ID A0A340WU27_LIPVE Unreviewed; 2603 AA.
AC A0A340WU27;
DT 10-OCT-2018, integrated into UniProtKB/TrEMBL.
DT 10-OCT-2018, sequence version 1.
DT 27-MAR-2024, entry version 28.
DE RecName: Full=DNA helicase {ECO:0000256|ARBA:ARBA00012551};
DE EC=3.6.4.12 {ECO:0000256|ARBA:ARBA00012551};
GN Name=POLQ {ECO:0000313|RefSeq:XP_007450569.1};
OS Lipotes vexillifer (Yangtze river dolphin).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Whippomorpha; Cetacea; Odontoceti;
OC Lipotidae; Lipotes.
OX NCBI_TaxID=118797 {ECO:0000313|Proteomes:UP000265300, ECO:0000313|RefSeq:XP_007450569.1};
RN [1] {ECO:0000313|RefSeq:XP_007450569.1}
RP IDENTIFICATION.
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + H2O = ADP + H(+) + phosphate; Xref=Rhea:RHEA:13065,
CC ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616,
CC ChEBI:CHEBI:43474, ChEBI:CHEBI:456216; EC=3.6.4.12;
CC Evidence={ECO:0000256|ARBA:ARBA00001665};
CC -!- CATALYTIC ACTIVITY:
CC Reaction=a 2'-deoxyribonucleoside 5'-triphosphate + DNA(n) =
CC diphosphate + DNA(n+1); Xref=Rhea:RHEA:22508, Rhea:RHEA-COMP:17339,
CC Rhea:RHEA-COMP:17340, ChEBI:CHEBI:33019, ChEBI:CHEBI:61560,
CC ChEBI:CHEBI:173112; EC=2.7.7.7;
CC Evidence={ECO:0000256|ARBA:ARBA00024632};
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR RefSeq; XP_007450569.1; XM_007450507.1.
DR STRING; 118797.A0A340WU27; -.
DR GeneID; 103071547; -.
DR KEGG; lve:103071547; -.
DR CTD; 10721; -.
DR InParanoid; A0A340WU27; -.
DR OrthoDB; 208079at2759; -.
DR Proteomes; UP000265300; Unplaced.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-KW.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR GO; GO:0003887; F:DNA-directed DNA polymerase activity; IEA:UniProtKB-EC.
DR GO; GO:0006281; P:DNA repair; IEA:UniProt.
DR GO; GO:0006261; P:DNA-templated DNA replication; IEA:InterPro.
DR CDD; cd18026; DEXHc_POLQ-like; 1.
DR CDD; cd08638; DNA_pol_A_theta; 1.
DR CDD; cd18795; SF2_C_Ski2; 1.
DR Gene3D; 1.10.3380.20; -; 1.
DR Gene3D; 3.30.70.370; -; 1.
DR Gene3D; 1.10.150.20; 5' to 3' exonuclease, C-terminal subdomain; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 2.
DR Gene3D; 3.30.420.10; Ribonuclease H-like superfamily/Ribonuclease H; 1.
DR InterPro; IPR011545; DEAD/DEAH_box_helicase_dom.
DR InterPro; IPR019760; DNA-dir_DNA_pol_A_CS.
DR InterPro; IPR001098; DNA-dir_DNA_pol_A_palm_dom.
DR InterPro; IPR043502; DNA/RNA_pol_sf.
DR InterPro; IPR002298; DNA_polymerase_A.
DR InterPro; IPR014001; Helicase_ATP-bd.
DR InterPro; IPR001650; Helicase_C.
DR InterPro; IPR046931; HTH_61.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR048960; POLQ-like_helical.
DR InterPro; IPR012337; RNaseH-like_sf.
DR InterPro; IPR036397; RNaseH_sf.
DR PANTHER; PTHR10133; DNA POLYMERASE I; 1.
DR PANTHER; PTHR10133:SF62; DNA POLYMERASE THETA; 1.
DR Pfam; PF00270; DEAD; 1.
DR Pfam; PF00476; DNA_pol_A; 2.
DR Pfam; PF00271; Helicase_C; 1.
DR Pfam; PF20470; HTH_61; 1.
DR Pfam; PF21099; POLQ_helical; 1.
DR SMART; SM00487; DEXDc; 1.
DR SMART; SM00490; HELICc; 1.
DR SMART; SM00482; POLAc; 1.
DR SUPFAM; SSF56672; DNA/RNA polymerases; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR SUPFAM; SSF53098; Ribonuclease H-like; 1.
DR SUPFAM; SSF158702; Sec63 N-terminal domain-like; 1.
DR PROSITE; PS00447; DNA_POLYMERASE_A; 1.
DR PROSITE; PS51192; HELICASE_ATP_BIND_1; 1.
DR PROSITE; PS51194; HELICASE_CTER; 1.
PE 4: Predicted;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Reference proteome {ECO:0000313|Proteomes:UP000265300}.
FT DOMAIN 108..292
FT /note="Helicase ATP-binding"
FT /evidence="ECO:0000259|PROSITE:PS51192"
FT DOMAIN 332..560
FT /note="Helicase C-terminal"
FT /evidence="ECO:0000259|PROSITE:PS51194"
FT REGION 1..64
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1783..1811
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2153..2173
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 20..34
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 47..64
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 2603 AA; 290419 MW; 178CD024CB01067A CRC64;
MNLTRWSGKR RRSAPGSDFF SGSGGDSSDS PLLLSGPVLS PPPGLRRSLK DRGRPPARAA
GKCKQTFPDD KVDKLLLANW GLPTAVLEKY HSFGVKKMFE WQAECLLLGQ VLEGKNLVYS
APTSAGKTLV AELLILKRVL ETRKKALFIL PFVSVAKEKK YYFQSLFQEV GIKVDGYMGS
TSPTGHFSSL DIAVCTIERA NGLINRLIEE NKMDLLGMVV VDELHMLGDS PRGYLLELLL
TKISYITQKS ASCQAYLASP LSNAVQIVGM SATLPNLELV ASWLNAELYH TDFRPVPLLE
SVKIGNSIYD SSLKPVREFQ PMLQVKGDED HVVSLCYETI RDNHSVLLFC PSKKWCEKLA
DIIAYAFYTL HHQAEGLVRS SELPPVILEQ KGLLEVMDQL KRLPSGLDSV LQKTVPWGVA
FHHAGLTFEE RDIIEGAFRQ GQIRVLAATS TLSSGVNLPA RRVIIRTPIF SGRPLDILTY
KQMVGRAGRK GVDTVGESIL VCKNSEKSKG IALLQGSLKP VRSCLQRQEG EEVTSSMIRA
ILEIIVGGLA STSQDIQTYA SCTFLAASMK EGKQGIQKNK DSVQLGAIEA CVMWLLENEF
IQITEASDGT EGSVYHPTHL GSATLSSSLS PVDTLDIFAD LQRAMKGFVL ENDLHIVYLV
TPVFEDWTTI DWYRFFCLWE KLPASMKRVA ELVGVEEGFL ARCVKGKVVA RTEKQHRQMA
IHKRFFTSLV LLDLISEVPL KEINQKYGCS RGQIQSLQQS AAVYAGMITV FSNRLGWHNM
ELLLSQFQKR LTFGIQRELC DLVRVSLLNA QRARFLYASG FLTVADLARA DVAEVESVLK
NAVPFKSTRK AVDEEEEAVE ERRXXXRTIW VSGRKDLTER EAATLMVEEA RMILQQDLVE
MGVQWSPYSL LNSDTHSLTC SESEVKEHKF IPQTKSSYKR LTSKKKSNTI FNDSSVTHLP
NTVQDLDKSR EHTDSFYYKF QDGHQEHQVH SISRAKKRAS LSINKEKLGT SLNEGKASTT
KVVQTLSSEK TKKEALNFSS EEMSTTSQSW KHSKNLKRSR DSSPVKDTRM CRINLQEQTL
SNPIHYEESF TSDEKNMEFR SPEPVAKSIS FCAEGRYSKV SFPSQTEQSC SRNNKISNDI
LVEYFITGSQ NKNVTHQATS VVSENGRGLA VESEKTNEVL IQNDSKNQHV NVKHHDTHPI
NQCLEKQFDK QTNTYTKLKK PIARQMPYEK DSSYMNRDSN VVMKCESTKF NAEENKSSNL
QVSGDNISST EISSGVHVLS GAFGKSGGQH ENILNTLRVQ VKTDAYAADG TKNNHVSDLG
LDLCDFEDSF YLDTQSEKII QQISTENAKQ EGAKDTSLAT GMMQKSLDKQ SSVSSFQKEI
HFTFPGEQHS PGMTNHLKLK TIDAMKQSTD SHGVDNLTPE SPIFYSPILI GENDPCFKGN
ELSVTDSQLN SFLQGYQTQE AMKPVIPLVP KIRTRTDIEV ECLPVPETSL NLSGSLLFDS
FSEEYLVEEQ PPDVQAKERL PSEITSVHFA DSLCLQPEGP IKKSDVNENQ DNQQPLSCFS
DESTIFSEMD SAQMVEALDN VDIFPVQEKH NTAGSLRVLK LSDPVIVGKD YSQREVIGRD
KDKRSQKSKF TGTRQDNSFI WSGASFDFSP GLQRILDNVS SPLENEKLKL TITDLLSLKG
KNTEVNDKQE VISNLETNRV QGIPFSPNVV KGNIDALENN VIHGETSLLP CKENCIVDDN
GLIPPIPSAS KLSFPGFLGT SSVKLKKISG GLQLGESYSF GSPSDNKNCD LNPESRNGFK
DDSPIRDTSF SPQLSQDGLQ LTLASCSSES LAIIDVASDQ TLFQTFMKEW QNKTRFSISL
ACEKISNLTS SKSATIGGRF KQVSSSQESH IGDDGIPVKG CDGILVVGLA VCWGGRDAYY
FSLQKEQKHS EISASLAPPS LDPSLTVKDR MRHLQSCFQK DSDKEHSVII YDFIQSYKIL
LLSCGISLEQ SYEDPKVACW LLDPDSKEPT LHGIVSRFLP HELPLLEEIE TGQGTHSLGL
HVTTEHSGRY RASVESILIF SSMNQLNSLL KKENLQDVFC KVEMPSQYCL ALLELNGIGF
STAECESQKH IMQAKLDAIE TQAYQLAGHS FSFTSSDDIA EVLFLELKLP PNGERKHQGS
KKTLGSTRRG NDDGWKLRLG KQFSTSKDVL NKLRALHPLP GLILEWRRIT NAITKVVFPL
QREKRLNRFL GMERIYPVSQ SHTATGRITF IEPNIQNVPR DFEIKMPTLV EESPPSQALG
KGLLPMGRGG KKKGCGLNPR QQAKMEERAS DRGMPXXXXX MPFSVSMRHA FVPFPGGLIL
AADYSQLELR ILAHLSHDHR LIQVLNTGAD VFRSIAAEWK MIEPESVGDD LRQQAKQICY
GIIYGMGAKS LGEQMGIKEN DAAFYIDSFK SRYTGINHFM RETVKNCKRD GFVQTILGRH
RYLPGIKDNN PYHKAHAERQ AINTRVQGSA ADIVKIATVN IQKQLETFHS TFKSHGHRES
MLQNDRTGLL PKRKLQGMFC PIRGGFFILQ LHDELLYEVA EEDVVQVAQI VKNEMESAIK
LSVKLKVKVK IGASWGELKD FDV
//
