ID A0A340TB28_ANOME Unreviewed; 909 AA.
AC A0A340TB28;
DT 10-OCT-2018, integrated into UniProtKB/TrEMBL.
DT 10-OCT-2018, sequence version 1.
DT 24-JAN-2024, entry version 24.
DE RecName: Full=Alpha-catenin {ECO:0008006|Google:ProtNLM};
OS Anopheles merus (Mosquito).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Nematocera; Culicoidea; Culicidae;
OC Anophelinae; Anopheles.
OX NCBI_TaxID=30066 {ECO:0000313|EnsemblMetazoa:AMEM017470-PB, ECO:0000313|Proteomes:UP000075903};
RN [1] {ECO:0000313|Proteomes:UP000075903}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=MAF {ECO:0000313|Proteomes:UP000075903};
RG The Broad Institute Genomics Platform;
RA Neafsey D.E., Besansky N., Howell P., Walton C., Young S.K., Zeng Q.,
RA Gargeya S., Fitzgerald M., Haas B., Abouelleil A., Allen A.W., Alvarado L.,
RA Arachchi H.M., Berlin A.M., Chapman S.B., Gainer-Dewar J., Goldberg J.,
RA Griggs A., Gujja S., Hansen M., Howarth C., Imamovic A., Ireland A.,
RA Larimer J., McCowan C., Murphy C., Pearson M., Poon T.W., Priest M.,
RA Roberts A., Saif S., Shea T., Sisk P., Sykes S., Wortman J., Nusbaum C.,
RA Birren B.;
RT "The Genome Sequence of Anopheles merus MAF (V2).";
RL Submitted (JAN-2014) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EnsemblMetazoa:AMEM017470-PB}
RP IDENTIFICATION.
RC STRAIN=MAF {ECO:0000313|EnsemblMetazoa:AMEM017470-PB};
RG EnsemblMetazoa;
RL Submitted (MAY-2020) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cell junction, adherens junction
CC {ECO:0000256|ARBA:ARBA00004536}. Cell membrane
CC {ECO:0000256|ARBA:ARBA00004413}; Peripheral membrane protein
CC {ECO:0000256|ARBA:ARBA00004413}; Cytoplasmic side
CC {ECO:0000256|ARBA:ARBA00004413}. Cytoplasm, cytoskeleton
CC {ECO:0000256|ARBA:ARBA00004245}. Membrane
CC {ECO:0000256|ARBA:ARBA00004287}; Peripheral membrane protein
CC {ECO:0000256|ARBA:ARBA00004287}; Cytoplasmic side
CC {ECO:0000256|ARBA:ARBA00004287}.
CC -!- SIMILARITY: Belongs to the vinculin/alpha-catenin family.
CC {ECO:0000256|ARBA:ARBA00008376}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR AlphaFoldDB; A0A340TB28; -.
DR STRING; 30066.A0A340TB28; -.
DR EnsemblMetazoa; AMEM017470-RB; AMEM017470-PB; AMEM017470.
DR VEuPathDB; VectorBase:AMEM017470; -.
DR VEuPathDB; VectorBase:AMEM21_004470; -.
DR Proteomes; UP000075903; Unassembled WGS sequence.
DR GO; GO:0015629; C:actin cytoskeleton; IEA:InterPro.
DR GO; GO:0005912; C:adherens junction; IEA:UniProtKB-SubCell.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0051015; F:actin filament binding; IEA:InterPro.
DR GO; GO:0045296; F:cadherin binding; IEA:InterPro.
DR GO; GO:0005198; F:structural molecule activity; IEA:InterPro.
DR GO; GO:0007155; P:cell adhesion; IEA:UniProtKB-KW.
DR Gene3D; 6.10.250.2510; -; 1.
DR Gene3D; 1.20.120.230; Alpha-catenin/vinculin-like; 5.
DR InterPro; IPR036723; Alpha-catenin/vinculin-like_sf.
DR InterPro; IPR001033; Alpha_catenin.
DR InterPro; IPR006077; Vinculin/catenin.
DR InterPro; IPR000633; Vinculin_CS.
DR PANTHER; PTHR18914; ALPHA CATENIN; 1.
DR PANTHER; PTHR18914:SF9; CATENIN ALPHA; 1.
DR Pfam; PF01044; Vinculin; 1.
DR PRINTS; PR00805; ALPHACATENIN.
DR SUPFAM; SSF47220; alpha-catenin/vinculin-like; 4.
DR PROSITE; PS00663; VINCULIN_1; 1.
PE 3: Inferred from homology;
KW Cell adhesion {ECO:0000256|ARBA:ARBA00022889};
KW Cell junction {ECO:0000256|ARBA:ARBA00022949};
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Membrane {ECO:0000256|ARBA:ARBA00023136}.
FT REGION 869..909
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 869..886
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 889..909
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 909 AA; 102043 MW; C29511817890A341 CRC64;
METLSNFGQV ALKWDPKNLE IRTMSVEKTL EPLVLQVTTL VSTKGPSKKK KGKSKRASAL
VAAVEKATDI FIERGEQIAY ENPDITQEML SAVEEVRKTG SAMSIAAREF SEDPCSSLKR
GNMVRAARNL LSAVTRLLIL ADMVDVHLLL KSLHVVEDDL DKLRNASSQD ELMNNMRQFG
RNANELIKQA AKRQQELKDP QLRDDLAAAR AVLKKHSTML LTASKVYVRH PELDLAKVNR
DHILKQVCEA VNTISDVAQG KSSQPQDVYV GAGELAAALD DFDEGIIMDP RAYNEVRSRP
SLEERLESII SAAALMADAD CTRDERRERI VGECNAVRQA LQDLLSEYMS NMGTKDRTPE
LERAIGHMYR KTKDLRRQLR KAVVDHVSDS FLETNMPLLD LIDAARGGNE KLVRERADIF
TKHAEKLVEV ANLVCSMSNN EDGVKMVRYA ADQIETLCPQ VINAALILAA RPNSKVAQEN
MEAYRQAWEN QVRILTEAVD DITTIDDFLA VSENHILEDV NKCVLALQEG DAQDLRNTAG
AIQGRSARVC NVVEAEMDNY EPCIYTKRVL EAVKVLREQV MSKFAQRVDV AVDALSSNSP
KDVDENDFID ASRLVYDGVR EIRRAVLMNR DEEDLDPEDI EDEQYTLETR SKSSAHTGDQ
TIDEYPEISG ITTAREAMRK MNEEDKQKIM QQVELFRREK LTFDSEVAKW DDTGNDIIYL
AKHMCMIMME MTDFTRGRGP LKTTMDVINA AKKISEAGTK LDKLTREIAD QCPESSTKKD
LLAYLQRIAL YCHQIQITSK VKADVQNISG ELIVSGLDSA TSLIQAAKNL MNAVVYTVKY
SYVASTKYTR QGTVSSPIVV WKMKAPEKKP LVRPEKPEEV RAKVRRASQK KTQNPVHALS
EFQSPTDAV
//
