ID A0A340WHB2_LIPVE Unreviewed; 915 AA.
AC A0A340WHB2;
DT 10-OCT-2018, integrated into UniProtKB/TrEMBL.
DT 10-OCT-2018, sequence version 1.
DT 27-MAR-2024, entry version 24.
DE SubName: Full=Nuclear factor of activated T-cells, cytoplasmic 2 isoform X2 {ECO:0000313|RefSeq:XP_007446430.1};
GN Name=NFATC2 {ECO:0000313|RefSeq:XP_007446430.1};
OS Lipotes vexillifer (Yangtze river dolphin).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Whippomorpha; Cetacea; Odontoceti;
OC Lipotidae; Lipotes.
OX NCBI_TaxID=118797 {ECO:0000313|Proteomes:UP000265300, ECO:0000313|RefSeq:XP_007446430.1};
RN [1] {ECO:0000313|RefSeq:XP_007446430.1}
RP IDENTIFICATION.
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
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DR RefSeq; XP_007446430.1; XM_007446368.1.
DR AlphaFoldDB; A0A340WHB2; -.
DR GeneID; 103083433; -.
DR CTD; 4773; -.
DR OrthoDB; 5405363at2759; -.
DR Proteomes; UP000265300; Unplaced.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProt.
DR GO; GO:0043229; C:intracellular organelle; IEA:UniProt.
DR GO; GO:0043227; C:membrane-bounded organelle; IEA:UniProt.
DR GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR GO; GO:0003700; F:DNA-binding transcription factor activity; IEA:InterPro.
DR CDD; cd01178; IPT_NFAT; 1.
DR CDD; cd07881; RHD-n_NFAT; 1.
DR Gene3D; 2.60.40.10; Immunoglobulins; 1.
DR Gene3D; 2.60.40.340; Rel homology domain (RHD), DNA-binding domain; 1.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR014756; Ig_E-set.
DR InterPro; IPR002909; IPT_dom.
DR InterPro; IPR008366; NFAT.
DR InterPro; IPR008967; p53-like_TF_DNA-bd_sf.
DR InterPro; IPR032397; RHD_dimer.
DR InterPro; IPR011539; RHD_DNA_bind_dom.
DR InterPro; IPR037059; RHD_DNA_bind_dom_sf.
DR PANTHER; PTHR12533; NFAT; 1.
DR PANTHER; PTHR12533:SF4; NUCLEAR FACTOR OF ACTIVATED T-CELLS, CYTOPLASMIC 2; 1.
DR Pfam; PF16179; RHD_dimer; 1.
DR Pfam; PF00554; RHD_DNA_bind; 1.
DR PRINTS; PR01789; NUCFACTORATC.
DR SMART; SM00429; IPT; 1.
DR SUPFAM; SSF81296; E set domains; 1.
DR SUPFAM; SSF49417; p53-like transcription factors; 1.
DR PROSITE; PS50254; REL_2; 1.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000265300}.
FT DOMAIN 386..568
FT /note="RHD"
FT /evidence="ECO:0000259|PROSITE:PS50254"
FT REGION 1..30
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 195..292
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 833..854
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 915 AA; 99126 MW; B40877BB04FD96A7 CRC64;
MDAQEPQPDP DGGGAPGHEP GGSPQDEFDF SILFDYDYLN PIEEEPNAHK VASPPSGLAY
PDDVLDYGLK PYSPLASLSG EPPHRLGEPD RVGPQNFLCP AKPAGASGLS PRIEITPSHE
LMQAGGPFRM RDTGLMVEQP PLPGVAASPR FTLPVPGFEG YREPLCLSPA SSGSSASFIS
DTFSPYTSPC VSPNNGGPDD LCPQFQNIPA HYSPRTSPIM SPRTGLAEDS CLGRHSPVPR
PASRSSSPGT KRRHSCAGAL VAPLPGASPQ RSRSPSPQPR DDGAPAGYPP AAGSAVLMDA
LNSLAADSPC GIPPKMWKTS PSPSPVSSAP SKAGLPRHIY PAVEFLGPCE QEERRNSAPE
SILLVPPTWP KQLVPAIPIC SIPVTASLPP LEWPLSHQSG SYELRIEVQP KPHHRAHYET
EGSRGAVKAP TGGHPVVQLH GYMENKPLGL QIFIGTADER ILKPHAFYQV HRITGKTVTT
TSYEKIVGNT KVLEIPLEPK NNMRATIDCA GILKLRNADI ELRKGETDIG RKNTRVRLVF
RVHIPESSGR IVSLQTASNP IECSQRSAHE LPMVERQDID SCMVYGGQQM ILTGQNFTAE
SKVVFTEKTT DGQQIWEMEA TVDKDKSQPN MLFVEIPEYR NKHIRTSVKV NFCVINGKRK
RSQPQHFTYH PVPAIKTEPT DEYDPTLICS PAHGGLGSQP YYPQHPMVAE SPSCLVATMA
PCQQFRSGLS SPDARYQQQN PAAVLYQRSK SLSPSLLGYQ QPALMAAPLS LADAHRSVLV
HAGSQGQSSA LLHSSPANQQ ASPVIHYSPT NQQLRCGSHQ EFQHIVYCEN FAPGPTRPGP
PPVSQGQRLS PGSYPTVIQQ QNATSQRAAK NGPPVSDQKE VLPAGVTIKQ EQNLDQTYLD
DELIDTHLSW IQNIL
//
