ID A0A337SS96_FELCA Unreviewed; 579 AA.
AC A0A337SS96;
DT 10-OCT-2018, integrated into UniProtKB/TrEMBL.
DT 11-DEC-2019, sequence version 2.
DT 27-MAR-2024, entry version 28.
DE SubName: Full=GATA binding protein 6 {ECO:0000313|Ensembl:ENSFCAP00000050411.2};
GN Name=GATA6 {ECO:0000313|Ensembl:ENSFCAP00000050411.2,
GN ECO:0000313|VGNC:VGNC:62475};
OS Felis catus (Cat) (Felis silvestris catus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Carnivora; Feliformia; Felidae; Felinae; Felis.
OX NCBI_TaxID=9685 {ECO:0000313|Ensembl:ENSFCAP00000050411.2, ECO:0000313|Proteomes:UP000011712};
RN [1] {ECO:0000313|Ensembl:ENSFCAP00000050411.2, ECO:0000313|Proteomes:UP000011712}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Abyssinian {ECO:0000313|Ensembl:ENSFCAP00000050411.2,
RC ECO:0000313|Proteomes:UP000011712};
RX PubMed=17975172; DOI=10.1101/gr.6380007;
RA Pontius J.U., Mullikin J.C., Smith D.R., Lindblad-Toh K., Gnerre S.,
RA Clamp M., Chang J., Stephens R., Neelam B., Volfovsky N., Schaffer A.A.,
RA Agarwala R., Narfstrom K., Murphy W.J., Giger U., Roca A.L., Antunes A.,
RA Menotti-Raymond M., Yuhki N., Pecon-Slattery J., Johnson W.E., Bourque G.,
RA Tesler G., O'Brien S.J.;
RT "Initial sequence and comparative analysis of the cat genome.";
RL Genome Res. 17:1675-1689(2007).
RN [2] {ECO:0000313|Ensembl:ENSFCAP00000050411.2, ECO:0000313|Proteomes:UP000011712}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Abyssinian {ECO:0000313|Ensembl:ENSFCAP00000050411.2,
RC ECO:0000313|Proteomes:UP000011712};
RA Hillier L.W., Warren W., Obrien S., Wilson R.K.;
RT "Sequence assembly of the Felis catus genome version 6.2.";
RL Submitted (SEP-2011) to the EMBL/GenBank/DDBJ databases.
RN [3] {ECO:0000313|Ensembl:ENSFCAP00000050411.2}
RP IDENTIFICATION.
RC STRAIN=breed Abyssinian {ECO:0000313|Ensembl:ENSFCAP00000050411.2};
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
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DR EMBL; AANG04003548; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; A0A337SS96; -.
DR Ensembl; ENSFCAT00000063106.2; ENSFCAP00000050411.2; ENSFCAG00000027069.4.
DR VGNC; VGNC:62475; GATA6.
DR GeneTree; ENSGT00940000160814; -.
DR Proteomes; UP000011712; Chromosome D3.
DR Bgee; ENSFCAG00000027069; Expressed in embryo and 9 other cell types or tissues.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0003700; F:DNA-binding transcription factor activity; IEA:InterPro.
DR GO; GO:0000976; F:transcription cis-regulatory region binding; IEA:UniProt.
DR GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR GO; GO:0048856; P:anatomical structure development; IEA:UniProt.
DR GO; GO:0045944; P:positive regulation of transcription by RNA polymerase II; IEA:UniProt.
DR CDD; cd00202; ZnF_GATA; 2.
DR Gene3D; 3.30.50.10; Erythroid Transcription Factor GATA-1, subunit A; 2.
DR InterPro; IPR008013; GATA_N.
DR InterPro; IPR039355; Transcription_factor_GATA.
DR InterPro; IPR000679; Znf_GATA.
DR InterPro; IPR013088; Znf_NHR/GATA.
DR PANTHER; PTHR10071; TRANSCRIPTION FACTOR GATA FAMILY MEMBER; 1.
DR PANTHER; PTHR10071:SF23; TRANSCRIPTION FACTOR GATA-6; 1.
DR Pfam; PF00320; GATA; 2.
DR Pfam; PF05349; GATA-N; 1.
DR PRINTS; PR00619; GATAZNFINGER.
DR SMART; SM00401; ZnF_GATA; 2.
DR SUPFAM; SSF57716; Glucocorticoid receptor-like (DNA-binding domain); 2.
DR PROSITE; PS00344; GATA_ZN_FINGER_1; 2.
DR PROSITE; PS50114; GATA_ZN_FINGER_2; 2.
PE 4: Predicted;
KW Activator {ECO:0000256|ARBA:ARBA00023159};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Reference proteome {ECO:0000313|Proteomes:UP000011712};
KW Zinc {ECO:0000256|ARBA:ARBA00022833};
KW Zinc-finger {ECO:0000256|ARBA:ARBA00022771, ECO:0000256|PROSITE-
KW ProRule:PRU00094}.
FT DOMAIN 382..436
FT /note="GATA-type"
FT /evidence="ECO:0000259|PROSITE:PS50114"
FT DOMAIN 436..489
FT /note="GATA-type"
FT /evidence="ECO:0000259|PROSITE:PS50114"
FT REGION 20..72
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 211..253
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 484..545
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 498..542
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 579 AA; 58674 MW; F18CEA9F94790B3C CRC64;
MALTDGGWCL SKRFGAAAAD ASDSGAFPAR EPSTPPSPIS SSSSSCCSRG GERGPGGASN
CRTPQLDTEA AAGPPARSLL LSPYASHPFG APHGPSAPGV AGPGSALSSW EDLLLFTDLD
QAATASKLLW SSRGAKLSPF APEQPEEMYQ TLAALSSQGP AAYDGAPGGF VHSAAAAAAA
AAAASSPVYV PTTRVGSMLP GLPYLQGAGS GPANHAGGAG AHPGWPQASA DSPPYGSAGG
AAGGGAAGPG SAGSAAAHVS ARFPYSPSPP VANGAARDPG GYAAAGGGGA GGVGGGGGGS
LAAMGGREHQ YSSLSAARPL NGTYHHHHHH HPNPYSPYVG APLTPAWPAG PFETPVLHSL
QSRAGAPLPV PRGPSADLLE DLPESRECVN CGSIQTPLWR RDGTGHYLCN ACGLYSKMNG
LSRPLIKPQK RVPSSRRLGL SCANCHTTTT TLWRRNAEGE PVCNACGLYM KLHGVPRPLA
MKKEGIQTRK RKPKNINKSK ACSGSSNNSV PMTPTSTSSN SDDCSKNTSP TTQPTSSGKN
AKMPKNCILG MQDGVAHWPG SDVRRHSLHE MSFVGRTLH
//
