ID A0A337SU88_FELCA Unreviewed; 220 AA.
AC A0A337SU88;
DT 10-OCT-2018, integrated into UniProtKB/TrEMBL.
DT 11-DEC-2019, sequence version 2.
DT 27-MAR-2024, entry version 27.
DE RecName: Full=Toll/interleukin-1 receptor domain-containing adapter protein {ECO:0000256|PIRNR:PIRNR037750};
DE Short=TIR domain-containing adapter protein {ECO:0000256|PIRNR:PIRNR037750};
GN Name=TIRAP {ECO:0000313|Ensembl:ENSFCAP00000049447.2,
GN ECO:0000313|VGNC:VGNC:104335};
OS Felis catus (Cat) (Felis silvestris catus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Carnivora; Feliformia; Felidae; Felinae; Felis.
OX NCBI_TaxID=9685 {ECO:0000313|Ensembl:ENSFCAP00000049447.2, ECO:0000313|Proteomes:UP000011712};
RN [1] {ECO:0000313|Ensembl:ENSFCAP00000049447.2, ECO:0000313|Proteomes:UP000011712}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Abyssinian {ECO:0000313|Ensembl:ENSFCAP00000049447.2,
RC ECO:0000313|Proteomes:UP000011712};
RX PubMed=17975172; DOI=10.1101/gr.6380007;
RA Pontius J.U., Mullikin J.C., Smith D.R., Lindblad-Toh K., Gnerre S.,
RA Clamp M., Chang J., Stephens R., Neelam B., Volfovsky N., Schaffer A.A.,
RA Agarwala R., Narfstrom K., Murphy W.J., Giger U., Roca A.L., Antunes A.,
RA Menotti-Raymond M., Yuhki N., Pecon-Slattery J., Johnson W.E., Bourque G.,
RA Tesler G., O'Brien S.J.;
RT "Initial sequence and comparative analysis of the cat genome.";
RL Genome Res. 17:1675-1689(2007).
RN [2] {ECO:0000313|Ensembl:ENSFCAP00000049447.2, ECO:0000313|Proteomes:UP000011712}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Abyssinian {ECO:0000313|Ensembl:ENSFCAP00000049447.2,
RC ECO:0000313|Proteomes:UP000011712};
RA Hillier L.W., Warren W., Obrien S., Wilson R.K.;
RT "Sequence assembly of the Felis catus genome version 6.2.";
RL Submitted (SEP-2011) to the EMBL/GenBank/DDBJ databases.
RN [3] {ECO:0000313|Ensembl:ENSFCAP00000049447.2}
RP IDENTIFICATION.
RC STRAIN=breed Abyssinian {ECO:0000313|Ensembl:ENSFCAP00000049447.2};
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- FUNCTION: Adapter involved in the TLR2 and TLR4 signaling pathways in
CC the innate immune response. {ECO:0000256|PIRNR:PIRNR037750}.
CC -!- SUBUNIT: Homodimer. {ECO:0000256|PIRNR:PIRNR037750}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|PIRNR:PIRNR037750}. Cell
CC membrane {ECO:0000256|PIRNR:PIRNR037750}. Membrane
CC {ECO:0000256|PIRNR:PIRNR037750}.
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DR EMBL; AANG04002871; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; A0A337SU88; -.
DR STRING; 9685.ENSFCAP00000049447; -.
DR PaxDb; 9685-ENSFCAP00000022668; -.
DR Ensembl; ENSFCAT00000056038.2; ENSFCAP00000049447.2; ENSFCAG00000046185.2.
DR VGNC; VGNC:104335; TIRAP.
DR GeneTree; ENSGT00510000048428; -.
DR InParanoid; A0A337SU88; -.
DR OMA; RWKRKYD; -.
DR Proteomes; UP000011712; Chromosome D1.
DR Bgee; ENSFCAG00000046185; Expressed in adult mammalian kidney and 10 other cell types or tissues.
DR GO; GO:0009986; C:cell surface; IEA:Ensembl.
DR GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR GO; GO:0031234; C:extrinsic component of cytoplasmic side of plasma membrane; IEA:Ensembl.
DR GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
DR GO; GO:0042802; F:identical protein binding; IEA:UniProtKB-UniRule.
DR GO; GO:0005080; F:protein kinase C binding; IEA:Ensembl.
DR GO; GO:0035591; F:signaling adaptor activity; IEA:Ensembl.
DR GO; GO:0035663; F:Toll-like receptor 2 binding; IBA:GO_Central.
DR GO; GO:0035662; F:Toll-like receptor 4 binding; IBA:GO_Central.
DR GO; GO:0070935; P:3'-UTR-mediated mRNA stabilization; IEA:Ensembl.
DR GO; GO:0007249; P:canonical NF-kappaB signal transduction; IBA:GO_Central.
DR GO; GO:0006954; P:inflammatory response; IEA:UniProtKB-KW.
DR GO; GO:0045087; P:innate immune response; IEA:UniProtKB-KW.
DR GO; GO:0043123; P:positive regulation of canonical NF-kappaB signal transduction; IBA:GO_Central.
DR GO; GO:2000343; P:positive regulation of chemokine (C-X-C motif) ligand 2 production; IBA:GO_Central.
DR GO; GO:0070374; P:positive regulation of ERK1 and ERK2 cascade; IEA:Ensembl.
DR GO; GO:0032738; P:positive regulation of interleukin-15 production; IEA:Ensembl.
DR GO; GO:0032755; P:positive regulation of interleukin-6 production; IEA:Ensembl.
DR GO; GO:0032757; P:positive regulation of interleukin-8 production; IEA:Ensembl.
DR GO; GO:0046330; P:positive regulation of JNK cascade; IEA:Ensembl.
DR GO; GO:0031334; P:positive regulation of protein-containing complex assembly; IEA:Ensembl.
DR GO; GO:0034137; P:positive regulation of toll-like receptor 2 signaling pathway; IEA:Ensembl.
DR GO; GO:0034145; P:positive regulation of toll-like receptor 4 signaling pathway; IEA:Ensembl.
DR GO; GO:0032760; P:positive regulation of tumor necrosis factor production; IBA:GO_Central.
DR GO; GO:0032872; P:regulation of stress-activated MAPK cascade; IBA:GO_Central.
DR GO; GO:0032496; P:response to lipopolysaccharide; IEA:Ensembl.
DR GO; GO:0035665; P:TIRAP-dependent toll-like receptor 4 signaling pathway; IEA:Ensembl.
DR GO; GO:0034142; P:toll-like receptor 4 signaling pathway; IBA:GO_Central.
DR Gene3D; 3.40.50.10140; Toll/interleukin-1 receptor homology (TIR) domain; 1.
DR InterPro; IPR000157; TIR_dom.
DR InterPro; IPR017279; Tol-interleuk_rcpt_adapt_Tirap.
DR InterPro; IPR035897; Toll_tir_struct_dom_sf.
DR PANTHER; PTHR22662; TIRAP; 1.
DR PANTHER; PTHR22662:SF0; TOLL_INTERLEUKIN-1 RECEPTOR DOMAIN-CONTAINING ADAPTER PROTEIN; 1.
DR Pfam; PF13676; TIR_2; 1.
DR PIRSF; PIRSF037750; TIR_Tirap; 1.
DR SUPFAM; SSF52200; Toll/Interleukin receptor TIR domain; 1.
DR PROSITE; PS50104; TIR; 1.
PE 4: Predicted;
KW Cell membrane {ECO:0000256|PIRNR:PIRNR037750};
KW Cytoplasm {ECO:0000256|PIRNR:PIRNR037750};
KW Immunity {ECO:0000256|PIRNR:PIRNR037750};
KW Inflammatory response {ECO:0000256|PIRNR:PIRNR037750};
KW Innate immunity {ECO:0000256|PIRNR:PIRNR037750};
KW Membrane {ECO:0000256|PIRNR:PIRNR037750};
KW Reference proteome {ECO:0000313|Proteomes:UP000011712}.
FT DOMAIN 83..212
FT /note="TIR"
FT /evidence="ECO:0000259|PROSITE:PS50104"
FT REGION 1..82
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 40..81
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 220 AA; 23707 MW; 87440B7D7198BE00 CRC64;
MASSTSSAPR SRSRKPLGKM ADWFRQALSK KPKKILESSD GPSSDVSQPS SQDHPPRLGL
SSTSSPRSPA AAASSGSSGR WSKDYDVCVC HSEEDLAAAQ ELVSYLEGST ASLRCFLQLR
DATPGGAIVS ELCQALSNSH CRVLLITPGF LQDPWCKYQM LQALSEAPGA EGRTIPLMSG
LARAAYPAEL RFMYFVDGRG PDGGFRQVKE AVMRYLQTIS
//
