ID A0A337SKM2_FELCA Unreviewed; 1254 AA.
AC A0A337SKM2;
DT 10-OCT-2018, integrated into UniProtKB/TrEMBL.
DT 11-DEC-2019, sequence version 2.
DT 27-MAR-2024, entry version 29.
DE SubName: Full=Protocadherin 7 {ECO:0000313|Ensembl:ENSFCAP00000046556.2};
GN Name=PCDH7 {ECO:0000313|Ensembl:ENSFCAP00000046556.2,
GN ECO:0000313|VGNC:VGNC:68717};
OS Felis catus (Cat) (Felis silvestris catus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Carnivora; Feliformia; Felidae; Felinae; Felis.
OX NCBI_TaxID=9685 {ECO:0000313|Ensembl:ENSFCAP00000046556.2, ECO:0000313|Proteomes:UP000011712};
RN [1] {ECO:0000313|Ensembl:ENSFCAP00000046556.2, ECO:0000313|Proteomes:UP000011712}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Abyssinian {ECO:0000313|Ensembl:ENSFCAP00000046556.2,
RC ECO:0000313|Proteomes:UP000011712};
RX PubMed=17975172; DOI=10.1101/gr.6380007;
RA Pontius J.U., Mullikin J.C., Smith D.R., Lindblad-Toh K., Gnerre S.,
RA Clamp M., Chang J., Stephens R., Neelam B., Volfovsky N., Schaffer A.A.,
RA Agarwala R., Narfstrom K., Murphy W.J., Giger U., Roca A.L., Antunes A.,
RA Menotti-Raymond M., Yuhki N., Pecon-Slattery J., Johnson W.E., Bourque G.,
RA Tesler G., O'Brien S.J.;
RT "Initial sequence and comparative analysis of the cat genome.";
RL Genome Res. 17:1675-1689(2007).
RN [2] {ECO:0000313|Ensembl:ENSFCAP00000046556.2, ECO:0000313|Proteomes:UP000011712}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Abyssinian {ECO:0000313|Ensembl:ENSFCAP00000046556.2,
RC ECO:0000313|Proteomes:UP000011712};
RA Hillier L.W., Warren W., Obrien S., Wilson R.K.;
RT "Sequence assembly of the Felis catus genome version 6.2.";
RL Submitted (SEP-2011) to the EMBL/GenBank/DDBJ databases.
RN [3] {ECO:0000313|Ensembl:ENSFCAP00000046556.2}
RP IDENTIFICATION.
RC STRAIN=breed Abyssinian {ECO:0000313|Ensembl:ENSFCAP00000046556.2};
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
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DR EMBL; AANG04001605; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; A0A337SKM2; -.
DR STRING; 9685.ENSFCAP00000046556; -.
DR Ensembl; ENSFCAT00000057410.2; ENSFCAP00000046556.2; ENSFCAG00000014975.6.
DR VGNC; VGNC:68717; PCDH7.
DR GeneTree; ENSGT00940000157221; -.
DR InParanoid; A0A337SKM2; -.
DR OMA; AFDREHQ; -.
DR Proteomes; UP000011712; Chromosome B1.
DR Bgee; ENSFCAG00000014975; Expressed in brain and 10 other cell types or tissues.
DR GO; GO:0005886; C:plasma membrane; IEA:InterPro.
DR GO; GO:0005509; F:calcium ion binding; IEA:UniProtKB-UniRule.
DR GO; GO:0007155; P:cell adhesion; IBA:GO_Central.
DR GO; GO:0007156; P:homophilic cell adhesion via plasma membrane adhesion molecules; IEA:InterPro.
DR CDD; cd11304; Cadherin_repeat; 7.
DR Gene3D; 2.60.40.60; Cadherins; 8.
DR InterPro; IPR002126; Cadherin-like_dom.
DR InterPro; IPR015919; Cadherin-like_sf.
DR InterPro; IPR020894; Cadherin_CS.
DR InterPro; IPR013164; Cadherin_N.
DR InterPro; IPR013585; Protocadherin.
DR PANTHER; PTHR24028; CADHERIN-87A; 1.
DR PANTHER; PTHR24028:SF253; PROTOCADHERIN-7; 1.
DR Pfam; PF00028; Cadherin; 6.
DR Pfam; PF08266; Cadherin_2; 1.
DR Pfam; PF08374; Protocadherin; 1.
DR PRINTS; PR00205; CADHERIN.
DR SMART; SM00112; CA; 7.
DR SUPFAM; SSF49313; Cadherin-like; 7.
DR PROSITE; PS00232; CADHERIN_1; 4.
DR PROSITE; PS50268; CADHERIN_2; 7.
PE 4: Predicted;
KW Calcium {ECO:0000256|ARBA:ARBA00022837, ECO:0000256|PROSITE-
KW ProRule:PRU00043}; Cell adhesion {ECO:0000256|ARBA:ARBA00022889};
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Membrane {ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000011712};
KW Repeat {ECO:0000256|ARBA:ARBA00022737}; Signal {ECO:0000256|SAM:SignalP};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT SIGNAL 1..30
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 31..1254
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5023899972"
FT TRANSMEM 884..907
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 52..143
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 144..314
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 315..421
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 438..541
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 542..645
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 646..748
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 759..868
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT REGION 182..248
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 916..998
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1094..1136
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1219..1243
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 916..937
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 951..985
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1094..1127
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1254 AA; 136074 MW; E29E261CCE28C26C CRC64;
MLRMRTAGWA RGWCLGCCLL LPLSLSLAAA KQLLRYRLAE EGPADVRIGN VASDLGIVTG
SGEVTFSLES GSEYLKIDNL TGELSTSERR IDREKLPQCQ MIFDENECFL DFEVSVIGPS
QSWVDLFEGR VIVLDINDNT PTFPSPVLTL TVEENRPVGT LYLLPTATDR DFGRNGIERY
ELLQEPGGGG GGGGGGGGGE GRRAGPADSA PYPGGGGNGA SGGGPGGSKR RPDAPEGGGG
TNPGGRSSVF ELQVADTPDG EKQPQLIVKG ALDREQRDSY ELTLRVRDGG DPPRSSQAIL
RVLITDVNDN SPRFEKSVYE ADLAENSAPG TPILQLRAAD LDVGVNGQIE YVFGAATESV
RRLLRLDETS GWLSVLHRID REEVNQLRFT VMARDRGQPP KTDKATVVLN IKDENDNVPS
IEIRKIGRIP LKDGVANVAE DVLVDTPIAL VQVSDRDQGE NGVVTCTVVG DVPFQLKPAS
DTEGDQNKKK YFLHTSAPLD YETTREFNVV IVAVDSGSPS LSSNNSLVVK VGDTNDNPPV
FGQSVVEVYF PENNIPGERV ATVLATDADS GKNAEIAYSL DSSVMGIFAI DPDSGDILVN
TVLDREQTDR YEFKVNAKDK GIPVLQGSTT VIVQVADKND NDPKFMQDVF TFYVKENLQP
NSPVGMVTVM DADKGRNAEM SLYIEENSNI FSIENDTGTI YSTMSFDREH QTTYTFRVKA
VDGGDPPRSA TATVSLFVMD ENDNAPTVTL PRNISYTLLP PSSNVRTVVA TVLATDSDDG
INADLNYSIV GGNPFKLFEI DSTSGVVSLV GKLTQKHYGL HRLVVQVNDS GQPSQSTTTL
VHVFVNESVS NATVIDSQIA RSLHTPLTQD IAGDPSYEIS KQRLSIVIGV VAGIMTVILI
ILIVVMARYC RSKSKNGYEA GKKDHEDFFT PQQHDKSKKP KKDKKNKKSK QPLYSSIVTV
EASKPNGQRY DSVNEKLSDS PNMGRYRSVN GGPGSPDLAR HYKSSSPLPT VQLHPQSPTA
GKKHQAVQDL PPANTFVGAG DNISIGSDHC SEYSCQTNNK YSKQVDTVQT TNPPGHIEES
CKMNPFRRVT FSVVSQPQDP HQGSLQSCYD SGLEESETPS SAAPFQGTAD SRPLPDVALT
GKCTRECDEY GHSDSCWMPV RTSPERKKSQ PKLSTFMPVD ERGSQEKLAN GEAAIMGDRN
RNLLNKKLTS SYETFSAASF SKNEEANPED IPLTKTGEYK PSPVNTLTRR EVYL
//
