ID A0A340WKH0_LIPVE Unreviewed; 421 AA.
AC A0A340WKH0;
DT 10-OCT-2018, integrated into UniProtKB/TrEMBL.
DT 10-OCT-2018, sequence version 1.
DT 27-MAR-2024, entry version 20.
DE SubName: Full=Short-chain dehydrogenase/reductase family 42E member 2-like {ECO:0000313|RefSeq:XP_007450068.1};
GN Name=SDR42E2 {ECO:0000313|RefSeq:XP_007450068.1};
OS Lipotes vexillifer (Yangtze river dolphin).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Whippomorpha; Cetacea; Odontoceti;
OC Lipotidae; Lipotes.
OX NCBI_TaxID=118797 {ECO:0000313|Proteomes:UP000265300, ECO:0000313|RefSeq:XP_007450068.1};
RN [1] {ECO:0000313|RefSeq:XP_007450068.1}
RP IDENTIFICATION.
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the 3-beta-HSD family.
CC {ECO:0000256|ARBA:ARBA00009219}.
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DR RefSeq; XP_007450068.1; XM_007450006.1.
DR AlphaFoldDB; A0A340WKH0; -.
DR STRING; 118797.A0A340WKH0; -.
DR GeneID; 103071712; -.
DR KEGG; lve:103071712; -.
DR CTD; 100288072; -.
DR InParanoid; A0A340WKH0; -.
DR OrthoDB; 5487986at2759; -.
DR Proteomes; UP000265300; Unplaced.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0003854; F:3-beta-hydroxy-delta5-steroid dehydrogenase activity; IEA:InterPro.
DR GO; GO:0006694; P:steroid biosynthetic process; IEA:InterPro.
DR Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 1.
DR InterPro; IPR002225; 3Beta_OHSteriod_DH/Estase.
DR InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR PANTHER; PTHR43245; BIFUNCTIONAL POLYMYXIN RESISTANCE PROTEIN ARNA; 1.
DR PANTHER; PTHR43245:SF51; SHORT CHAIN DEHYDROGENASE_REDUCTASE FAMILY 42E, MEMBER 2; 1.
DR Pfam; PF01073; 3Beta_HSD; 1.
DR SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 1.
PE 3: Inferred from homology;
KW Membrane {ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000265300};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 393..414
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 41..305
FT /note="3-beta hydroxysteroid dehydrogenase/isomerase"
FT /evidence="ECO:0000259|Pfam:PF01073"
SQ SEQUENCE 421 AA; 46028 MW; 87BC7B2FD938A5C2 CRC64;
MKPNLAGSSP EACKAAGQAP VPVLQQKTQA TPVQASKQKV LVTGGGGYLG FSLGSSLAKS
GTSVILLDLR RPQWVLCPGT EFIQADVRDA EALHRAFEGV DCVFHMASCG MSGAEQLQKE
QIESINVGGT KLVIDVCVHR RVPRLVYTST VNVAFGGKPI EQGDEDSVPY FPLEKHVDHY
SRTKAIADQL ILMANGTPLP GGGALRTCVL RPPGIYGPEE QRHLPRVASH IKKRLFMFRF
GDRRTRMNWV HVCNLVQAHV LAAEALTATK GYVASGQAYY INDGESVNLF EWMAPLFEKL
GYSKPWIQVP TSWVYLSATV MEYLHLALKP ICSLPPLLTR SEVRSVAVTH TFQIAKARAQ
LGYVPDKFSF ADAVERYVQS TGQGTRGSTA RTLLRLLLGL LLLLGLLVLA LHFLGPRPFV
V
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