ID   A0A340WUI6_LIPVE        Unreviewed;      1259 AA.
AC   A0A340WUI6;
DT   10-OCT-2018, integrated into UniProtKB/TrEMBL.
DT   10-OCT-2018, sequence version 1.
DT   27-MAR-2024, entry version 24.
DE   SubName: Full=Regulator of nonsense transcripts 2 {ECO:0000313|RefSeq:XP_007452651.1};
GN   Name=UPF2 {ECO:0000313|RefSeq:XP_007452651.1};
OS   Lipotes vexillifer (Yangtze river dolphin).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Whippomorpha; Cetacea; Odontoceti;
OC   Lipotidae; Lipotes.
OX   NCBI_TaxID=118797 {ECO:0000313|Proteomes:UP000265300, ECO:0000313|RefSeq:XP_007452651.1};
RN   [1] {ECO:0000313|RefSeq:XP_007452651.1}
RP   IDENTIFICATION.
RG   RefSeq;
RL   Submitted (NOV-2023) to UniProtKB.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
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DR   RefSeq; XP_007452651.1; XM_007452589.1.
DR   AlphaFoldDB; A0A340WUI6; -.
DR   STRING; 118797.A0A340WUI6; -.
DR   GeneID; 103069173; -.
DR   KEGG; lve:103069173; -.
DR   CTD; 26019; -.
DR   InParanoid; A0A340WUI6; -.
DR   OrthoDB; 276824at2759; -.
DR   Proteomes; UP000265300; Unplaced.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0003723; F:RNA binding; IEA:InterPro.
DR   GO; GO:0000184; P:nuclear-transcribed mRNA catabolic process, nonsense-mediated decay; IEA:InterPro.
DR   Gene3D; 1.25.40.180; -; 3.
DR   Gene3D; 4.10.80.160; -; 1.
DR   Gene3D; 6.10.250.770; -; 1.
DR   InterPro; IPR016024; ARM-type_fold.
DR   InterPro; IPR003890; MIF4G-like_typ-3.
DR   InterPro; IPR039762; Nmd2/UPF2.
DR   InterPro; IPR007193; Upf2/Nmd2_C.
DR   PANTHER; PTHR12839; NONSENSE-MEDIATED MRNA DECAY PROTEIN 2 UP-FRAMESHIFT SUPPRESSOR 2; 1.
DR   PANTHER; PTHR12839:SF7; REGULATOR OF NONSENSE TRANSCRIPTS 2; 1.
DR   Pfam; PF02854; MIF4G; 3.
DR   Pfam; PF04050; Upf2; 1.
DR   SMART; SM00543; MIF4G; 3.
DR   SUPFAM; SSF48371; ARM repeat; 3.
PE   4: Predicted;
KW   Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW   Reference proteome {ECO:0000313|Proteomes:UP000265300}.
FT   DOMAIN          157..353
FT                   /note="MIF4G"
FT                   /evidence="ECO:0000259|SMART:SM00543"
FT   DOMAIN          558..747
FT                   /note="MIF4G"
FT                   /evidence="ECO:0000259|SMART:SM00543"
FT   DOMAIN          762..975
FT                   /note="MIF4G"
FT                   /evidence="ECO:0000259|SMART:SM00543"
FT   REGION          1..117
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          413..436
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          480..506
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          1007..1087
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          1210..1259
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1014..1067
FT                   /note="Acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1068..1086
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   1259 AA;  146518 MW;  1141671B6B153D3F CRC64;
     MPAERKKPAS MEEKESLLNS KEKDCSERRP VSSREKPKEE IKLTAKKEVI KIPEDKKKKL
     EEDKRKKEDK ERKKKEEEKV KAEEELKKKE EEEKKKHEEE RKKQEEQAKR QEKEESLQLH
     QEAWERHQLR KELRSRNQNA PDNRPEENFF SRLDSSLKKN TAFVKKLKTI TEQQRDSLSH
     DFNGLNLSKY IAEAVASIVE AKLKISDVNC AVHLCSLFHQ RYADFAPSLL QVWKKHFEAR
     REEKTPNITK LRTDLRFIAE LTIVGIFTDK EGLSVIYEQL KNIINADRES HTHVSVVISF
     CRHCGDDIAG LVPRKVKSAA EKFNLSFPPS EIISPEKQQP FQNLLKEYFT SLTKHLKRDH
     RELQNTERQN RRILHSKGEL SEDRHKQYEE FAMSYQKLLA NSQSLADLLD ENMPDLPQDK
     PTPEEHGPGI DIFTPGKPGD YDLEGGIWED EDARNFYENL IDLKAFVPAI LFKDNEKSCQ
     NKESNKDDYK EAKEPKDNKE VSSPDDLELE LENLEINDDT LELEGGDEAE DLTKKLLDEQ
     EQEDEEASTG SHLKLIVDAF LQQLPNCVNR DLIDKAAMDF CMNMNTKANR KKLVRALFIV
     PRQRLDLLPF YARLVATLHP CMSDVAEDLC SMLRGDFRFH VRKKDQINIE TKNKTVRFIG
     ELTKFKMFTK NDTLHCLKML LSDFSHHHIE MACTLLETCG RFLFRSPESH LRTSVLLEQM
     MRKKQAMHLD ARYVTMVENA YYYCNPPPAE KTVKKKRPPL QEYVRKLLYK DLSKVTTEKV
     LRQMRKLPWQ DQEVKDYVIC CMINIWNVKY NSIHCVANLL AGLVLYQEDV GIHVVDGVLE
     DIRLGMEVNQ PKFNQRRISS AKFLGELYNY RMVESAVIFR TLYSFTSFGV NPDGSPSSLD
     PPEHLFRIRL VCTILDTCGQ YFDRGSSKRK LDCFLVYFQR YVWWKKSLEV WTKDHPFPID
     IDYMISDTLE LLRPKIKLCN SLEESIRQVH DLEREFLIKL GLVNDKDSKD SMTEGENLEE
     DEEEEEGGAE TEEQSGNESE VNEPEEEEGS DNDDDEGEEE EEENTDYLTD SNKENETDEE
     NTEVMIKGGG LKHVPCVEDE DFIQALDKMM LENLQQRSGE SVKVHQLDVA IPLHLKSQLR
     KGPPLGGGEG ETESADTMPF VMLTRKGNKQ QFKILNVPMS SQLAANHWNQ QQAEQEERMR
     MKKLTLDINE RQEQEDYQEM LQSLAQRPAP ANTNRERRPR YQHPKGAPNA DLIFKTGGR
//