ID A0A340WFZ6_LIPVE Unreviewed; 256 AA.
AC A0A340WFZ6;
DT 10-OCT-2018, integrated into UniProtKB/TrEMBL.
DT 10-OCT-2018, sequence version 1.
DT 27-MAR-2024, entry version 23.
DE RecName: Full=Ferritin {ECO:0000256|RuleBase:RU361145};
GN Name=LOC103075683 {ECO:0000313|RefSeq:XP_007448523.1};
OS Lipotes vexillifer (Yangtze river dolphin).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Whippomorpha; Cetacea; Odontoceti;
OC Lipotidae; Lipotes.
OX NCBI_TaxID=118797 {ECO:0000313|Proteomes:UP000265300, ECO:0000313|RefSeq:XP_007448523.1};
RN [1] {ECO:0000313|RefSeq:XP_007448523.1}
RP IDENTIFICATION.
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- FUNCTION: Stores iron in a soluble, non-toxic, readily available form
CC (By similarity). Important for iron homeostasis (By similarity). Has
CC ferroxidase activity (By similarity). Iron is taken up in the ferrous
CC form and deposited as ferric hydroxides after oxidation (By
CC similarity). Also plays a role in delivery of iron to cells (By
CC similarity). Mediates iron uptake in capsule cells of the developing
CC kidney. {ECO:0000256|ARBA:ARBA00037207}.
CC -!- FUNCTION: Stores iron in a soluble, non-toxic, readily available form.
CC Important for iron homeostasis. Iron is taken up in the ferrous form
CC and deposited as ferric hydroxides after oxidation.
CC {ECO:0000256|RuleBase:RU361145}.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=4 Fe(2+) + 4 H(+) + O2 = 4 Fe(3+) + 2 H2O;
CC Xref=Rhea:RHEA:11148, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378,
CC ChEBI:CHEBI:15379, ChEBI:CHEBI:29033, ChEBI:CHEBI:29034; EC=1.16.3.1;
CC Evidence={ECO:0000256|ARBA:ARBA00001830};
CC -!- SUBUNIT: Oligomer of 24 subunits. There are two types of subunits: L
CC (light) chain and H (heavy) chain. The major chain can be light or
CC heavy, depending on the species and tissue type. The functional
CC molecule forms a roughly spherical shell with a diameter of 12 nm and
CC contains a central cavity into which the insoluble mineral iron core is
CC deposited. {ECO:0000256|ARBA:ARBA00026060}.
CC -!- SIMILARITY: Belongs to the ferritin family.
CC {ECO:0000256|ARBA:ARBA00007513, ECO:0000256|RuleBase:RU361145}.
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DR RefSeq; XP_007448523.1; XM_007448461.1.
DR AlphaFoldDB; A0A340WFZ6; -.
DR STRING; 118797.A0A340WFZ6; -.
DR GeneID; 103075683; -.
DR KEGG; lve:103075683; -.
DR InParanoid; A0A340WFZ6; -.
DR OrthoDB; 4611704at2759; -.
DR Proteomes; UP000265300; Unplaced.
DR GO; GO:0008199; F:ferric iron binding; IEA:InterPro.
DR GO; GO:0006879; P:intracellular iron ion homeostasis; IEA:UniProtKB-KW.
DR GO; GO:0006826; P:iron ion transport; IEA:InterPro.
DR CDD; cd01056; Euk_Ferritin; 1.
DR Gene3D; 1.20.1260.10; -; 1.
DR InterPro; IPR001519; Ferritin.
DR InterPro; IPR012347; Ferritin-like.
DR InterPro; IPR009040; Ferritin-like_diiron.
DR InterPro; IPR009078; Ferritin-like_SF.
DR InterPro; IPR014034; Ferritin_CS.
DR InterPro; IPR008331; Ferritin_DPS_dom.
DR PANTHER; PTHR11431; FERRITIN; 1.
DR PANTHER; PTHR11431:SF37; FERRITIN HEAVY CHAIN; 1.
DR Pfam; PF00210; Ferritin; 1.
DR SUPFAM; SSF47240; Ferritin-like; 1.
DR PROSITE; PS00204; FERRITIN_2; 1.
DR PROSITE; PS50905; FERRITIN_LIKE; 1.
PE 3: Inferred from homology;
KW Iron {ECO:0000256|ARBA:ARBA00023004, ECO:0000256|RuleBase:RU361145};
KW Iron storage {ECO:0000256|ARBA:ARBA00022434,
KW ECO:0000256|RuleBase:RU361145};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723,
KW ECO:0000256|RuleBase:RU361145};
KW Reference proteome {ECO:0000313|Proteomes:UP000265300}.
FT DOMAIN 84..233
FT /note="Ferritin-like diiron"
FT /evidence="ECO:0000259|PROSITE:PS50905"
FT REGION 22..88
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 61..88
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 256 AA; 29050 MW; 27003FB572BAD886 CRC64;
MRLNIKSRVL AESRRGFLLQ QCLDGTRRSS PAPAGRSEPA LATTSRRPPT APRSPPPLQR
RAATATVSPQ PPAMTTASPS QVRQNYHQDS EAAINSQINL ELHASYVYLS MSYYLDRDDV
ALKNFAKYFL HQSCEEREHA EELRKLQNQR GGRIFLQEIR KPDRDDWENG LNAMECALHL
EKSVTQSLLE LHKLATEKND PYLCDFIETH YLNEQVKSIK ELGDHVTNLR TMGAPESGMA
QYLFDKHTLG NSDNES
//
