ID A0A340X0K6_LIPVE Unreviewed; 2119 AA.
AC A0A340X0K6;
DT 10-OCT-2018, integrated into UniProtKB/TrEMBL.
DT 10-OCT-2018, sequence version 1.
DT 27-MAR-2024, entry version 23.
DE SubName: Full=Dysferlin isoform X2 {ECO:0000313|RefSeq:XP_007453442.1};
GN Name=DYSF {ECO:0000313|RefSeq:XP_007453442.1};
OS Lipotes vexillifer (Yangtze river dolphin).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Whippomorpha; Cetacea; Odontoceti;
OC Lipotidae; Lipotes.
OX NCBI_TaxID=118797 {ECO:0000313|Proteomes:UP000265300, ECO:0000313|RefSeq:XP_007453442.1};
RN [1] {ECO:0000313|RefSeq:XP_007453442.1}
RP IDENTIFICATION.
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cytoplasmic vesicle membrane
CC {ECO:0000256|ARBA:ARBA00004483}; Single-pass type II membrane protein
CC {ECO:0000256|ARBA:ARBA00004483}. Membrane
CC {ECO:0000256|ARBA:ARBA00004606}; Single-pass type II membrane protein
CC {ECO:0000256|ARBA:ARBA00004606}.
CC -!- SIMILARITY: Belongs to the ferlin family.
CC {ECO:0000256|ARBA:ARBA00007561}.
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DR RefSeq; XP_007453442.1; XM_007453380.1.
DR GeneID; 103085415; -.
DR CTD; 8291; -.
DR OrthoDB; 991411at2759; -.
DR Proteomes; UP000265300; Unplaced.
DR GO; GO:0030659; C:cytoplasmic vesicle membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-KW.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR CDD; cd08373; C2A_Ferlin; 1.
DR CDD; cd04011; C2B_Ferlin; 1.
DR CDD; cd04018; C2C_Ferlin; 1.
DR CDD; cd04017; C2D_Ferlin; 1.
DR CDD; cd04037; C2E_Ferlin; 1.
DR CDD; cd08374; C2F_Ferlin; 1.
DR Gene3D; 2.60.40.150; C2 domain; 6.
DR InterPro; IPR000008; C2_dom.
DR InterPro; IPR035892; C2_domain_sf.
DR InterPro; IPR037726; C2A_Ferlin.
DR InterPro; IPR037720; C2B_Ferlin.
DR InterPro; IPR037722; C2C_Ferlin.
DR InterPro; IPR037723; C2D_Ferlin.
DR InterPro; IPR037724; C2E_Ferlin.
DR InterPro; IPR037725; C2F_Ferlin.
DR InterPro; IPR012968; FerIin_dom.
DR InterPro; IPR037721; Ferlin.
DR InterPro; IPR012560; Ferlin_A-domain.
DR InterPro; IPR012561; Ferlin_B-domain.
DR InterPro; IPR032362; Ferlin_C.
DR InterPro; IPR006614; Peroxin/Ferlin.
DR PANTHER; PTHR12546:SF44; DYSFERLIN; 1.
DR PANTHER; PTHR12546; FER-1-LIKE; 1.
DR Pfam; PF00168; C2; 7.
DR Pfam; PF08165; FerA; 1.
DR Pfam; PF08150; FerB; 1.
DR Pfam; PF08151; FerI; 1.
DR Pfam; PF16165; Ferlin_C; 1.
DR SMART; SM00239; C2; 7.
DR SMART; SM00694; DysFC; 2.
DR SMART; SM00693; DysFN; 2.
DR SMART; SM01200; FerA; 1.
DR SMART; SM01201; FerB; 1.
DR SMART; SM01202; FerI; 1.
DR SUPFAM; SSF49562; C2 domain (Calcium/lipid-binding domain, CaLB); 7.
DR PROSITE; PS50004; C2; 7.
PE 3: Inferred from homology;
KW Calcium {ECO:0000256|ARBA:ARBA00022837};
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Cytoplasmic vesicle {ECO:0000256|ARBA:ARBA00023329};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Reference proteome {ECO:0000313|Proteomes:UP000265300};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Signal-anchor {ECO:0000256|ARBA:ARBA00022968};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 2085..2106
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 1..101
FT /note="C2"
FT /evidence="ECO:0000259|PROSITE:PS50004"
FT DOMAIN 235..353
FT /note="C2"
FT /evidence="ECO:0000259|PROSITE:PS50004"
FT DOMAIN 392..528
FT /note="C2"
FT /evidence="ECO:0000259|PROSITE:PS50004"
FT DOMAIN 1154..1280
FT /note="C2"
FT /evidence="ECO:0000259|PROSITE:PS50004"
FT DOMAIN 1328..1456
FT /note="C2"
FT /evidence="ECO:0000259|PROSITE:PS50004"
FT DOMAIN 1600..1718
FT /note="C2"
FT /evidence="ECO:0000259|PROSITE:PS50004"
FT DOMAIN 1834..1982
FT /note="C2"
FT /evidence="ECO:0000259|PROSITE:PS50004"
FT REGION 177..252
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2034..2056
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 214..228
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 2119 AA; 240927 MW; D6ACD6A9A552498A CRC64;
MLRVFILYAE NVHTPDADIS DAYCSAVFAG VKKRTKVIKN NVNPVWNEGF EWDLKGVPLD
QGSELHVVVK DHETMGRNRF LGEANVPLRE VLATPSLSAS FNAPLLDTKK QPTGASLVLQ
VSYTPLPGTM PTFPPSMPLE PSPTLPDMDM VAGGGQSRAE TWSLLSDSTV DTRYSGKKWL
APTDTGDEDT EDQGLTGDEA EPLLDQSGAP GPGAPITPKK PPSHPPPYHP GGRRKRSTPA
PRKPLSDKSQ DFQIRVQVIE GRQLPGVNIK PVVKVTAAGQ TKRTRIHKGN SPRFNETLFF
NVFDSPAELF DEPIFITVVD SCSLRTDALI GEFRMDVGSI YREPRHAYLR KWLLLSDLDD
FSAGARGYLK VSLCVLGPGD EAPLERKDPS EDKEDIEGNL LRPTGVALRG AHFCLKVFRA
EDLPQMDDAV MDNVKQIFGF ESNKKNLVDP FVDVSFAGKM LCSKILEKTA NPQWNQSITV
PAMFPSMCEK MRIRVIDWDR LTHNDIVATT YLSMSKISAS GGEIEVDDHL GFLPTFGPCY
VNLYGSPREF TGFPDPYAEL NTGKGEGVAY RGRLLLSLET KLVEHSEQKV EDLPADDILR
VEKYLRRRKY SLFAAFYSAT MLQDVDDAVQ FEVSVGNYGN KFDTTCLPLA STTQYSRAVF
DGCHYYYLPW GNVKPVVVLS SYWEDISHRV EAQNQLLRIA DQLEAGLEQV HLALKAQHSA
EDVDSLVAQL MDELIAGCSQ PLGNVQETPS ATHLDHYLYR LRTRHLSQIT EAAQALKLGH
SELPTALEQA EDWLLRLRAL ADEPQNSLPD IVIWMLQGDK RVAYQRVPAH EVLFSRRGTT
YCGKNCGKLQ TMFLKYPMEG VPGARMPAQI RVRLWFGLSV DEKEFNQFAE GKLSVFAETY
ENQTKLALVG NWGTTGLTYP KFSDVTGKIK LPKESFRPSA GWAWAGDWFV CPEKTLLHDT
DAGHLSFVEE VFENQTRLPG GQWIYMSDNY TDVNGEKVLP KDDIECPLGW KWEDEEWSTD
LNRAVDEQGW EYSITIPPDR KPRHWVPAEK MYYTHRRRRW VRLRRRDLSQ MEALKRHRQA
EAEGEGWEYA SLFGWKFHLE YRKTDAFRRR RWRRRMEPLE RTGPAAVFAL EGALGGVVDD
RSEDSKTVST LSFGVNRPTI SCIFDCGNRY HLRCYMYQAR DLPAMDKDSF SDPYAIVSFL
HQSQKTVVVK NTLNPTWDQT LIFYEIEIFG EPASAAEQPA SLVVELYDHD AYGADEFMGR
CICQPSLERM PRLAWFPLTR GNQPAGELLA SFELIQREKP AIHHIPGFEV QDTSGILEES
EDTDLPYPPP QREANIYMVP QNIKPVLQRT AIEILAWGLR NMKSYQLASV SSPSLVVECG
GQTVQSCVIK NLRKNPNFDI CTLFMEVMLP REELYCPPVV IKVIDNRQFG RRPVVGQCTI
RSLESFLCDP YSEESPSPQG GPDDVSLLSP GEDVLIDIDD KEPLIPIQLA DGLSGFAPTN
MASSPSSRHE EEFIDWWSKF FASIGEREKC GSYLEKDFDT LKVYDTPLEN VKDFEGLSDF
CNTFKLYRGK TQEEMEDPSV IGEFKGLFKI YPLPEDPAIP IPPRQFHQLA AQGPQECLVR
IYIIRAFGLQ PKDPNGKCDP YIRISIGKKS VSDQDSYIPC TLEPVFGKMF ELTCTLPLEK
DLKVTLYDYD LLSKDEKIGE TVIDLENRLL SKFGARCGLP QTYCISGPNQ WRDQLHPSQL
LHLFCQQRRV KAPVYRTDRV VFQDKEYTIE EIEAGRVPNP HLGPVEERLA LHVLRQQGLV
PEHVESRPLY SPLQPDIEQG KLQMWIDLFP KALGRPGPPF NITPRRARRF FLRCIIWNTK
DVILDDLSIT GEKMSDIYVK GWMVGFEEHK QKTDVHYRSL GGEGNFNWRF IFPFDYLPAE
QVCTVSKKDA FWRLDKTESK IPARAVFQIW DNDKFSFDDF LGSLQLDLNR LPKPAKTAEK
CSLDQLDDTF HPEWFVSLFE QKTVKGWWPC VADEGEKKIL AGKLEMTLEI VAESEHEERP
AGQGRDEPNM NPKLEDPRRP DTSFLWFTSP YKTMKFILWR RFRCAIILLI LLFILLLFLG
IFVYSFPNYT AMKLVKPFS
//
