ID A0A337SKY7_FELCA Unreviewed; 959 AA.
AC A0A337SKY7;
DT 10-OCT-2018, integrated into UniProtKB/TrEMBL.
DT 10-OCT-2018, sequence version 1.
DT 27-MAR-2024, entry version 27.
DE RecName: Full=Oxysterol-binding protein {ECO:0000256|RuleBase:RU003845};
GN Name=OSBPL6 {ECO:0000313|Ensembl:ENSFCAP00000047768.1,
GN ECO:0000313|VGNC:VGNC:63981};
OS Felis catus (Cat) (Felis silvestris catus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Carnivora; Feliformia; Felidae; Felinae; Felis.
OX NCBI_TaxID=9685 {ECO:0000313|Ensembl:ENSFCAP00000047768.1, ECO:0000313|Proteomes:UP000011712};
RN [1] {ECO:0000313|Ensembl:ENSFCAP00000047768.1, ECO:0000313|Proteomes:UP000011712}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Abyssinian {ECO:0000313|Ensembl:ENSFCAP00000047768.1,
RC ECO:0000313|Proteomes:UP000011712};
RX PubMed=17975172; DOI=10.1101/gr.6380007;
RA Pontius J.U., Mullikin J.C., Smith D.R., Lindblad-Toh K., Gnerre S.,
RA Clamp M., Chang J., Stephens R., Neelam B., Volfovsky N., Schaffer A.A.,
RA Agarwala R., Narfstrom K., Murphy W.J., Giger U., Roca A.L., Antunes A.,
RA Menotti-Raymond M., Yuhki N., Pecon-Slattery J., Johnson W.E., Bourque G.,
RA Tesler G., O'Brien S.J.;
RT "Initial sequence and comparative analysis of the cat genome.";
RL Genome Res. 17:1675-1689(2007).
RN [2] {ECO:0000313|Ensembl:ENSFCAP00000047768.1, ECO:0000313|Proteomes:UP000011712}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Abyssinian {ECO:0000313|Ensembl:ENSFCAP00000047768.1,
RC ECO:0000313|Proteomes:UP000011712};
RA Hillier L.W., Warren W., Obrien S., Wilson R.K.;
RT "Sequence assembly of the Felis catus genome version 6.2.";
RL Submitted (SEP-2011) to the EMBL/GenBank/DDBJ databases.
RN [3] {ECO:0000313|Ensembl:ENSFCAP00000047768.1}
RP IDENTIFICATION.
RC STRAIN=breed Abyssinian {ECO:0000313|Ensembl:ENSFCAP00000047768.1};
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the OSBP family.
CC {ECO:0000256|RuleBase:RU003844}.
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DR EMBL; AANG04001482; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR RefSeq; XP_019693862.1; XM_019838303.1.
DR AlphaFoldDB; A0A337SKY7; -.
DR PaxDb; 9685-ENSFCAP00000011634; -.
DR Ensembl; ENSFCAT00000063184.2; ENSFCAP00000047768.1; ENSFCAG00000012535.6.
DR VGNC; VGNC:63981; OSBPL6.
DR GeneTree; ENSGT00940000156791; -.
DR Proteomes; UP000011712; Chromosome C1.
DR Bgee; ENSFCAG00000012535; Expressed in brain and 10 other cell types or tissues.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR GO; GO:0008289; F:lipid binding; IEA:UniProtKB-KW.
DR GO; GO:0006869; P:lipid transport; IEA:UniProtKB-KW.
DR CDD; cd13287; PH_ORP3_ORP6_ORP7; 1.
DR Gene3D; 2.40.160.120; -; 1.
DR Gene3D; 3.30.70.3490; -; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR InterPro; IPR037239; OSBP_sf.
DR InterPro; IPR000648; Oxysterol-bd.
DR InterPro; IPR018494; Oxysterol-bd_CS.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR041680; PH_8.
DR InterPro; IPR001849; PH_domain.
DR PANTHER; PTHR10972; OXYSTEROL-BINDING PROTEIN-RELATED; 1.
DR PANTHER; PTHR10972:SF76; OXYSTEROL-BINDING PROTEIN-RELATED PROTEIN 6; 1.
DR Pfam; PF01237; Oxysterol_BP; 1.
DR Pfam; PF15409; PH_8; 1.
DR SMART; SM00233; PH; 1.
DR SUPFAM; SSF144000; Oxysterol-binding protein-like; 1.
DR SUPFAM; SSF50729; PH domain-like; 1.
DR PROSITE; PS01013; OSBP; 1.
DR PROSITE; PS50003; PH_DOMAIN; 1.
PE 3: Inferred from homology;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Lipid transport {ECO:0000256|ARBA:ARBA00023055,
KW ECO:0000256|RuleBase:RU003845};
KW Lipid-binding {ECO:0000256|ARBA:ARBA00023121};
KW Reference proteome {ECO:0000313|Proteomes:UP000011712};
KW Transport {ECO:0000256|ARBA:ARBA00022448, ECO:0000256|RuleBase:RU003845}.
FT DOMAIN 86..181
FT /note="PH"
FT /evidence="ECO:0000259|PROSITE:PS50003"
FT REGION 1..62
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 445..472
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 1..53
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 959 AA; 108819 MW; DDB7372BA4C91D04 CRC64;
MSSDEKGISP AHKTSTPTHR SASSSTPSHR DSRQSIHVLE RTASSSTEPS VSRQLLEPEP
VPLSKEADSW EIIEGLKIGQ TNVQRPDKHE GFMLKKRKWP LKGWHKRFFV LDNGMLKYSK
APLDIQKGKV HGSIDVGLSV MSIKKKARRI DLDTEEHIYH LKVKSQDWFD AWVSKLRHHR
LYRQNEIVRS PRDASFHIFP STSTAESSPA ANVSVVDGKV QANSFPWQSP LPCSNSLPAT
CTTGQSKVAA WLQDSEEMDR CAEDLAHCQS NLVELSKLLQ NLEILQRTQS APNFTDMQAN
CVDISKKDKR VTRRWRTKSV SKDTKIQLQE GPSAKGQFST TRRRQRLAAA VATTVPFSAT
MSPVRLHSSN PNLCADIEFQ TPPSHLTDPL ESSTDYTKLQ EEFCLIAQKV HSLLKSAFNS
IAIEKEKLKQ IVSEQDHNKG HSTQVARLRQ SLSQALNQNA ELRSRLNRIH SESIICDQVV
SVNIIPSPDE AGEQIHVSLP LSQQVANESR LSMSESVSEF FDAQEVLLSA SSSENEASDD
ESYISDVSDN ISEDNTSVAD NISRQILNGE LTGGAFRNGR RTCLPAPCPD TSNINLWNIL
RNNIGKDLSK VSMPVELNEP LNTLQHLCEE IEYSELLDKA SETDDPYERM VLIAAFAVSG
YCSTYFRAGS KPFNPVLGET YECIREDKGF RFFSEQVSHH PPISACHCES KNFVFWQDIR
WKNKFWGKSM EILPVGTLNV MLPRYGDCYV WNKVTTCIHN ILSGRRWIEH YGEVTIRNTK
SSVCICKLTF VKVNYWNSNV NEVQGVVMDQ EGKVVHRLFG KWHEGLFCGV APSAKCIWRP
GSMPTNYELY YGFTRFAIEL NELDPVLKDL LPPTDARFRP DQRFLEEGNL EAAAAEKQRV
EELQRSRRRY MEENNLEHIP KFFKKVIDAN QREAWVSNDT YWELRKDPGF SKVDSPVLW
//
