ID   A0A340WSI9_LIPVE        Unreviewed;       790 AA.
AC   A0A340WSI9;
DT   10-OCT-2018, integrated into UniProtKB/TrEMBL.
DT   10-OCT-2018, sequence version 1.
DT   27-MAR-2024, entry version 22.
DE   SubName: Full=Pleckstrin homology domain-containing family H member 3 {ECO:0000313|RefSeq:XP_007449920.1};
GN   Name=PLEKHH3 {ECO:0000313|RefSeq:XP_007449920.1};
OS   Lipotes vexillifer (Yangtze river dolphin).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Whippomorpha; Cetacea; Odontoceti;
OC   Lipotidae; Lipotes.
OX   NCBI_TaxID=118797 {ECO:0000313|Proteomes:UP000265300, ECO:0000313|RefSeq:XP_007449920.1};
RN   [1] {ECO:0000313|RefSeq:XP_007449920.1}
RP   IDENTIFICATION.
RG   RefSeq;
RL   Submitted (NOV-2023) to UniProtKB.
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DR   RefSeq; XP_007449920.1; XM_007449858.1.
DR   AlphaFoldDB; A0A340WSI9; -.
DR   STRING; 118797.A0A340WSI9; -.
DR   GeneID; 103072545; -.
DR   KEGG; lve:103072545; -.
DR   CTD; 79990; -.
DR   InParanoid; A0A340WSI9; -.
DR   OrthoDB; 5350290at2759; -.
DR   Proteomes; UP000265300; Unplaced.
DR   GO; GO:0005856; C:cytoskeleton; IEA:InterPro.
DR   GO; GO:0007165; P:signal transduction; IEA:InterPro.
DR   CDD; cd13297; PH3_MyoX-like; 1.
DR   Gene3D; 1.20.80.10; -; 1.
DR   Gene3D; 1.25.40.530; MyTH4 domain; 1.
DR   Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 2.
DR   InterPro; IPR019749; Band_41_domain.
DR   InterPro; IPR014352; FERM/acyl-CoA-bd_prot_sf.
DR   InterPro; IPR000299; FERM_domain.
DR   InterPro; IPR000857; MyTH4_dom.
DR   InterPro; IPR038185; MyTH4_dom_sf.
DR   InterPro; IPR011993; PH-like_dom_sf.
DR   InterPro; IPR001849; PH_domain.
DR   InterPro; IPR000159; RA_dom.
DR   PANTHER; PTHR46049; AGAP003327-PA; 1.
DR   PANTHER; PTHR46049:SF5; PLECKSTRIN HOMOLOGY DOMAIN-CONTAINING FAMILY H MEMBER 3; 1.
DR   Pfam; PF00784; MyTH4; 1.
DR   Pfam; PF00788; RA; 1.
DR   SMART; SM00295; B41; 1.
DR   SMART; SM00139; MyTH4; 1.
DR   SMART; SM00233; PH; 1.
DR   SUPFAM; SSF50729; PH domain-like; 1.
DR   PROSITE; PS50057; FERM_3; 1.
DR   PROSITE; PS51016; MYTH4; 1.
DR   PROSITE; PS50003; PH_DOMAIN; 1.
PE   4: Predicted;
KW   Reference proteome {ECO:0000313|Proteomes:UP000265300};
KW   Signal {ECO:0000256|SAM:SignalP}.
FT   SIGNAL          1..18
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT   CHAIN           19..790
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT                   /id="PRO_5016305278"
FT   DOMAIN          95..199
FT                   /note="PH"
FT                   /evidence="ECO:0000259|PROSITE:PS50003"
FT   DOMAIN          237..399
FT                   /note="MyTH4"
FT                   /evidence="ECO:0000259|PROSITE:PS51016"
FT   DOMAIN          404..754
FT                   /note="FERM"
FT                   /evidence="ECO:0000259|PROSITE:PS50057"
FT   REGION          28..74
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          555..578
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          748..790
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        758..790
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   790 AA;  85014 MW;  30F9DFF37FD9D66A CRC64;
     MPLPGGLWWL LCCRRGFTLL HRDYGDGELS GDGDEDEDEE TFELRTPSPA GGGRGPLDVT
     LTQPVRSGPV SDRLQSWEET RSLIPEKGPS EDDPDVVVKG WLYREPRGGG ARPWLPPRRA
     WFVLTRDSLD QFSSSGKGAR RLGSLVLTSL CSVTGPERRP KETGLWSVTV SGRKHSVRLC
     SPRQAEAERW GVALREVIAS KAPLETPTQL LLRDIQESCG DPEAVALIYR RNPILRHTSG
     ALYAPLLPLP YGVNAPGPGY APLREEAVRL FLALQALEGA RRPGPLMQGV LQTCRDLPAL
     RDELFLQLAK QTSGPAGPPG PPATQDPAAL RYWQLLTCMS CTFRPGGPVR GHLLGHLERT
     EQALPDSELA EYARFIRKAL GQTRGRELVP SLAEISALSR RQELLCTVHC PGAGACPVAI
     DSHTTAGEVA RELVGRLGLT RSRNAFALYE QRGAQERALA GGTLVADVLT RFENLAAEEA
     GLEDPPDSGW RLCLRLHGPL HPEGLSPDGH ELPFLFEQAQ ALLLRGRPSP PDDTLRAQAA
     LRLRSLHRDF SPRAPLQRLD RLLPTPAPPR EDPLRPVPRP PRSAALLAGA IWSPALAKRR
     AERARRGGAG RTAGSVAREG GGGAGTAAAV LGGWKRLRGM GRAEAMAAYL ALAAQCPGFG
     AARYDVLELS TEPGGGAPQK LCLGLGAKAM SLSRPGETQP VHSVSYGRVA ACQLMGPHTL
     ALRVGESQLL LQSPQVEEIV QLVNAYLASP ERPSSSPPPC QDLTDTSPPS QYPGLDEPQG
     QSGCLGQLQD
//