ID A0A337SNY7_FELCA Unreviewed; 749 AA.
AC A0A337SNY7;
DT 10-OCT-2018, integrated into UniProtKB/TrEMBL.
DT 11-DEC-2019, sequence version 2.
DT 27-MAR-2024, entry version 23.
DE RecName: Full=phosphoinositide 5-phosphatase {ECO:0000256|ARBA:ARBA00013044};
DE EC=3.1.3.36 {ECO:0000256|ARBA:ARBA00013044};
GN Name=INPP5B {ECO:0000313|VGNC:VGNC:67808};
OS Felis catus (Cat) (Felis silvestris catus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Carnivora; Feliformia; Felidae; Felinae; Felis.
OX NCBI_TaxID=9685 {ECO:0000313|Ensembl:ENSFCAP00000047334.2, ECO:0000313|Proteomes:UP000011712};
RN [1] {ECO:0000313|Ensembl:ENSFCAP00000047334.2, ECO:0000313|Proteomes:UP000011712}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Abyssinian {ECO:0000313|Ensembl:ENSFCAP00000047334.2,
RC ECO:0000313|Proteomes:UP000011712};
RX PubMed=17975172; DOI=10.1101/gr.6380007;
RA Pontius J.U., Mullikin J.C., Smith D.R., Lindblad-Toh K., Gnerre S.,
RA Clamp M., Chang J., Stephens R., Neelam B., Volfovsky N., Schaffer A.A.,
RA Agarwala R., Narfstrom K., Murphy W.J., Giger U., Roca A.L., Antunes A.,
RA Menotti-Raymond M., Yuhki N., Pecon-Slattery J., Johnson W.E., Bourque G.,
RA Tesler G., O'Brien S.J.;
RT "Initial sequence and comparative analysis of the cat genome.";
RL Genome Res. 17:1675-1689(2007).
RN [2] {ECO:0000313|Ensembl:ENSFCAP00000047334.2, ECO:0000313|Proteomes:UP000011712}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Abyssinian {ECO:0000313|Ensembl:ENSFCAP00000047334.2,
RC ECO:0000313|Proteomes:UP000011712};
RA Hillier L.W., Warren W., Obrien S., Wilson R.K.;
RT "Sequence assembly of the Felis catus genome version 6.2.";
RL Submitted (SEP-2011) to the EMBL/GenBank/DDBJ databases.
RN [3] {ECO:0000313|Ensembl:ENSFCAP00000047334.2}
RP IDENTIFICATION.
RC STRAIN=breed Abyssinian {ECO:0000313|Ensembl:ENSFCAP00000047334.2};
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cytoplasmic vesicle, phagosome membrane
CC {ECO:0000256|ARBA:ARBA00004580}. Early endosome membrane
CC {ECO:0000256|ARBA:ARBA00004146}. Endosome membrane
CC {ECO:0000256|ARBA:ARBA00004608}. Membrane
CC {ECO:0000256|ARBA:ARBA00004370}.
CC -!- SIMILARITY: Belongs to the inositol 1,4,5-trisphosphate 5-phosphatase
CC type II family. {ECO:0000256|ARBA:ARBA00005910}.
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DR EMBL; AANG04003369; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; A0A337SNY7; -.
DR Ensembl; ENSFCAT00000062249.2; ENSFCAP00000047334.2; ENSFCAG00000011021.6.
DR VGNC; VGNC:67808; INPP5B.
DR GeneTree; ENSGT00940000156762; -.
DR Proteomes; UP000011712; Chromosome C1.
DR Bgee; ENSFCAG00000011021; Expressed in spleen and 9 other cell types or tissues.
DR GO; GO:0031901; C:early endosome membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0030670; C:phagocytic vesicle membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0052745; F:inositol phosphate phosphatase activity; IEA:InterPro.
DR GO; GO:0004439; F:phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity; IEA:UniProtKB-EC.
DR GO; GO:0046856; P:phosphatidylinositol dephosphorylation; IEA:InterPro.
DR GO; GO:0007165; P:signal transduction; IEA:InterPro.
DR CDD; cd09093; INPP5c_INPP5B; 1.
DR CDD; cd04380; RhoGAP_OCRL1; 1.
DR Gene3D; 3.60.10.10; Endonuclease/exonuclease/phosphatase; 1.
DR Gene3D; 2.60.40.10; Immunoglobulins; 1.
DR Gene3D; 1.10.555.10; Rho GTPase activation protein; 1.
DR InterPro; IPR036691; Endo/exonu/phosph_ase_sf.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR046985; IP5.
DR InterPro; IPR000300; IPPc.
DR InterPro; IPR048869; OCRL-1_2_ASH.
DR InterPro; IPR037793; OCRL1/INPP5B_INPP5c.
DR InterPro; IPR008936; Rho_GTPase_activation_prot.
DR InterPro; IPR000198; RhoGAP_dom.
DR InterPro; IPR047078; RhoGAP_OCRL1.
DR PANTHER; PTHR11200; INOSITOL 5-PHOSPHATASE; 1.
DR PANTHER; PTHR11200:SF163; TYPE II INOSITOL 1,4,5-TRISPHOSPHATE 5-PHOSPHATASE; 1.
DR Pfam; PF21310; OCRL-like_ASH; 1.
DR Pfam; PF00620; RhoGAP; 1.
DR SMART; SM00128; IPPc; 1.
DR SMART; SM00324; RhoGAP; 1.
DR SUPFAM; SSF56219; DNase I-like; 1.
DR SUPFAM; SSF48350; GTPase activation domain, GAP; 1.
DR PROSITE; PS50238; RHOGAP; 1.
PE 3: Inferred from homology;
KW Cytoplasmic vesicle {ECO:0000256|ARBA:ARBA00023329};
KW Endosome {ECO:0000256|ARBA:ARBA00022753};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Lipid metabolism {ECO:0000256|ARBA:ARBA00023098};
KW Reference proteome {ECO:0000313|Proteomes:UP000011712}.
FT DOMAIN 577..749
FT /note="Rho-GAP"
FT /evidence="ECO:0000259|PROSITE:PS50238"
FT REGION 1..23
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 749 AA; 85488 MW; 72D6BE995C6B2F45 CRC64;
MSAASGSREC DSAGVFDFDD SRSDGKGMLV DQSSWGQDTA DNLLTRQNKS KSDIINMVRS
STITVSDKAH ILSIQKFGLR DTIVKSHLVQ REEDYTYIQN FRFFVGTYNV NGQSPKECLR
PWLSHGIEAP DVYCVGFQEL DLSKEAFFFH DTPKEEEWFK AVSEGLHPDA KYAKVKLIRL
VGIMLLLYVK QEHAAHISEV EAETVGTGIM GRMGNKGGVA IRFQLHNTSI CVVNSHLAAH
TEECERRNQD YKDICSRMQF CQADPSLPPL TISKHDVILW LGDLNYRIEE LDVETVKKLI
EEKAFQTLYA YDQLKTQVTA KTVFEDFTEG ELTFQPTYKY DTGSDDWDTS EKCRAPAWCD
RVLWKGKNIT QLSYQSHMAL KTSDHKPVSS VFDIGVKVVN EERYRKTLEE IVRSLDKMEN
ANIPSVFLSK REFCFQNVKY MQLQVQSFII HNGQVPCQFE FINKPDEESY CKQWLNANPS
RGFLLPDSAI EIELELFVNK TTATKLNSGE DKIEDILVLH LDRGKDYFLS VTGNYLPSCF
GSPIHTLCYM REPILDLPLE TIRELTLMPL QTEDDGIQLE NPMGIPKELW MMVDYLYQNA
IQQEDLFQQP GLRSEFEHIR DCLDTGMIDA LSANSHSVAE ALLLFLESLP EPVICYSAYQ
NCLECSGSYT ASKQVISTLP TFHQNVFNYL MAFLRELLKK SAKNHLDENI LASIFGSLLL
RNPAGHQKLD MAEKKKAQEF IHQFLCNSP
//
