ID A0A340WP75_LIPVE Unreviewed; 838 AA.
AC A0A340WP75;
DT 10-OCT-2018, integrated into UniProtKB/TrEMBL.
DT 10-OCT-2018, sequence version 1.
DT 27-MAR-2024, entry version 24.
DE SubName: Full=Stromal interaction molecule 2 isoform X1 {ECO:0000313|RefSeq:XP_007448874.1};
GN Name=STIM2 {ECO:0000313|RefSeq:XP_007448874.1};
OS Lipotes vexillifer (Yangtze river dolphin).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Whippomorpha; Cetacea; Odontoceti;
OC Lipotidae; Lipotes.
OX NCBI_TaxID=118797 {ECO:0000313|Proteomes:UP000265300, ECO:0000313|RefSeq:XP_007448874.1};
RN [1] {ECO:0000313|RefSeq:XP_007448874.1}
RP IDENTIFICATION.
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004479}; Single-
CC pass type I membrane protein {ECO:0000256|ARBA:ARBA00004479}.
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DR RefSeq; XP_007448874.1; XM_007448812.1.
DR AlphaFoldDB; A0A340WP75; -.
DR STRING; 118797.A0A340WP75; -.
DR GeneID; 103078894; -.
DR KEGG; lve:103078894; -.
DR CTD; 57620; -.
DR InParanoid; A0A340WP75; -.
DR OrthoDB; 54068at2759; -.
DR Proteomes; UP000265300; Unplaced.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005246; F:calcium channel regulator activity; IEA:InterPro.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0006816; P:calcium ion transport; IEA:UniProtKB-KW.
DR GO; GO:0006874; P:intracellular calcium ion homeostasis; IEA:InterPro.
DR GO; GO:0051049; P:regulation of transport; IEA:UniProt.
DR CDD; cd09574; SAM_STIM2; 1.
DR CDD; cd11722; SOAR; 1.
DR Gene3D; 1.10.238.180; -; 1.
DR Gene3D; 1.10.287.3550; -; 1.
DR Gene3D; 1.20.5.340; -; 1.
DR Gene3D; 1.10.150.50; Transcription Factor, Ets-1; 1.
DR InterPro; IPR001660; SAM.
DR InterPro; IPR013761; SAM/pointed_sf.
DR InterPro; IPR032393; SOAR.
DR InterPro; IPR037608; STIM.
DR InterPro; IPR037610; STIM2_SAM.
DR PANTHER; PTHR15136:SF2; STROMAL INTERACTION MOLECULE 2; 1.
DR PANTHER; PTHR15136; STROMAL INTERACTION MOLECULE HOMOLOG; 1.
DR Pfam; PF07647; SAM_2; 1.
DR Pfam; PF16533; SOAR; 1.
DR SUPFAM; SSF47769; SAM/Pointed domain; 1.
DR PROSITE; PS50105; SAM_DOMAIN; 1.
PE 4: Predicted;
KW Calcium {ECO:0000256|ARBA:ARBA00022837};
KW Calcium transport {ECO:0000256|ARBA:ARBA00022568};
KW Coiled coil {ECO:0000256|ARBA:ARBA00023054, ECO:0000256|SAM:Coils};
KW Ion transport {ECO:0000256|ARBA:ARBA00023065};
KW Membrane {ECO:0000256|ARBA:ARBA00023136};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Reference proteome {ECO:0000313|Proteomes:UP000265300};
KW Signal {ECO:0000256|ARBA:ARBA00022729};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989};
KW Transport {ECO:0000256|ARBA:ARBA00022448}.
FT DOMAIN 221..279
FT /note="SAM"
FT /evidence="ECO:0000259|PROSITE:PS50105"
FT REGION 1..75
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 609..654
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 717..739
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 782..838
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 337..374
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 16..41
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 55..70
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 609..623
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 782..798
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 838 AA; 93629 MW; CD42584D284560E7 CRC64;
MNAAGTRAPE AAGADGTRLE PDRSSRLRRR GRPEESQEAA APREAGEWLA AGAPPRFPSA
PPPRPHPATT PGPASGWLRR RRWAALLVLG LLVAGAADGC ELVPRHLRGR RTAGSAAAAA
SSPAAAGGDS PALMTDPCMS LSPPCFTEED RFSLEALQTI HKQMDDDKDG GIEVDESDEF
IREDMKYKDA TNKHSHLHRE DKHITVEDLW KRWKTSEVHN WTLEDTLQWL IEFVELPQYE
KNFRDNNVKG TTLPRIAVHE PSFMISQLKI SDRSHRQKLQ LKALDVVLFG PLTRPPHNWM
KDFILTVSIV IGVGGCWFAY TQNRTSKEHV AKMMKDLESL QTAEQSLMDL QERLEKAQEE
NRNVAVEKQN LERKMMDEIN YAKEEACRLR ELREGAECEL SRRQYAEQEL EQVRMALKKA
EKEFELRSSW SVPDALQKWL QLTHEVEVQY YNIKRQNAEM QLAIAKDEVA ASYLIQAEKI
KKKRSTVFGT LHVAHSSSLD EVDHKILEAK KALSELTTCL RERLFRWQQI EKICGFQIAH
NSGLPSLTSS LYSDHSWVVM PRVSIPPYPI AGGVDDLDED TPPIVSQFPG TMAKPAGSLA
RSSSLCRSRR SIVPSSPQSQ RAQLPAHAHP AHPRHPHHPQ HTQHSLPSPD PDILSVSSCP
ALYRNEEEEE AIYFSAEKQW EVPDTASECD SLNSSIGRKQ SPPSSLEIYQ TLSPRKISRD
ELSLEDSSRG ESPIAADISR GSPNCVGLTE TKSMIFSPAS KVYNGILEKS CSMNQLSSGI
PVPKPRHTSC SSAGNDSKPV QEAPGVARIS SIPHDLCHNG EKSKKPSKIK SLFKKKSK
//
