ID A0A340WI14_LIPVE Unreviewed; 333 AA.
AC A0A340WI14;
DT 10-OCT-2018, integrated into UniProtKB/TrEMBL.
DT 10-OCT-2018, sequence version 1.
DT 27-MAR-2024, entry version 22.
DE SubName: Full=Cathepsin L1-like {ECO:0000313|RefSeq:XP_007448361.1};
GN Name=LOC103089492 {ECO:0000313|RefSeq:XP_007448361.1};
OS Lipotes vexillifer (Yangtze river dolphin).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Whippomorpha; Cetacea; Odontoceti;
OC Lipotidae; Lipotes.
OX NCBI_TaxID=118797 {ECO:0000313|Proteomes:UP000265300, ECO:0000313|RefSeq:XP_007448361.1};
RN [1] {ECO:0000313|RefSeq:XP_007448361.1}
RP IDENTIFICATION.
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Lysosome {ECO:0000256|ARBA:ARBA00004371}.
CC -!- SIMILARITY: Belongs to the peptidase C1 family.
CC {ECO:0000256|ARBA:ARBA00008455}.
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DR RefSeq; XP_007448361.1; XM_007448299.1.
DR AlphaFoldDB; A0A340WI14; -.
DR STRING; 118797.A0A340WI14; -.
DR GeneID; 103089492; -.
DR KEGG; lve:103089492; -.
DR InParanoid; A0A340WI14; -.
DR OrthoDB; 5472948at2759; -.
DR Proteomes; UP000265300; Unplaced.
DR GO; GO:0005764; C:lysosome; IEA:UniProtKB-SubCell.
DR GO; GO:0008234; F:cysteine-type peptidase activity; IEA:UniProtKB-KW.
DR GO; GO:0006508; P:proteolysis; IEA:UniProtKB-KW.
DR CDD; cd02248; Peptidase_C1A; 1.
DR Gene3D; 3.90.70.10; Cysteine proteinases; 1.
DR InterPro; IPR038765; Papain-like_cys_pep_sf.
DR InterPro; IPR025661; Pept_asp_AS.
DR InterPro; IPR000169; Pept_cys_AS.
DR InterPro; IPR025660; Pept_his_AS.
DR InterPro; IPR013128; Peptidase_C1A.
DR InterPro; IPR000668; Peptidase_C1A_C.
DR InterPro; IPR039417; Peptidase_C1A_papain-like.
DR InterPro; IPR013201; Prot_inhib_I29.
DR PANTHER; PTHR12411:SF57; CATHEPSIN L2; 1.
DR PANTHER; PTHR12411; CYSTEINE PROTEASE FAMILY C1-RELATED; 1.
DR Pfam; PF08246; Inhibitor_I29; 1.
DR Pfam; PF00112; Peptidase_C1; 1.
DR PRINTS; PR00705; PAPAIN.
DR SMART; SM00848; Inhibitor_I29; 1.
DR SMART; SM00645; Pept_C1; 1.
DR SUPFAM; SSF54001; Cysteine proteinases; 1.
DR PROSITE; PS00640; THIOL_PROTEASE_ASN; 1.
DR PROSITE; PS00139; THIOL_PROTEASE_CYS; 1.
DR PROSITE; PS00639; THIOL_PROTEASE_HIS; 1.
PE 3: Inferred from homology;
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Lysosome {ECO:0000256|ARBA:ARBA00023228};
KW Protease {ECO:0000256|ARBA:ARBA00022670};
KW Reference proteome {ECO:0000313|Proteomes:UP000265300};
KW Signal {ECO:0000256|SAM:SignalP};
KW Thiol protease {ECO:0000256|ARBA:ARBA00022807};
KW Zymogen {ECO:0000256|ARBA:ARBA00023145}.
FT SIGNAL 1..17
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 18..333
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5018671112"
FT DOMAIN 29..87
FT /note="Cathepsin propeptide inhibitor"
FT /evidence="ECO:0000259|SMART:SM00848"
FT DOMAIN 113..332
FT /note="Peptidase C1A papain C-terminal"
FT /evidence="ECO:0000259|SMART:SM00645"
SQ SEQUENCE 333 AA; 37152 MW; DCBEFAF88E9F137C CRC64;
MNPSLFLTAL CLGIASAAPK LDQKLDVPWY QWKATHGRLY GMDEGWRRAV WEKNMKMIDL
HNQEYSQGKH GFTMAMNAFG DMTSEEFKQV MNGFQNQKHK KGKVFHEPFF LEVPKSVDWT
KKGYVTPVKN QGQCGSCWAF SATGALEGQM FWKTGKLVSL SEQNLVDCSR PQGNEGCSGG
LMDNAFQYVK DNGGLDSEES YPYLGKETNS CKYKPECSAV NDTGFVDIPQ REKALMKAVA
TVGPISVAID AGHTSFQFYK SGIYYDSDCS SKDLDHGVLV VGYGFEGTDS NNNKFWIVKN
SWGPEWGWNG YIKMAKDKNN HCGIATAASY PIV
//
