ID A0A340WGS8_LIPVE Unreviewed; 483 AA.
AC A0A340WGS8;
DT 10-OCT-2018, integrated into UniProtKB/TrEMBL.
DT 10-OCT-2018, sequence version 1.
DT 27-MAR-2024, entry version 26.
DE SubName: Full=Class E basic helix-loop-helix protein 41 {ECO:0000313|RefSeq:XP_007446369.1};
GN Name=BHLHE41 {ECO:0000313|RefSeq:XP_007446369.1};
OS Lipotes vexillifer (Yangtze river dolphin).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Whippomorpha; Cetacea; Odontoceti;
OC Lipotidae; Lipotes.
OX NCBI_TaxID=118797 {ECO:0000313|Proteomes:UP000265300, ECO:0000313|RefSeq:XP_007446369.1};
RN [1] {ECO:0000313|RefSeq:XP_007446369.1}
RP IDENTIFICATION.
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
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DR RefSeq; XP_007446369.1; XM_007446307.1.
DR AlphaFoldDB; A0A340WGS8; -.
DR STRING; 118797.A0A340WGS8; -.
DR GeneID; 103085189; -.
DR KEGG; lve:103085189; -.
DR CTD; 79365; -.
DR InParanoid; A0A340WGS8; -.
DR OrthoDB; 2968390at2759; -.
DR Proteomes; UP000265300; Unplaced.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR GO; GO:0046983; F:protein dimerization activity; IEA:InterPro.
DR GO; GO:0006355; P:regulation of DNA-templated transcription; IEA:InterPro.
DR CDD; cd19750; bHLH-O_DEC2; 1.
DR Gene3D; 6.10.250.980; -; 1.
DR Gene3D; 4.10.280.10; Helix-loop-helix DNA-binding domain; 1.
DR InterPro; IPR011598; bHLH_dom.
DR InterPro; IPR036638; HLH_DNA-bd_sf.
DR InterPro; IPR003650; Orange_dom.
DR PANTHER; PTHR10985; BASIC HELIX-LOOP-HELIX TRANSCRIPTION FACTOR, HES-RELATED; 1.
DR PANTHER; PTHR10985:SF76; CLASS E BASIC HELIX-LOOP-HELIX PROTEIN 41; 1.
DR Pfam; PF07527; Hairy_orange; 1.
DR Pfam; PF00010; HLH; 1.
DR SMART; SM00353; HLH; 1.
DR SMART; SM00511; ORANGE; 1.
DR SUPFAM; SSF47459; HLH, helix-loop-helix DNA-binding domain; 1.
DR SUPFAM; SSF158457; Orange domain-like; 1.
DR PROSITE; PS50888; BHLH; 1.
DR PROSITE; PS51054; ORANGE; 1.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000265300};
KW Repressor {ECO:0000256|ARBA:ARBA00022491}.
FT DOMAIN 44..99
FT /note="BHLH"
FT /evidence="ECO:0000259|PROSITE:PS50888"
FT DOMAIN 131..166
FT /note="Orange"
FT /evidence="ECO:0000259|PROSITE:PS51054"
FT REGION 229..292
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 439..483
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 245..262
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 465..483
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 483 AA; 50692 MW; F6C4D7A3CCCA19F8 CRC64;
MDEGIPHLQE RQLLEHRDFI GLDYPSLYMC KPKRSMKRDD SKDTYKLPHR LIEKKRRDRI
NECIAQLKDL LPEHLKLTTL GHLEKAVVLE LTLKHLKALT ALTEQQHQKI IALQNGERSL
KSPIQSDLDA FHSGFQTCAK EVLQYLARFE SWTPREPRCV QLINHLHAVA TQFLPTPQLL
TQQVPLSKGT GVPSAATPAG SGAAPCLERA GQKLEPLAHC VPVIQRTQPS AELAAENDTD
TDSGYGGEAE ARPDREKGKG AGASRVTIKQ EPPGDDSPAP KRMKLDSRSG GGGLGGGAAA
AAAALLGPDP ATPAALLRPD AALLSSLVAF GGGGGAPFAQ PAAAAAPFCL PFYFLSPSAA
AAYVQPFLDK SGLEKYLYPA AAAAPFPLLY PGIPAPAAAA AAAAAAAAAA AFPCLSSVLS
PPPEKAAAAA AATLLPHEVA PPGALHPAPP HGRTHLPFAV RSEPGNPESS AQEDPSQPGK
ETP
//
