ID A0A337SNF4_FELCA Unreviewed; 701 AA.
AC A0A337SNF4;
DT 10-OCT-2018, integrated into UniProtKB/TrEMBL.
DT 10-OCT-2018, sequence version 1.
DT 27-MAR-2024, entry version 23.
DE SubName: Full=Leucine rich repeat and sterile alpha motif containing 1 {ECO:0000313|Ensembl:ENSFCAP00000047592.1};
GN Name=LRSAM1 {ECO:0000313|Ensembl:ENSFCAP00000047592.1,
GN ECO:0000313|VGNC:VGNC:63318};
OS Felis catus (Cat) (Felis silvestris catus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Carnivora; Feliformia; Felidae; Felinae; Felis.
OX NCBI_TaxID=9685 {ECO:0000313|Ensembl:ENSFCAP00000047592.1, ECO:0000313|Proteomes:UP000011712};
RN [1] {ECO:0000313|Ensembl:ENSFCAP00000047592.1, ECO:0000313|Proteomes:UP000011712}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Abyssinian {ECO:0000313|Ensembl:ENSFCAP00000047592.1,
RC ECO:0000313|Proteomes:UP000011712};
RX PubMed=17975172; DOI=10.1101/gr.6380007;
RA Pontius J.U., Mullikin J.C., Smith D.R., Lindblad-Toh K., Gnerre S.,
RA Clamp M., Chang J., Stephens R., Neelam B., Volfovsky N., Schaffer A.A.,
RA Agarwala R., Narfstrom K., Murphy W.J., Giger U., Roca A.L., Antunes A.,
RA Menotti-Raymond M., Yuhki N., Pecon-Slattery J., Johnson W.E., Bourque G.,
RA Tesler G., O'Brien S.J.;
RT "Initial sequence and comparative analysis of the cat genome.";
RL Genome Res. 17:1675-1689(2007).
RN [2] {ECO:0000313|Ensembl:ENSFCAP00000047592.1, ECO:0000313|Proteomes:UP000011712}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Abyssinian {ECO:0000313|Ensembl:ENSFCAP00000047592.1,
RC ECO:0000313|Proteomes:UP000011712};
RA Hillier L.W., Warren W., Obrien S., Wilson R.K.;
RT "Sequence assembly of the Felis catus genome version 6.2.";
RL Submitted (SEP-2011) to the EMBL/GenBank/DDBJ databases.
RN [3] {ECO:0000313|Ensembl:ENSFCAP00000047592.1}
RP IDENTIFICATION.
RC STRAIN=breed Abyssinian {ECO:0000313|Ensembl:ENSFCAP00000047592.1};
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
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DR EMBL; AANG04002451; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR RefSeq; XP_011286726.1; XM_011288424.2.
DR AlphaFoldDB; A0A337SNF4; -.
DR Ensembl; ENSFCAT00000052528.2; ENSFCAP00000047592.1; ENSFCAG00000023536.4.
DR GeneID; 101096519; -.
DR CTD; 90678; -.
DR VGNC; VGNC:63318; LRSAM1.
DR GeneTree; ENSGT00930000151044; -.
DR OrthoDB; 1043058at2759; -.
DR Proteomes; UP000011712; Chromosome D4.
DR Bgee; ENSFCAG00000023536; Expressed in liver and 10 other cell types or tissues.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR CDD; cd16515; RING-HC_LRSAM1; 1.
DR CDD; cd09523; SAM_TAL; 1.
DR Gene3D; 3.80.10.10; Ribonuclease Inhibitor; 1.
DR Gene3D; 1.10.150.50; Transcription Factor, Ets-1; 1.
DR Gene3D; 3.30.40.10; Zinc/RING finger domain, C3HC4 (zinc finger); 1.
DR InterPro; IPR001611; Leu-rich_rpt.
DR InterPro; IPR003591; Leu-rich_rpt_typical-subtyp.
DR InterPro; IPR032675; LRR_dom_sf.
DR InterPro; IPR001660; SAM.
DR InterPro; IPR013761; SAM/pointed_sf.
DR InterPro; IPR001841; Znf_RING.
DR InterPro; IPR013083; Znf_RING/FYVE/PHD.
DR PANTHER; PTHR48051; -; 1.
DR PANTHER; PTHR48051:SF46; LEUCINE RICH REPEAT AND STERILE ALPHA MOTIF CONTAINING 1; 1.
DR Pfam; PF13855; LRR_8; 1.
DR Pfam; PF00536; SAM_1; 1.
DR Pfam; PF13920; zf-C3HC4_3; 1.
DR SMART; SM00364; LRR_BAC; 4.
DR SMART; SM00369; LRR_TYP; 4.
DR SUPFAM; SSF52058; L domain-like; 1.
DR SUPFAM; SSF57850; RING/U-box; 1.
DR SUPFAM; SSF47769; SAM/Pointed domain; 1.
DR PROSITE; PS51450; LRR; 1.
DR PROSITE; PS50105; SAM_DOMAIN; 1.
DR PROSITE; PS50089; ZF_RING_2; 1.
PE 4: Predicted;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Leucine-rich repeat {ECO:0000256|ARBA:ARBA00022614};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Reference proteome {ECO:0000313|Proteomes:UP000011712};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Zinc {ECO:0000256|ARBA:ARBA00022833};
KW Zinc-finger {ECO:0000256|ARBA:ARBA00022771, ECO:0000256|PROSITE-
KW ProRule:PRU00175}.
FT DOMAIN 538..605
FT /note="SAM"
FT /evidence="ECO:0000259|PROSITE:PS50105"
FT DOMAIN 653..688
FT /note="RING-type"
FT /evidence="ECO:0000259|PROSITE:PS50089"
FT COILED 310..376
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 484..519
FT /evidence="ECO:0000256|SAM:Coils"
SQ SEQUENCE 701 AA; 80911 MW; 30ADAD1473BB9AEF CRC64;
MPLFFRKRKP SEEARKRLEY QMCLAKEAGA DDILDISKCE LSEIPFGAFA TCKVLQKKVL
IVHTNHLTYL LPKSCSLLSL ATIKVLDLHD NQLSALPDDI GQLTALQVLN VERNQLTYLP
RSIGNLIQLQ TLNVKDNKLR ELPDTVGELR SLRTLDISEN EIQRLPQLLA HVRTLETLSL
DASSMVYPPQ EVCSAGTQAI QQFLCKESGL EYYPPSQYLL PVLEQDGADA SWDSPDGPTD
RFSREEAEWQ NRFSDYEKRK EQKMLEKLEF ERRLELGQRE HAQLLQQSSS QKDEILQTVK
EEQSRLEQGL SEHQRYLDAE RQRLQEQLKQ TEQNIANRIQ KLLQDNQRQK KSSEILKSLE
NERIRMEQLM SITQEETENL RRREIASAMQ QMLTESCTNR LIQVAYESQR QNLVQQACSS
MAEMDERFQQ ILSWQQMDQN KAISQILQES AMQKAAFEAL QVKKDLMHRQ IRKQEMISEQ
RWALSSLLQQ LLKEKTQREE ELREILTELE AKSETRQENY WLIQYQRLLN QKPLSLKLQE
EGMERQLAAL LVDLSAEHYL PIFAHHRISL DTLSRMSPGD LAKVGVSEAG LQHEILRRVR
ELLGAARIQP EPLNPPKGEV PGAMEVPTAP EELPESVSPS APPAELEVQT SECVVCLEQE
AQMIFLNCGH VCCCQQCCQP LRTCPLCRRE IVQRLRIYHS G
//
