ID A0A337SLZ3_FELCA Unreviewed; 1303 AA.
AC A0A337SLZ3;
DT 10-OCT-2018, integrated into UniProtKB/TrEMBL.
DT 10-OCT-2018, sequence version 1.
DT 24-JAN-2024, entry version 23.
DE SubName: Full=Regulatory associated protein of MTOR complex 1 {ECO:0000313|Ensembl:ENSFCAP00000048214.1};
GN Name=RPTOR {ECO:0000313|Ensembl:ENSFCAP00000048214.1,
GN ECO:0000313|VGNC:VGNC:64763};
OS Felis catus (Cat) (Felis silvestris catus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Carnivora; Feliformia; Felidae; Felinae; Felis.
OX NCBI_TaxID=9685 {ECO:0000313|Ensembl:ENSFCAP00000048214.1, ECO:0000313|Proteomes:UP000011712};
RN [1] {ECO:0000313|Ensembl:ENSFCAP00000048214.1, ECO:0000313|Proteomes:UP000011712}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Abyssinian {ECO:0000313|Ensembl:ENSFCAP00000048214.1,
RC ECO:0000313|Proteomes:UP000011712};
RX PubMed=17975172; DOI=10.1101/gr.6380007;
RA Pontius J.U., Mullikin J.C., Smith D.R., Lindblad-Toh K., Gnerre S.,
RA Clamp M., Chang J., Stephens R., Neelam B., Volfovsky N., Schaffer A.A.,
RA Agarwala R., Narfstrom K., Murphy W.J., Giger U., Roca A.L., Antunes A.,
RA Menotti-Raymond M., Yuhki N., Pecon-Slattery J., Johnson W.E., Bourque G.,
RA Tesler G., O'Brien S.J.;
RT "Initial sequence and comparative analysis of the cat genome.";
RL Genome Res. 17:1675-1689(2007).
RN [2] {ECO:0000313|Ensembl:ENSFCAP00000048214.1, ECO:0000313|Proteomes:UP000011712}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Abyssinian {ECO:0000313|Ensembl:ENSFCAP00000048214.1,
RC ECO:0000313|Proteomes:UP000011712};
RA Hillier L.W., Warren W., Obrien S., Wilson R.K.;
RT "Sequence assembly of the Felis catus genome version 6.2.";
RL Submitted (SEP-2011) to the EMBL/GenBank/DDBJ databases.
RN [3] {ECO:0000313|Ensembl:ENSFCAP00000048214.1}
RP IDENTIFICATION.
RC STRAIN=breed Abyssinian {ECO:0000313|Ensembl:ENSFCAP00000048214.1};
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the WD repeat RAPTOR family.
CC {ECO:0000256|ARBA:ARBA00009257}.
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DR EMBL; AANG04004184; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR Ensembl; ENSFCAT00000063604.2; ENSFCAP00000048214.1; ENSFCAG00000011453.6.
DR VGNC; VGNC:64763; RPTOR.
DR GeneTree; ENSGT00640000091541; -.
DR Proteomes; UP000011712; Chromosome E1.
DR Bgee; ENSFCAG00000011453; Expressed in prefrontal cortex and 10 other cell types or tissues.
DR GO; GO:0031931; C:TORC1 complex; IEA:InterPro.
DR GO; GO:0031929; P:TOR signaling; IEA:InterPro.
DR Gene3D; 1.25.10.10; Leucine-rich Repeat Variant; 1.
DR Gene3D; 2.130.10.10; YVTN repeat-like/Quinoprotein amine dehydrogenase; 2.
DR InterPro; IPR011989; ARM-like.
DR InterPro; IPR016024; ARM-type_fold.
DR InterPro; IPR000357; HEAT.
DR InterPro; IPR004083; Raptor.
DR InterPro; IPR029347; Raptor_N.
DR InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR InterPro; IPR036322; WD40_repeat_dom_sf.
DR InterPro; IPR001680; WD40_rpt.
DR PANTHER; PTHR12848; REGULATORY-ASSOCIATED PROTEIN OF MTOR; 1.
DR PANTHER; PTHR12848:SF16; REGULATORY-ASSOCIATED PROTEIN OF MTOR; 1.
DR Pfam; PF02985; HEAT; 2.
DR Pfam; PF14538; Raptor_N; 1.
DR Pfam; PF00400; WD40; 1.
DR PRINTS; PR01547; YEAST176DUF.
DR SMART; SM01302; Raptor_N; 1.
DR SMART; SM00320; WD40; 7.
DR SUPFAM; SSF48371; ARM repeat; 1.
DR SUPFAM; SSF50978; WD40 repeat-like; 1.
PE 3: Inferred from homology;
KW Reference proteome {ECO:0000313|Proteomes:UP000011712};
KW Repeat {ECO:0000256|ARBA:ARBA00022737}; Signal {ECO:0000256|SAM:SignalP};
KW WD repeat {ECO:0000256|ARBA:ARBA00022574}.
FT SIGNAL 1..33
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 34..1303
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5016450373"
FT DOMAIN 22..175
FT /note="Raptor N-terminal CASPase-like"
FT /evidence="ECO:0000259|SMART:SM01302"
FT REGION 663..684
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 717..739
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 823..913
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 843..861
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 893..913
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1303 AA; 145123 MW; F31F3AC388A0DADC CRC64;
MFGSSLSSGG MPGCCCSRPI ALMKTVSVAL VLCLNVGVDP PDVVKTTPCA RLECWIDPLS
MGPQKALETI GANLQKQYEN WQPRARYKQS LDPTVDEVKK LCTSLRRNAK EERVLFHYNG
HGVPRPTVNG EIWVFNKNYT QYIPLSIYDL QTWMGSPSIF VYDCSNAGLI VKSFKQFALQ
REQELEVAAI NPNHPLAQMP LPPSMKNCIQ LAACEANELL PMIPDLPADL FTSCLTTPIK
IALRWFCMQK CVSLVPGVTL DLIEKIPGRL NDRRTPLGEL NWIFTAITDT IAWNVLPRDL
FQKLFRQDLL VASLFRNFLL AERIMRSYNC TPVSSPRLPP TYMHAMWQAW DLAVDICLSQ
LPTIIEEGTA FRHSPFFAEQ LTAFQVWLTM GVENRSPPEQ LPIVLQVLLS QVHRLRALDL
LGRFLDLGPW AVSLALSVGI FPYVLKLLQS SARELRPLLV FIWAKILAVD SSCQADLVKD
NGHKYFLSVL ADPYMPAEHR TMTAFILAVI VNSYNTGQEA CLQGNLIAIC LEQLNDPHPL
LRQWVAICLG RIWQNFDSAR WCGVRDSAHE KLYSLLSDPI PEVRCAAVFA LGTFVGNSAE
RTDHSTTIDH NVAMMLAQLI NDGSPVVRKE LVVALSHLVV QYESNFCTVA LQFMEEEKNY
PLPSPATTEG GSLTPVRDSP CTPRLRSVSS YGNIRAVTTA RSLNKSLQNL SLTEESGSSV
AFSPGNLSTS SSASSTLGSP ENEEYILSFE TIDKMRRVSS YSALNSLIGV SFNSVYTQIW
RVLLHLAADP YPDVSDLAMK VLNSIAYKAT VNARPQRILT TSSLTQSAPA SPTNKGIHIH
QAGGSPPTSS ASSSSLTNDV AKQPVGRDLP AGRPGAPGPA GVQYTPHSQQ FPRTRKMFDK
GPDQTTDDAD DAAGHRSFVS ATTQTGFCDW SARYFAQPVM KIPEEHDLES QIRKEREWRF
LRNTHVRQQA RQLIQKGIAR LDDQIFLNRN PGVPSVVKFH PFTPCVAVAD KDSICFWDWE
KGEKLDYFHN GNPRYTRVTA MEYLNGQDCS LLLTATDDGA IRVWKNFADL EKNPEMVTAW
QGLSDMLPTT RGAGMVVDWE QETGLLMSSG DVRIVRIWDT DREMKVQDIP TGADSCVTSL
SCDSHRSLIV AGLGDGSIRV YDRRMALSEC RVMTYREHTA WVVKAYLQKH PEGHIMSVSV
NGDVRFFDPR MPESVNVLQI VKGLTALDIH PQANLIACGS MNQFTAIYSG NGELINNIKY
YDGFMGQRVG AISCLAFHPH WPHLAVGSND YYISVYSVEK RAR
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