ID A0A340WZS5_LIPVE Unreviewed; 507 AA.
AC A0A340WZS5;
DT 10-OCT-2018, integrated into UniProtKB/TrEMBL.
DT 10-OCT-2018, sequence version 1.
DT 27-MAR-2024, entry version 27.
DE SubName: Full=Solute carrier family 2, facilitated glucose transporter member 6 {ECO:0000313|RefSeq:XP_007453137.1};
GN Name=SLC2A6 {ECO:0000313|RefSeq:XP_007453137.1};
OS Lipotes vexillifer (Yangtze river dolphin).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Whippomorpha; Cetacea; Odontoceti;
OC Lipotidae; Lipotes.
OX NCBI_TaxID=118797 {ECO:0000313|Proteomes:UP000265300, ECO:0000313|RefSeq:XP_007453137.1};
RN [1] {ECO:0000313|RefSeq:XP_007453137.1}
RP IDENTIFICATION.
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004651};
CC Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004651}. Membrane
CC {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the major facilitator superfamily. Sugar
CC transporter (TC 2.A.1.1) family. Glucose transporter subfamily.
CC {ECO:0000256|ARBA:ARBA00007004}.
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DR RefSeq; XP_007453137.1; XM_007453075.1.
DR AlphaFoldDB; A0A340WZS5; -.
DR STRING; 118797.A0A340WZS5; -.
DR GeneID; 103081218; -.
DR KEGG; lve:103081218; -.
DR CTD; 11182; -.
DR InParanoid; A0A340WZS5; -.
DR OrthoDB; 2469693at2759; -.
DR Proteomes; UP000265300; Unplaced.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0022857; F:transmembrane transporter activity; IEA:InterPro.
DR GO; GO:0008643; P:carbohydrate transport; IEA:UniProtKB-KW.
DR Gene3D; 1.20.1250.20; MFS general substrate transporter like domains; 1.
DR InterPro; IPR020846; MFS_dom.
DR InterPro; IPR005828; MFS_sugar_transport-like.
DR InterPro; IPR036259; MFS_trans_sf.
DR InterPro; IPR003663; Sugar/inositol_transpt.
DR InterPro; IPR005829; Sugar_transporter_CS.
DR NCBIfam; TIGR00879; SP; 1.
DR PANTHER; PTHR48021; -; 1.
DR PANTHER; PTHR48021:SF59; SOLUTE CARRIER FAMILY 2, FACILITATED GLUCOSE TRANSPORTER MEMBER 6; 1.
DR Pfam; PF00083; Sugar_tr; 1.
DR PRINTS; PR00171; SUGRTRNSPORT.
DR SUPFAM; SSF103473; MFS general substrate transporter; 1.
DR PROSITE; PS50850; MFS; 1.
DR PROSITE; PS00216; SUGAR_TRANSPORT_1; 1.
DR PROSITE; PS00217; SUGAR_TRANSPORT_2; 1.
PE 3: Inferred from homology;
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000265300};
KW Sugar transport {ECO:0000313|RefSeq:XP_007453137.1};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|RuleBase:RU003346}.
FT TRANSMEM 38..63
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 83..103
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 110..130
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 136..157
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 169..187
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 193..214
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 340..362
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 396..420
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 432..453
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 465..483
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 41..487
FT /note="Major facilitator superfamily (MFS) profile"
FT /evidence="ECO:0000259|PROSITE:PS50850"
FT REGION 1..28
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 507 AA; 54165 MW; B23AE5B3CAD43CF2 CRC64;
MQEPLLGAEG PDYDTFPEKP APSPGETTRV GALQNKRVFL ATFAAVLGNF SFGYALVYTS
PVIPALEHTL DPNLSLTKTQ ASWFGSVFTL GAAAGGLSAM VLNDLLGRKL SIMFSAVPSA
AGYALMAGAH GLWMLLLGRT LTGFAGGLTA ACIPVYVSEI APAGVRGALG ATPQLMAVFG
SLSLYALGLL LPWRWLAVAG EGPVLVMILL LCFMPNSPRF LLSRGRDSEA LQALAWLRGA
DTDIRREFEQ IQDNVRRQSS HLSWAEARDP HIYRPIVIAL LMRFLQQLTG ITPILVYLQS
IFDSTAVLLP PEDDAAIVGA VRLLSVLIAA LTMDLAGRKA LLFVSAASMF AANLTLGLYV
HFGPKPLTPN GTMGLESVPL GGTEQPLATP TSYLSLVPLL ATMLFIMGYA MGWGPITWLL
MSEILPLRAR GVASGLCVLV SWLTAFALTK SFLLVVDALG LQAPFFFFAA VCSVSLAFTG
CCVPETKGRS LEQIESSFRS GRRSFLC
//
