ID A0A340WTZ4_LIPVE Unreviewed; 1190 AA.
AC A0A340WTZ4;
DT 10-OCT-2018, integrated into UniProtKB/TrEMBL.
DT 10-OCT-2018, sequence version 1.
DT 27-MAR-2024, entry version 24.
DE SubName: Full=Roundabout homolog 2-like isoform X3 {ECO:0000313|RefSeq:XP_007450355.1};
GN Name=ROBO2 {ECO:0000313|RefSeq:XP_007450355.1};
OS Lipotes vexillifer (Yangtze river dolphin).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Whippomorpha; Cetacea; Odontoceti;
OC Lipotidae; Lipotes.
OX NCBI_TaxID=118797 {ECO:0000313|Proteomes:UP000265300, ECO:0000313|RefSeq:XP_007450355.1};
RN [1] {ECO:0000313|RefSeq:XP_007450355.1}
RP IDENTIFICATION.
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
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DR RefSeq; XP_007450355.1; XM_007450293.1.
DR AlphaFoldDB; A0A340WTZ4; -.
DR GeneID; 103073565; -.
DR CTD; 6092; -.
DR OrthoDB; 5396194at2759; -.
DR Proteomes; UP000265300; Unplaced.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR CDD; cd00063; FN3; 3.
DR CDD; cd05726; IgI_4_Robo; 1.
DR CDD; cd20952; IgI_5_Robo; 1.
DR Gene3D; 2.60.40.10; Immunoglobulins; 7.
DR InterPro; IPR003961; FN3_dom.
DR InterPro; IPR036116; FN3_sf.
DR InterPro; IPR007110; Ig-like_dom.
DR InterPro; IPR036179; Ig-like_dom_sf.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR013098; Ig_I-set.
DR InterPro; IPR003599; Ig_sub.
DR InterPro; IPR003598; Ig_sub2.
DR InterPro; IPR013106; Ig_V-set.
DR PANTHER; PTHR44170; PROTEIN SIDEKICK; 1.
DR PANTHER; PTHR44170:SF52; ROUNDABOUT HOMOLOG 2; 1.
DR Pfam; PF00041; fn3; 3.
DR Pfam; PF07679; I-set; 2.
DR Pfam; PF13927; Ig_3; 1.
DR SMART; SM00060; FN3; 3.
DR SMART; SM00409; IG; 3.
DR SMART; SM00408; IGc2; 3.
DR SMART; SM00406; IGv; 3.
DR SUPFAM; SSF49265; Fibronectin type III; 2.
DR SUPFAM; SSF48726; Immunoglobulin; 4.
DR PROSITE; PS50853; FN3; 3.
DR PROSITE; PS50835; IG_LIKE; 3.
PE 4: Predicted;
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Immunoglobulin domain {ECO:0000256|ARBA:ARBA00023319};
KW Membrane {ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000265300};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 672..694
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 37..121
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 126..221
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 229..316
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 336..430
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 449..546
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 551..648
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT REGION 844..891
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 936..968
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1023..1190
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 953..968
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1025..1039
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1050..1096
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1104..1125
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1136..1153
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1175..1190
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1190 AA; 129528 MW; F26DFC37C8CDE508 CRC64;
MISNTRKSDA GMYTCVGTNM VGERDSDPAE LTVFERPAFL RRPINQVVLE EEAVEFRCQV
QGDPQPTVRW KKDDADLPRG RYDIKDDYTL RIKKAMSTDE GTYMCIAENR VGKVEASATL
TVRAPPQFVV RPRDQIVAQG RTVTFPCETK GNPQPAVFWQ KEGSQNLLFP NQPQQANSRC
SVSPAGDLTI TDTQRSDAGY YICQALTVAG SILAKAQLEV TDVLTDRPPP IILQGPANQT
LAVDGTALLK CKATGDPLPV ISWLKEGFTF LGRDPRATIQ EQGTLQIKNL RISDTGTYTC
VATSSSGETS WSAVLDVTES GATISKNYDF NDLPGPPSKP QVTDVTKNSV TLSWQPGTPG
TLPASAYIIE AFSQSVSNSW QTVANHVKTT LYTVRGLRPN TIYLFMVRAI NPQGLSDPSA
MSDPVRTQDI SPPAQGVDHR QVQKELGDVL VHLHTPVVLT PTTVQVTWTV DRQPQFIQGY
RVMYRQTSGL QASSTWQNLD AKVPTERSAV LVNLKKGVTY EIKVRPYFNE FQGMDSESKT
VRTAEEAPSA PPQSVTVLTV GSHNSTSISV SWDPPPPDHQ NGIIQEYKIW CLGNETRFHI
NKTVDAAIRS VIIGGLFPGI QYRVEVAAST SAGVGVKSEP QPIIIGGRNE VVITENNNSI
TEQITDVVKQ PAFIAGIGGA CWVILMGFSI WLYWRRKKRK GLSNYAVTFQ RGDGGLMSNG
SRPGLLNAGD PSYPWLADSW PATSLPVNNS SSGPNEIANF GRGDVLPPVP GQGDKTATML
SDGAIYSSID FTTKTTYNSS SQITQTTPYA TTQILHSNSI HELAVDLPDP QWKSSIQQKT
DLMGFGYSLP DQNKGNNGGK GGKKKKNKNS SKAQKNNGST WANVPLPPPP VQPLPGTELE
HYAVELQENG YDSDSWCPPL PVQTYLHQGM EDELEEDDDR VPTPPVRGVA SSPAISFGQQ
STATLTPSPR EEMQPMLQAH LDELTRAYQF DIAKQTWHVQ SNNQPPQPPV PPLGYMSGAL
ISDLETDVPD DDADDEEEAL EIPRPLRALE QTPGSSTDNL DSSVTGKAFT SSQRPRPTSP
FSTDSNTSAA MSQSQRPRPT KKHKGGRVDP QPALPHRREG MTDEETLVPY SKPSFPSPGG
HSSSGTASSK GSTGPRKAEA LRGSHQRNAS DLLDIGYMGS NSQGQFTGEL
//
