ID A0A338P7I4_MOUSE Unreviewed; 279 AA.
AC A0A338P7I4;
DT 10-OCT-2018, integrated into UniProtKB/TrEMBL.
DT 10-OCT-2018, sequence version 1.
DT 27-MAR-2024, entry version 29.
DE SubName: Full=Intersectin 1 (SH3 domain protein 1A) {ECO:0000313|Ensembl:ENSMUSP00000156289.2};
GN Name=Itsn1 {ECO:0000313|Ensembl:ENSMUSP00000156289.2,
GN ECO:0000313|MGI:MGI:1338069};
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090 {ECO:0000313|Ensembl:ENSMUSP00000156289.2, ECO:0000313|Proteomes:UP000000589};
RN [1] {ECO:0000313|Ensembl:ENSMUSP00000156289.2, ECO:0000313|Proteomes:UP000000589}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=C57BL/6J {ECO:0000313|Ensembl:ENSMUSP00000156289.2,
RC ECO:0000313|Proteomes:UP000000589};
RX PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
RA Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X.,
RA Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y.,
RA Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S.,
RA Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R.,
RA Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K.,
RA Eichler E.E., Ponting C.P.;
RT "Lineage-specific biology revealed by a finished genome assembly of the
RT mouse.";
RL PLoS Biol. 7:E1000112-E1000112(2009).
RN [2] {ECO:0007829|PubMed:21183079}
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX PubMed=21183079; DOI=10.1016/j.cell.2010.12.001;
RA Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R.,
RA Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.;
RT "A tissue-specific atlas of mouse protein phosphorylation and expression.";
RL Cell 143:1174-1189(2010).
RN [3] {ECO:0000313|Ensembl:ENSMUSP00000156289.2}
RP IDENTIFICATION.
RC STRAIN=C57BL/6J {ECO:0000313|Ensembl:ENSMUSP00000156289.2};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR Antibodypedia; 7532; 106 antibodies from 19 providers.
DR Ensembl; ENSMUST00000231735.2; ENSMUSP00000156289.2; ENSMUSG00000022957.21.
DR Ensembl; ENSMUST00000231852.2; ENSMUSP00000156129.2; ENSMUSG00000022957.21.
DR AGR; MGI:1338069; -.
DR MGI; MGI:1338069; Itsn1.
DR VEuPathDB; HostDB:ENSMUSG00000022957; -.
DR GeneTree; ENSGT00940000157065; -.
DR ChiTaRS; Itsn1; mouse.
DR Proteomes; UP000000589; Chromosome 16.
DR Bgee; ENSMUSG00000022957; Expressed in floor plate of midbrain and 277 other cell types or tissues.
DR CDD; cd08375; C2_Intersectin; 1.
DR CDD; cd13264; PH_ITSN; 1.
DR Gene3D; 2.60.40.150; C2 domain; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR InterPro; IPR000008; C2_dom.
DR InterPro; IPR035892; C2_domain_sf.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR001849; PH_domain.
DR PANTHER; PTHR46006:SF9; INTERSECTIN-2 ISOFORM X1; 1.
DR PANTHER; PTHR46006; RHO GUANINE NUCLEOTIDE EXCHANGE FACTOR AT 64C, ISOFORM A; 1.
DR Pfam; PF00168; C2; 1.
DR Pfam; PF16652; PH_13; 1.
DR SMART; SM00239; C2; 1.
DR SMART; SM00233; PH; 1.
DR SUPFAM; SSF49562; C2 domain (Calcium/lipid-binding domain, CaLB); 1.
DR SUPFAM; SSF50729; PH domain-like; 1.
DR PROSITE; PS50004; C2; 1.
DR PROSITE; PS50003; PH_DOMAIN; 1.
PE 1: Evidence at protein level;
KW Proteomics identification {ECO:0007829|MaxQB:A0A338P7I4,
KW ECO:0007829|PeptideAtlas:A0A338P7I4};
KW Reference proteome {ECO:0000313|Proteomes:UP000000589}.
FT DOMAIN 20..129
FT /note="PH"
FT /evidence="ECO:0000259|PROSITE:PS50003"
FT DOMAIN 137..253
FT /note="C2"
FT /evidence="ECO:0000259|PROSITE:PS50004"
SQ SEQUENCE 279 AA; 31859 MW; 157583492C6E38EF CRC64;
MPSLLQLVFN SVTNCLGPRK FLHSGKLYKA KSNKELYGFL FNDFLLLTQI TKPLGSSGTD
KVFSPKSNLQ YKMYKTPIFL NEVLVKLPTD PSGDEPIFHI SHIDRVYTLR AESINERTAW
VQKIKAASEL YIETEKKKRE KAYLVRSQRA TGIGRLMVNV VEGIELKPCR SHGKSNPYCE
VTMGSQCHIT KTIQDTLNPK WNSNCQFFIR DLEQEVLCIT VFERDQFSPD DFLGRTEIRV
ADIKKDQGSK GPVTKCLLLH EVPTGEIVVR LDLQLFDEP
//
