Immunoglobulins; 2.
DR Gene3D; 2.120.10.80; Kelch-type beta propeller; 2.
DR InterPro; IPR003961; FN3_dom.
DR InterPro; IPR036116; FN3_sf.
DR InterPro; IPR011043; Gal_Oxase/kelch_b-propeller.
DR InterPro; IPR043536; HCF1/2.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR015915; Kelch-typ_b-propeller.
DR InterPro; IPR006652; Kelch_1.
DR PANTHER; PTHR46003; HOST CELL FACTOR; 1.
DR PANTHER; PTHR46003:SF2; HOST CELL FACTOR 2; 1.
DR Pfam; PF01344; Kelch_1; 1.
DR Pfam; PF13415; Kelch_3; 1.
DR Pfam; PF13854; Kelch_5; 2.
DR SMART; SM00060; FN3; 1.
DR SUPFAM; SSF49265; Fibronectin type III; 1.
DR SUPFAM; SSF50965; Galactose oxidase, central domain; 1.
DR SUPFAM; SSF117281; Kelch motif; 1.
DR PROSITE; PS50853; FN3; 1.
PE 4: Predicted;
KW Kelch repeat {ECO:0000256|ARBA:ARBA00022441};
KW Reference proteome {ECO:0000313|Proteomes:UP000011712};
KW Repeat {ECO:0000256|ARBA:ARBA00022737}.
FT DOMAIN 583..675
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT REGION 413..453
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 420..445
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 857 AA; 93892 MW; DB723E9D0A468FA0 CRC64;
MAAPSLLNWR RVSSFTGPVP RARHGHRAVA IRELMIIFGG GNEGIADELH VYNTVTNQWF
LPAVRGDIPP GCAAHGFVCD GTRILVFGGM VEYGRYSNEL YELQASRWLW KKVKPHPPSS
GLPPCPRLGH SFSLYGNKCY LFGGLANESE DSNNNVPRYL NDFYELELQH GSGVVGWSIP
VTKGIVPSPR ESHTAVIYCK KDSGSPKMYV FGGMCGARLD DLWQLDLETM SWSKPETKGT
VPLPRSLHTA SVIGNKMYIF GGWVPHKGEN IETSPHDCEW RCTSSFSYLN LDTAEWTTLV
SDSQEDKKNS RPRPRAGHCA VAIGTRLYFW SGRDGYKKAL NSQVCCKDLW YLDTEKPPAP
SQVQLIKATT NSFHVKWDEV PTVEGYLLQL NTDLPHQTAS SDSSLAPNLQ GVRMDPHRPG
SNSTVPNSIS DTTNSAKTEH TPMKGTSVKN RPDLKASTDF NAALHPSMAT NTSNHNSCVV
DMLRKNEGPH TSANIGVLSS CLDLRTVIPE TSVSSSVSSA QTMVTQQTIK TESSSTNGAV
VKDETSLTTF STKSEVDDTC ALPATKISRV ETQATAMSFS KETPSNPVAT VKAGERQWCD
VGIFKNNTAL VSQFYLLPKG KQSISKIGNA DVPDYSLLKK QDLVPGTGYR FRVAAINGCG
IGPFSKISEF KTCIPGFPGA PSAVRISKVL PLFREEKICF QNVEGIHLSW EPPTSPSGNI
LEYSAYLAIR TAQIQDNPSQ LVFMRIYCGL KTSCIVTAGQ LANAHIDYTS RPAIVFRISA
KNEKGYGPAT QVRWLQGISR FCCRYKSGVN IQSNVTAEKM VQTKSRNNCR GPGLSVSTMR
PYARSGGLSS CVLELHV
//
