ID A0A340U1A4_GLOMM Unreviewed; 1170 AA.
AC A0A340U1A4;
DT 10-OCT-2018, integrated into UniProtKB/TrEMBL.
DT 10-OCT-2018, sequence version 1.
DT 13-SEP-2023, entry version 21.
DE RecName: Full=MHD domain-containing protein {ECO:0008006|Google:ProtNLM};
OS Glossina morsitans morsitans (Savannah tsetse fly).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Hippoboscoidea;
OC Glossinidae; Glossina.
OX NCBI_TaxID=37546 {ECO:0000313|EnsemblMetazoa:GMOY013317-PA, ECO:0000313|Proteomes:UP000092444};
RN [1] {ECO:0000313|Proteomes:UP000092444}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Yale {ECO:0000313|Proteomes:UP000092444};
RA Lawson D.;
RT "Genome Sequence of the Tsetse Fly (Glossina morsitans): Vector of African
RT Trypanosomiasis.";
RL Submitted (MAR-2014) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Proteomes:UP000092444}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Yale {ECO:0000313|Proteomes:UP000092444};
RG International Glossina Genome Initiative W.H.O.;
RA Lawson D.;
RT "Genome Sequence of the Tsetse Fly (Glossina morsitans): Vector of African
RT Trypanosomiasis.";
RL Submitted (MAR-2014) to the EMBL/GenBank/DDBJ databases.
RN [3] {ECO:0000313|EnsemblMetazoa:GMOY013317-PA}
RP IDENTIFICATION.
RC STRAIN=Yale {ECO:0000313|EnsemblMetazoa:GMOY013317-PA};
RG EnsemblMetazoa;
RL Submitted (MAY-2020) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Membrane, clathrin-coated pit
CC {ECO:0000256|ARBA:ARBA00004283}; Peripheral membrane protein
CC {ECO:0000256|ARBA:ARBA00004283}; Cytoplasmic side
CC {ECO:0000256|ARBA:ARBA00004283}.
CC -!- SIMILARITY: Belongs to the FCHO family.
CC {ECO:0000256|ARBA:ARBA00011064}.
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DR EMBL; CCAG010002237; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; A0A340U1A4; -.
DR STRING; 37546.A0A340U1A4; -.
DR EnsemblMetazoa; GMOY013317-RA; GMOY013317-PA; GMOY013317.
DR VEuPathDB; VectorBase:GMOY013317; -.
DR Proteomes; UP000092444; Unassembled WGS sequence.
DR GO; GO:0005905; C:clathrin-coated pit; IEA:UniProtKB-SubCell.
DR CDD; cd09265; AP_Syp1_like_MHD; 1.
DR CDD; cd07648; F-BAR_FCHO; 1.
DR Gene3D; 1.20.1270.60; Arfaptin homology (AH) domain/BAR domain; 1.
DR InterPro; IPR027267; AH/BAR_dom_sf.
DR InterPro; IPR031160; F_BAR.
DR InterPro; IPR001060; FCH_dom.
DR InterPro; IPR028565; MHD.
DR InterPro; IPR018808; Muniscin_C.
DR PANTHER; PTHR23065:SF15; AT02057P; 1.
DR PANTHER; PTHR23065; PROLINE-SERINE-THREONINE PHOSPHATASE INTERACTING PROTEIN 1; 1.
DR Pfam; PF00611; FCH; 1.
DR Pfam; PF10291; muHD; 1.
DR SMART; SM00055; FCH; 1.
DR SUPFAM; SSF103657; BAR/IMD domain-like; 1.
DR PROSITE; PS51741; F_BAR; 1.
DR PROSITE; PS51072; MHD; 1.
PE 3: Inferred from homology;
KW Coiled coil {ECO:0000256|PROSITE-ProRule:PRU01077, ECO:0000256|SAM:Coils}.
FT DOMAIN 3..249
FT /note="F-BAR"
FT /evidence="ECO:0000259|PROSITE:PS51741"
FT DOMAIN 876..1144
FT /note="MHD"
FT /evidence="ECO:0000259|PROSITE:PS51072"
FT REGION 350..385
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 425..542
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 717..759
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 793..822
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1146..1170
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 135..182
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 425..490
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 502..519
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 793..817
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1148..1170
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1170 AA; 126353 MW; 83B213657A9CFAC7 CRC64;
MTVDFNDYFW GEKNNGFDVL YHNMKYGLVA SKELSEFFRE KSNIEEQNSK LMSKLAHKAS
TGTLNSTFAP VWTILRTSAE KLSTLHMQMV QKLTELVKDV AKYADELHKK HKSVKEEESQ
TLDCVKAIQS STTEVQKARD LYSNKVLELE KLRKDSASQK DIEKLETKLR KLQEDYKVLL
EKHNPIKNEF ERRMTQTCKR FQEIEEVHLR QMKEFLSTYL ELLQNNHDMV GQVHSDFKRQ
FLDMTVDKLL EQFVLNKYTG LEKPEMPELE FIPLSINQQL SATSATRLNQ PNTASISSTT
NSNSATSINR AGAILMDQRG LEASSLGSAA SGSVGLVNND DTIVASSAKI TTSATTSTSR
PTSPELAAAS ATGNAAATGS NSSTATATTV KSNFLNWFSS NIPSKSHQQQ QHNVGLNATA
TTSASGNFGM ASNGTNNNSI STSTTTTTTT STSTTNTATK TTTTGTTIKN PLNSELQSLQ
DNNNQVSGIL RSRRDKAKTK KSKKKKDGDL GDNIQEERTQ SVDRLNSGLD YDDHNRMKSQ
SSVGSSAIGL ALSSTAGSSS GITIGNVDSS GSTVINATAI SSTTNITNNN ATTNICDILI
NSSASGGGSG GGDALNTKAN SSGVTINATT VSNNFKGNEV DEDGYSLQPP KEIAWEENHE
NAGSFYSDSD SDSDNDKPER RIHVKIKPLN NGQAPMSASV DELRATVENI SLSPTGVFSH
HSQQLQQPSR LTSRQQSPEI SNASTPTATV HPYAPLQSPT LSMSNNSRYA DLGDIFSELG
DVSISAPASA NLTKTQSRQI PTPTSGTGTS SSIAIPRPPS RRSEMVVAGA RGRISPAPIN
AMNRADSIGS LEFRTAIGGI GSSRGPSPLT IGISDTIPLA VAFHEIIHAY FRGSDESRCQ
VKISGDMMLS FPAGIAGLLA NNPNPSKLGF RIKNVQNLDN FIPNSKLVQV DKNQSSSFST
MLEFNMPALT ALLRRQAEHN PTASYFNVDI LKYQVRTKPG ASSCPFQLVS YWKCEPTFTA
LKIDYKYNNH AMASACPLLN VTLSVPVNGS VRNVQSKPHS AWLGESNRLV WNFTDISQNS
PDGGVGTLRA RLELGDGPST PALLSTQFNC EGTTLSGIEF ELQGSGYRLS LVKRRFVSGK
YVCEGDGIRS TTTPTPPSVG SSSPFSAKSN
//
