ID A0A340WTH0_LIPVE Unreviewed; 673 AA.
AC A0A340WTH0;
DT 10-OCT-2018, integrated into UniProtKB/TrEMBL.
DT 10-OCT-2018, sequence version 1.
DT 27-MAR-2024, entry version 26.
DE RecName: Full=Kinesin-like protein {ECO:0000256|RuleBase:RU000394};
GN Name=KIF22 {ECO:0000313|RefSeq:XP_007452803.1};
OS Lipotes vexillifer (Yangtze river dolphin).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Whippomorpha; Cetacea; Odontoceti;
OC Lipotidae; Lipotes.
OX NCBI_TaxID=118797 {ECO:0000313|Proteomes:UP000265300, ECO:0000313|RefSeq:XP_007452803.1};
RN [1] {ECO:0000313|RefSeq:XP_007452803.1}
RP IDENTIFICATION.
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the TRAFAC class myosin-kinesin ATPase
CC superfamily. Kinesin family. {ECO:0000256|PROSITE-ProRule:PRU00283,
CC ECO:0000256|RuleBase:RU000394}.
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DR RefSeq; XP_007452803.1; XM_007452741.1.
DR AlphaFoldDB; A0A340WTH0; -.
DR STRING; 118797.A0A340WTH0; -.
DR GeneID; 103089952; -.
DR KEGG; lve:103089952; -.
DR CTD; 3835; -.
DR InParanoid; A0A340WTH0; -.
DR OrthoDB; 129693at2759; -.
DR Proteomes; UP000265300; Unplaced.
DR GO; GO:0005874; C:microtubule; IEA:UniProtKB-KW.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR GO; GO:0008017; F:microtubule binding; IEA:InterPro.
DR GO; GO:0003777; F:microtubule motor activity; IEA:InterPro.
DR GO; GO:0006281; P:DNA repair; IEA:InterPro.
DR GO; GO:0007018; P:microtubule-based movement; IEA:InterPro.
DR CDD; cd01376; KISc_KID_like; 1.
DR Gene3D; 1.10.150.280; AF1531-like domain; 1.
DR Gene3D; 3.40.850.10; Kinesin motor domain; 1.
DR InterPro; IPR003583; Hlx-hairpin-Hlx_DNA-bd_motif.
DR InterPro; IPR027640; Kinesin-like_fam.
DR InterPro; IPR019821; Kinesin_motor_CS.
DR InterPro; IPR001752; Kinesin_motor_dom.
DR InterPro; IPR036961; Kinesin_motor_dom_sf.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR010994; RuvA_2-like.
DR PANTHER; PTHR24115:SF1000; KINESIN-LIKE PROTEIN KIF22; 1.
DR PANTHER; PTHR24115; KINESIN-RELATED; 1.
DR Pfam; PF12836; HHH_3; 1.
DR Pfam; PF00225; Kinesin; 1.
DR PRINTS; PR00380; KINESINHEAVY.
DR SMART; SM00278; HhH1; 2.
DR SMART; SM00129; KISc; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR SUPFAM; SSF47781; RuvA domain 2-like; 1.
DR PROSITE; PS00411; KINESIN_MOTOR_1; 1.
DR PROSITE; PS50067; KINESIN_MOTOR_2; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|PROSITE-
KW ProRule:PRU00283}; Coiled coil {ECO:0000256|SAM:Coils};
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Cytoskeleton {ECO:0000256|ARBA:ARBA00023212};
KW Isopeptide bond {ECO:0000256|ARBA:ARBA00022499};
KW Microtubule {ECO:0000256|RuleBase:RU000394};
KW Motor protein {ECO:0000256|PROSITE-ProRule:PRU00283,
KW ECO:0000256|RuleBase:RU000394};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741, ECO:0000256|PROSITE-
KW ProRule:PRU00283}; Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Reference proteome {ECO:0000313|Proteomes:UP000265300};
KW Ubl conjugation {ECO:0000256|ARBA:ARBA00022843}.
FT DOMAIN 48..373
FT /note="Kinesin motor"
FT /evidence="ECO:0000259|PROSITE:PS50067"
FT REGION 399..432
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 480..507
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 399..415
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT BINDING 132..139
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00283"
SQ SEQUENCE 673 AA; 74734 MW; B04721BDEDEAAF2A CRC64;
MERRAQGRSR MDVGVPARRR REMAAVTSGA GRCRLSKVGA GRRPPPARVR VAVRLRPFVD
GAAGENDTPC VRGLDSCSLE IANWRNHQET LKYQFDAFYG ERSSQQDIYA GSVQPILRHL
LEGQNASVLA YGPTGAGKTH TMLGSPEQPG VIPRALMDLL QLTREESAEG RPWALSVTMS
YLEIYQEKVL DLLEPSSGDL VIREDCRGNI LIPGLTQKPI TSFADFERHF LPASRNRTVG
ATRLNQRSSR SHAVLLVKVD QRERLAPFRQ REGKLYLIDL AGSEDNRRTG NKGLRLKESG
AINTSLFVLG KVVDALNQGL PRVPYRDSKL TRLLQDSLGG SAHSILIANI APERRFYLDT
VSALNFAARS KEVINRPFTN ESLQLHVLAP IKLSKKELLG PSEAKRARGP EEEETGSPEP
PAAPSSASQK LSPLQKLNSM DPAMVERLLS LDRLLGSQGS QGTPLLSTPR RERMVLMKTV
EAKDLEIERL KMKQKELEAK VLAQEAADPK EKENYSPTML RPLARRTVTV AKPLKKAVVM
PLQLIQEQAA YPNAEIHILK KKGRKRKLES LDASELEEKG EDCWELQISP ELLAHGRQKI
LDLLNEGSAR DLRSLQRIGQ KKAQLIVGWR ELHGPFSQVE DLERVEGISG KQMESFLKAN
ILGLAAGQRC GPS
//
