ID A0A340WQP3_LIPVE Unreviewed; 433 AA.
AC A0A340WQP3;
DT 10-OCT-2018, integrated into UniProtKB/TrEMBL.
DT 10-OCT-2018, sequence version 1.
DT 27-MAR-2024, entry version 21.
DE RecName: Full=Chimaerin {ECO:0000256|PIRNR:PIRNR038015};
DE AltName: Full=Chimerin {ECO:0000256|PIRNR:PIRNR038015};
GN Name=CHN1 {ECO:0000313|RefSeq:XP_007451136.1};
OS Lipotes vexillifer (Yangtze river dolphin).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Whippomorpha; Cetacea; Odontoceti;
OC Lipotidae; Lipotes.
OX NCBI_TaxID=118797 {ECO:0000313|Proteomes:UP000265300, ECO:0000313|RefSeq:XP_007451136.1};
RN [1] {ECO:0000313|RefSeq:XP_007451136.1}
RP IDENTIFICATION.
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- FUNCTION: GTPase-activating protein for p21-rac.
CC {ECO:0000256|PIRNR:PIRNR038015}.
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DR RefSeq; XP_007451136.1; XM_007451074.1.
DR AlphaFoldDB; A0A340WQP3; -.
DR GeneID; 103088438; -.
DR CTD; 1123; -.
DR OrthoDB; 5395569at2759; -.
DR Proteomes; UP000265300; Unplaced.
DR GO; GO:0005096; F:GTPase activator activity; IEA:UniProtKB-UniRule.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-UniRule.
DR GO; GO:0051056; P:regulation of small GTPase mediated signal transduction; IEA:UniProtKB-UniRule.
DR GO; GO:0007165; P:signal transduction; IEA:InterPro.
DR CDD; cd20806; C1_CHN; 1.
DR CDD; cd04372; RhoGAP_chimaerin; 1.
DR CDD; cd10352; SH2_a2chimerin_b2chimerin; 1.
DR Gene3D; 3.30.60.20; -; 1.
DR Gene3D; 1.10.555.10; Rho GTPase activation protein; 1.
DR Gene3D; 3.30.505.10; SH2 domain; 1.
DR InterPro; IPR046349; C1-like_sf.
DR InterPro; IPR035840; Chimaerin_SH2.
DR InterPro; IPR017356; CHN1/CHN2.
DR InterPro; IPR020454; DAG/PE-bd.
DR InterPro; IPR002219; PE/DAG-bd.
DR InterPro; IPR008936; Rho_GTPase_activation_prot.
DR InterPro; IPR037860; RhoGAP_chimaerin.
DR InterPro; IPR000198; RhoGAP_dom.
DR InterPro; IPR000980; SH2.
DR InterPro; IPR036860; SH2_dom_sf.
DR PANTHER; PTHR46075; CHIMERIN FAMILY MEMBER; 1.
DR PANTHER; PTHR46075:SF1; N-CHIMAERIN; 1.
DR Pfam; PF00130; C1_1; 1.
DR Pfam; PF00620; RhoGAP; 1.
DR Pfam; PF00017; SH2; 1.
DR PIRSF; PIRSF038015; N-chimaerin; 2.
DR PRINTS; PR00008; DAGPEDOMAIN.
DR SMART; SM00109; C1; 1.
DR SMART; SM00324; RhoGAP; 1.
DR SMART; SM00252; SH2; 1.
DR SUPFAM; SSF57889; Cysteine-rich domain; 1.
DR SUPFAM; SSF48350; GTPase activation domain, GAP; 1.
DR SUPFAM; SSF55550; SH2 domain; 1.
DR PROSITE; PS50238; RHOGAP; 1.
DR PROSITE; PS50001; SH2; 1.
DR PROSITE; PS50081; ZF_DAG_PE_2; 1.
PE 4: Predicted;
KW GTPase activation {ECO:0000256|PIRNR:PIRNR038015};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723,
KW ECO:0000256|PIRNR:PIRNR038015};
KW Reference proteome {ECO:0000313|Proteomes:UP000265300};
KW SH2 domain {ECO:0000256|PROSITE-ProRule:PRU00191};
KW Zinc {ECO:0000256|ARBA:ARBA00022833}.
FT DOMAIN 49..117
FT /note="SH2"
FT /evidence="ECO:0000259|PROSITE:PS50001"
FT DOMAIN 184..229
FT /note="Phorbol-ester/DAG-type"
FT /evidence="ECO:0000259|PROSITE:PS50081"
FT DOMAIN 242..433
FT /note="Rho-GAP"
FT /evidence="ECO:0000259|PROSITE:PS50238"
SQ SEQUENCE 433 AA; 50018 MW; 926A37B280759046 CRC64;
MALTLFDTDE YRPPVWKSYL YQLQQEAPHP RRITCTNEVE NRPKYYGREF HGMISREAAD
QLLSVAEGSY LIRESQRQPG TYTLALRFGS QTRNFRLYYD GKHFVGEKRF ESIHDLVTDG
LITLYIETKA AEYIAKMTIN PIYEHIGYTT LNREPAYQKH MPIPKETLDE KDSTGQDGVS
EKRVHTFRGP HWCEYCANFM WGLIAQGVRC ADCGLNVHKQ CSKMVPNDCK PDLKHVKKVY
SCDLTTLVKA HITKRPMVVD MCIREIESRG LNSEGLYRVS GFSDLIEDVK MAFDRDGEKA
DISVNMYEDI NIITGALKLY FRDLPIPLIT YDAYPKFIES AKIMDPDEQL ETLHEALKLL
PPAHCETLRY LMAHLKRVTL HEKENLMNAE NLGIVFGPTL MRSPELDAMA ALNDIRYQRL
VVELLIKNED ILF
//
