ID A0A337SV96_FELCA Unreviewed; 573 AA.
AC A0A337SV96;
DT 10-OCT-2018, integrated into UniProtKB/TrEMBL.
DT 10-OCT-2018, sequence version 1.
DT 24-JAN-2024, entry version 22.
DE SubName: Full=Chromobox 8 {ECO:0000313|Ensembl:ENSFCAP00000049958.1};
GN Name=CBX8 {ECO:0000313|Ensembl:ENSFCAP00000049958.1,
GN ECO:0000313|VGNC:VGNC:60426};
OS Felis catus (Cat) (Felis silvestris catus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Carnivora; Feliformia; Felidae; Felinae; Felis.
OX NCBI_TaxID=9685 {ECO:0000313|Ensembl:ENSFCAP00000049958.1, ECO:0000313|Proteomes:UP000011712};
RN [1] {ECO:0000313|Ensembl:ENSFCAP00000049958.1, ECO:0000313|Proteomes:UP000011712}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Abyssinian {ECO:0000313|Ensembl:ENSFCAP00000049958.1,
RC ECO:0000313|Proteomes:UP000011712};
RX PubMed=17975172; DOI=10.1101/gr.6380007;
RA Pontius J.U., Mullikin J.C., Smith D.R., Lindblad-Toh K., Gnerre S.,
RA Clamp M., Chang J., Stephens R., Neelam B., Volfovsky N., Schaffer A.A.,
RA Agarwala R., Narfstrom K., Murphy W.J., Giger U., Roca A.L., Antunes A.,
RA Menotti-Raymond M., Yuhki N., Pecon-Slattery J., Johnson W.E., Bourque G.,
RA Tesler G., O'Brien S.J.;
RT "Initial sequence and comparative analysis of the cat genome.";
RL Genome Res. 17:1675-1689(2007).
RN [2] {ECO:0000313|Ensembl:ENSFCAP00000049958.1, ECO:0000313|Proteomes:UP000011712}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Abyssinian {ECO:0000313|Ensembl:ENSFCAP00000049958.1,
RC ECO:0000313|Proteomes:UP000011712};
RA Hillier L.W., Warren W., Obrien S., Wilson R.K.;
RT "Sequence assembly of the Felis catus genome version 6.2.";
RL Submitted (SEP-2011) to the EMBL/GenBank/DDBJ databases.
RN [3] {ECO:0000313|Ensembl:ENSFCAP00000049958.1}
RP IDENTIFICATION.
RC STRAIN=breed Abyssinian {ECO:0000313|Ensembl:ENSFCAP00000049958.1};
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
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DR EMBL; AANG04004184; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; A0A337SV96; -.
DR STRING; 9685.ENSFCAP00000049958; -.
DR Ensembl; ENSFCAT00000066738.2; ENSFCAP00000049958.1; ENSFCAG00000031661.4.
DR VGNC; VGNC:60426; CBX8.
DR GeneTree; ENSGT00940000158476; -.
DR InParanoid; A0A337SV96; -.
DR OMA; HPENHGH; -.
DR Proteomes; UP000011712; Chromosome E1.
DR Bgee; ENSFCAG00000031661; Expressed in zone of skin and 10 other cell types or tissues.
DR GO; GO:0000785; C:chromatin; IBA:GO_Central.
DR GO; GO:0005654; C:nucleoplasm; IEA:Ensembl.
DR GO; GO:0035102; C:PRC1 complex; IBA:GO_Central.
DR GO; GO:0003682; F:chromatin binding; IBA:GO_Central.
DR GO; GO:0035064; F:methylated histone binding; IBA:GO_Central.
DR GO; GO:0000122; P:negative regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR Gene3D; 2.40.50.40; -; 1.
DR InterPro; IPR033773; CBX7_C.
DR PANTHER; PTHR46389:SF1; CHROMOBOX PROTEIN HOMOLOG 8; 1.
DR PANTHER; PTHR46389; POLYCOMB GROUP PROTEIN PC; 1.
DR Pfam; PF17218; CBX7_C; 1.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000011712}.
FT REGION 316..425
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 480..501
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 321..335
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 336..395
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 573 AA; 62990 MW; 757086A540E740B3 CRC64;
MELSAVGERV FAAEALLKRR IRKVGTPGPW TEAGRALPSR PGFPPPAAAQ LPFPQVPAAA
AAVAAAAAAL SPSAFLRLAA MHRLHGWGAG WGDECRCMHF VQRFVQGVMQ RARAFRDGIS
RIHLVHAFFA CISCVLVMHF SPCTHAFSPF ASAGTHGIPR EMEGLVAEVS RLYAILNPRL
LFGRFLSSSF SLYIEIQYNA TRKVTDVHTH SRRSFPVPGT DAHFFLISSR YSTWEPEENI
LDARLLAAFE EREREMELYG PKKRGPKPKT FLLKAQAKAK AKTYEFRSDS ARGIRIPYPG
RSPQDLASTS RAREGLRNMG LSPPGSSSST SSTCRVEPPR DRDRERERER ERERERERER
ERERGTSRTD DKPSSPGDSS KKRGPKPRKE LLDPSQRPLG EPSDGLGDYL KGRKLDEAPS
GAGKFPAGHS VIQLARRQDS DLAQCGVASP SPAEATGKLA VDTFPARVIK HRATFLEARG
QGTLDPGGPR VRHGSGTPGS VGGLYRDMGA QGGRPSLIAR IPVARILGDP EEESWSPSLT
NLEKVVVTDV TSNFLTVTIK ESNTDQGFFK EKR
//
