ID   A0A340WMQ1_LIPVE        Unreviewed;       865 AA.
AC   A0A340WMQ1;
DT   10-OCT-2018, integrated into UniProtKB/TrEMBL.
DT   10-OCT-2018, sequence version 1.
DT   27-MAR-2024, entry version 28.
DE   SubName: Full=Mismatch repair endonuclease PMS2 {ECO:0000313|RefSeq:XP_007448937.1};
GN   Name=PMS2 {ECO:0000313|RefSeq:XP_007448937.1};
OS   Lipotes vexillifer (Yangtze river dolphin).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Whippomorpha; Cetacea; Odontoceti;
OC   Lipotidae; Lipotes.
OX   NCBI_TaxID=118797 {ECO:0000313|Proteomes:UP000265300, ECO:0000313|RefSeq:XP_007448937.1};
RN   [1] {ECO:0000313|RefSeq:XP_007448937.1}
RP   IDENTIFICATION.
RG   RefSeq;
RL   Submitted (NOV-2023) to UniProtKB.
CC   -!- SIMILARITY: Belongs to the DNA mismatch repair MutL/HexB family.
CC       {ECO:0000256|ARBA:ARBA00006082}.
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DR   RefSeq; XP_007448937.1; XM_007448875.1.
DR   AlphaFoldDB; A0A340WMQ1; -.
DR   STRING; 118797.A0A340WMQ1; -.
DR   GeneID; 103073080; -.
DR   KEGG; lve:103073080; -.
DR   CTD; 5395; -.
DR   InParanoid; A0A340WMQ1; -.
DR   OrthoDB; 4698638at2759; -.
DR   Proteomes; UP000265300; Unplaced.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProt.
DR   GO; GO:0032300; C:mismatch repair complex; IEA:InterPro.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-KW.
DR   GO; GO:0005524; F:ATP binding; IEA:InterPro.
DR   GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR   GO; GO:0140664; F:ATP-dependent DNA damage sensor activity; IEA:InterPro.
DR   GO; GO:0004519; F:endonuclease activity; IEA:UniProtKB-KW.
DR   GO; GO:0030983; F:mismatched DNA binding; IEA:InterPro.
DR   GO; GO:0006298; P:mismatch repair; IEA:InterPro.
DR   CDD; cd16926; HATPase_MutL-MLH-PMS-like; 1.
DR   CDD; cd03484; MutL_Trans_hPMS_2_like; 1.
DR   Gene3D; 3.30.230.10; -; 1.
DR   Gene3D; 3.30.565.10; Histidine kinase-like ATPase, C-terminal domain; 1.
DR   Gene3D; 3.30.1540.20; MutL, C-terminal domain, dimerisation subdomain; 1.
DR   Gene3D; 3.30.1370.100; MutL, C-terminal domain, regulatory subdomain; 1.
DR   InterPro; IPR014762; DNA_mismatch_repair_CS.
DR   InterPro; IPR013507; DNA_mismatch_S5_2-like.
DR   InterPro; IPR036890; HATPase_C_sf.
DR   InterPro; IPR002099; MutL/Mlh/PMS.
DR   InterPro; IPR038973; MutL/Mlh/Pms-like.
DR   InterPro; IPR014790; MutL_C.
DR   InterPro; IPR042120; MutL_C_dimsub.
DR   InterPro; IPR042121; MutL_C_regsub.
DR   InterPro; IPR037198; MutL_C_sf.
DR   InterPro; IPR020568; Ribosomal_Su5_D2-typ_SF.
DR   InterPro; IPR014721; Ribsml_uS5_D2-typ_fold_subgr.
DR   NCBIfam; TIGR00585; mutl; 1.
DR   PANTHER; PTHR10073; DNA MISMATCH REPAIR PROTEIN MLH, PMS, MUTL; 1.
DR   PANTHER; PTHR10073:SF52; MISMATCH REPAIR ENDONUCLEASE PMS2; 1.
DR   Pfam; PF01119; DNA_mis_repair; 1.
DR   Pfam; PF13589; HATPase_c_3; 1.
DR   Pfam; PF08676; MutL_C; 1.
DR   SMART; SM01340; DNA_mis_repair; 1.
DR   SMART; SM00853; MutL_C; 1.
DR   SUPFAM; SSF55874; ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase; 1.
DR   SUPFAM; SSF118116; DNA mismatch repair protein MutL; 1.
DR   SUPFAM; SSF54211; Ribosomal protein S5 domain 2-like; 1.
DR   PROSITE; PS00058; DNA_MISMATCH_REPAIR_1; 1.
PE   3: Inferred from homology;
KW   DNA damage {ECO:0000256|ARBA:ARBA00022763};
KW   Endonuclease {ECO:0000313|RefSeq:XP_007448937.1};
KW   Hydrolase {ECO:0000313|RefSeq:XP_007448937.1};
KW   Nuclease {ECO:0000313|RefSeq:XP_007448937.1};
KW   Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW   Reference proteome {ECO:0000313|Proteomes:UP000265300}.
FT   DOMAIN          227..364
FT                   /note="DNA mismatch repair protein S5"
FT                   /evidence="ECO:0000259|SMART:SM01340"
FT   DOMAIN          681..825
FT                   /note="MutL C-terminal dimerisation"
FT                   /evidence="ECO:0000259|SMART:SM00853"
FT   REGION          389..415
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          427..535
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        446..465
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        498..533
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   865 AA;  96241 MW;  0551B3AACC6F459A CRC64;
     MERADAPCSE LAKAIKPIDR KSVHQICSGQ VVLSLSTAVK ELVENSVDAS ATNIELRLKD
     YGAELIEVSD NGCGVEEDNF EGLTLKHHTS KIQEFADLTQ VETFGFRGEA LSSLCALSDV
     TISTCHTSAK VGTRLVFDHN GKILQKTPYP RPRGTTVSVQ QLFYTLPVRH KEFQRNIKKE
     FSKMVQVLHA YCIISAGVRV SCTNQVGQGK RQPVVCTSGG SSMKENIGSV FGQKQLQSLI
     PFVQLPPSDT VREEYGLSSS QALHNLFCIS GFISHCAHGA GRSSTDRQFF FINRRPCDPA
     KVSRLVNEVY HMYNRHQYPF VVLNISVDME CVDINVTPDK RQILLQEEKL LLAVLKTSLI
     GMFDSDVNKL NVSQQPLFDV EGHLIKRHSA EVEKPVPGKQ DDPAPLRTRG EEKRAATISR
     LREAFSLRHA VEDKSRGPKA TAPRRISPRQ RSSTPFPSAS GPLCSWNHIS EPREEGVTST
     QGPCDPMGRV DTEEGWGHSS ASAGSEEGSS TPKTGSQPSS DHVASSPKDG FSQENVESLE
     KLPETDHRLL GTNCHLDHEE SGSRPRVLLQ STHLSSPNAK RFKKEGVPLN PDVLPESMKT
     QNASACEVDV AVEINKKIVP LDFSMSSLAK RIKQLCQQEQ QQEGGQNYRK FRAKICPGEN
     QAAEDELRKE ISKTMFAEME IIGQFNLGFI ITKLNADIFI VDQHATDEKY NFEMLQQHTV
     LQGQRLIAPQ TLNLTAVNEA ILIENLEIFR KNGFDFVIDE DAPVTERAKL ISLPTSKSWT
     FGPQDIDELI FMLSDSPGVM CRPSRVRQMF ASRACRKSVM IGTALNTSEM KKLITHMGEM
     DRPWNCPHGR PTMRHIANLD IISQN
//