ID A0A340X0I7_LIPVE Unreviewed; 747 AA.
AC A0A340X0I7;
DT 10-OCT-2018, integrated into UniProtKB/TrEMBL.
DT 10-OCT-2018, sequence version 1.
DT 27-MAR-2024, entry version 23.
DE RecName: Full=Myotubularin-related protein 12 {ECO:0000256|ARBA:ARBA00018495};
DE AltName: Full=Inactive phosphatidylinositol 3-phosphatase 12 {ECO:0000256|ARBA:ARBA00033343};
GN Name=MTMR12 {ECO:0000313|RefSeq:XP_007453422.1};
OS Lipotes vexillifer (Yangtze river dolphin).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Whippomorpha; Cetacea; Odontoceti;
OC Lipotidae; Lipotes.
OX NCBI_TaxID=118797 {ECO:0000313|Proteomes:UP000265300, ECO:0000313|RefSeq:XP_007453422.1};
RN [1] {ECO:0000313|RefSeq:XP_007453422.1}
RP IDENTIFICATION.
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cytoplasm, myofibril, sarcomere
CC {ECO:0000256|ARBA:ARBA00004204}. Sarcoplasmic reticulum
CC {ECO:0000256|ARBA:ARBA00004369}.
CC -!- SIMILARITY: Belongs to the protein-tyrosine phosphatase family. Non-
CC receptor class myotubularin subfamily. {ECO:0000256|ARBA:ARBA00007471}.
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DR RefSeq; XP_007453422.1; XM_007453360.1.
DR AlphaFoldDB; A0A340X0I7; -.
DR STRING; 118797.A0A340X0I7; -.
DR GeneID; 103078267; -.
DR CTD; 54545; -.
DR InParanoid; A0A340X0I7; -.
DR OrthoDB; 5474662at2759; -.
DR Proteomes; UP000265300; Unplaced.
DR GO; GO:0030017; C:sarcomere; IEA:UniProtKB-SubCell.
DR GO; GO:0016529; C:sarcoplasmic reticulum; IEA:UniProtKB-SubCell.
DR CDD; cd14594; PTP-MTMR12; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR InterPro; IPR022587; MTMR12-like_C.
DR InterPro; IPR030576; MTMR12_PTP.
DR InterPro; IPR010569; Myotubularin-like_Pase_dom.
DR InterPro; IPR030564; Myotubularin_fam.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR029021; Prot-tyrosine_phosphatase-like.
DR PANTHER; PTHR10807; MYOTUBULARIN-RELATED; 1.
DR PANTHER; PTHR10807:SF37; MYOTUBULARIN-RELATED PROTEIN 12; 1.
DR Pfam; PF12578; 3-PAP; 1.
DR Pfam; PF06602; Myotub-related; 1.
DR SUPFAM; SSF52799; (Phosphotyrosine protein) phosphatases II; 1.
DR SUPFAM; SSF50729; PH domain-like; 1.
DR PROSITE; PS51339; PPASE_MYOTUBULARIN; 1.
PE 3: Inferred from homology;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Reference proteome {ECO:0000313|Proteomes:UP000265300};
KW Sarcoplasmic reticulum {ECO:0000256|ARBA:ARBA00022951}.
FT DOMAIN 205..643
FT /note="Myotubularin phosphatase"
FT /evidence="ECO:0000259|PROSITE:PS51339"
FT COILED 661..691
FT /evidence="ECO:0000256|SAM:Coils"
SQ SEQUENCE 747 AA; 85995 MW; 43E27F03BD370435 CRC64;
MLGKGVVGGG GGTKAPKPSF VSYVRPEEIH ANEKEVTEKE VTLHLLPGEQ LLCEASTVLK
CVQEDSCQRG IYGRLVCTDF KIAFLGDDES ALDNDETQFK NKVIGENDIT LHCVDQIYGV
FDEKKKTLFG QLKKYPEKLI IHCKDLRVFH FCLRYTKEEE VKRIVSGIIH HTQAPKLLKR
LFLFSYATAA QNHTATDPKS HAVMFDTLQD WCWELERTKG NRKYKAVSVN EGYRVCERLP
AYFVVPTPLP EEDVPRFHGH GIPIWCWSCH SGCALLKMSA LPKEQDDGIL QIQKNFLDGI
YKTIHRPPYE IVKTEDLSSN FLSLQEIQTA YSKFKQLFLI DNSTEFWDTD IKWFSLLESS
SWLDIIRRCL KKAIEIIECL EAQNMNVLLL EENASDLCCL VSSLVQVMMD PHCRTRFGFQ
SLVQKEWIVG GHCFLDRCNH LRQSDKEEVP VFLLFLDCVW QLVHQHPPAF EFTETYLTVL
SDSLYIPIFS TFFLNSPHQK DTNMGRESQG AQSKPLKLLT VWDWSVQFEP KAQTLLKNPL
YVEKPKLDKG QRKGTHFKHQ RQLSLPLTQS KSSPKRGFFR EETDHLIKNL LGKRISKLIN
SSEELQDNFR EFYDSWRSKP PNYHGLLLPH IEGPEIKVWA QRYLRWIPEA QILGGGRVAT
LSKLLETMEE VQRLQEKIEE RHHSQEALQA EAASLLRTSA RLSSLFPFAL LQRHSSKPVL
PTSGWKALGD EEDLAKREDE FVDLGDV
//
