ID A0A340X1H0_LIPVE Unreviewed; 780 AA.
AC A0A340X1H0;
DT 10-OCT-2018, integrated into UniProtKB/TrEMBL.
DT 10-OCT-2018, sequence version 1.
DT 24-JAN-2024, entry version 25.
DE RecName: Full=Pendrin {ECO:0000256|RuleBase:RU362052};
DE AltName: Full=Sodium-independent chloride/iodide transporter {ECO:0000256|RuleBase:RU362052};
DE AltName: Full=Solute carrier family 26 member 4 {ECO:0000256|RuleBase:RU362052};
GN Name=SLC26A4 {ECO:0000313|RefSeq:XP_007455438.1};
OS Lipotes vexillifer (Yangtze river dolphin).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Whippomorpha; Cetacea; Odontoceti;
OC Lipotidae; Lipotes.
OX NCBI_TaxID=118797 {ECO:0000313|Proteomes:UP000265300, ECO:0000313|RefSeq:XP_007455438.1};
RN [1] {ECO:0000313|RefSeq:XP_007455438.1}
RP IDENTIFICATION.
RG RefSeq;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- FUNCTION: Sodium-independent transporter of chloride and iodide.
CC {ECO:0000256|RuleBase:RU362052}.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141,
CC ECO:0000256|RuleBase:RU362052}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004141, ECO:0000256|RuleBase:RU362052}.
CC -!- SIMILARITY: Belongs to the SLC26A/SulP transporter (TC 2.A.53) family.
CC {ECO:0000256|RuleBase:RU362052}.
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DR RefSeq; XP_007455438.1; XM_007455376.1.
DR STRING; 118797.A0A340X1H0; -.
DR GeneID; 103083039; -.
DR KEGG; lve:103083039; -.
DR CTD; 5172; -.
DR InParanoid; A0A340X1H0; -.
DR OrthoDB; 1067648at2759; -.
DR Proteomes; UP000265300; Unplaced.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0008509; F:monoatomic anion transmembrane transporter activity; IEA:UniProtKB-UniRule.
DR GO; GO:0008271; F:secondary active sulfate transmembrane transporter activity; IEA:InterPro.
DR Gene3D; 3.30.750.24; STAS domain; 1.
DR InterPro; IPR018045; S04_transporter_CS.
DR InterPro; IPR011547; SLC26A/SulP_dom.
DR InterPro; IPR001902; SLC26A/SulP_fam.
DR InterPro; IPR002645; STAS_dom.
DR InterPro; IPR036513; STAS_dom_sf.
DR NCBIfam; TIGR00815; sulP; 1.
DR PANTHER; PTHR11814:SF33; PENDRIN; 1.
DR PANTHER; PTHR11814; SULFATE TRANSPORTER; 1.
DR Pfam; PF01740; STAS; 1.
DR Pfam; PF00916; Sulfate_transp; 1.
DR SUPFAM; SSF52091; SpoIIaa-like; 1.
DR PROSITE; PS01130; SLC26A; 1.
DR PROSITE; PS50801; STAS; 1.
PE 3: Inferred from homology;
KW Chloride {ECO:0000256|RuleBase:RU362052};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|RuleBase:RU362052};
KW Reference proteome {ECO:0000313|Proteomes:UP000265300};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW ECO:0000256|RuleBase:RU362052};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|RuleBase:RU362052}; Transport {ECO:0000256|RuleBase:RU362052}.
FT TRANSMEM 105..130
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362052"
FT TRANSMEM 186..212
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362052"
FT TRANSMEM 218..240
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362052"
FT TRANSMEM 247..264
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362052"
FT TRANSMEM 270..288
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362052"
FT TRANSMEM 300..317
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362052"
FT TRANSMEM 352..373
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362052"
FT TRANSMEM 385..407
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362052"
FT TRANSMEM 422..442
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362052"
FT TRANSMEM 479..507
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362052"
FT DOMAIN 535..729
FT /note="STAS"
FT /evidence="ECO:0000259|PROSITE:PS50801"
SQ SEQUENCE 780 AA; 85537 MW; 52A262B8CA77E3B5 CRC64;
MAAPGGRLEP PPLPEYSCSY VVSRPVYSEL AFQQQYERRL QERKTLRESL AKGCSCSRKR
TLGVLKTLLP ILDWLPKYRI KEWLLSDTIS GFSTGLVGTL QGMAYALLAA VPVGYGLYSA
FFPILTYFIF GTSRHISVGP FPVVSLMVGS VVLSMAPDEH FLVSSSNGTT LNTTMIDSAA
RDAARVLIAS TLTLLVGIIQ LIFGGLQIGF IVRYLADPLV GGFTTAAAFQ VLVSQLKIVL
NVSTKNYNGI LSIIYTLIEI FQNIGNTNLA DFIAGLLTII ICMAVKELND RFKHKIPVPI
PIEVIVTIIA TAISYGVDLE KNYNAGIVKS IPSGFLPPAI PSVSLFSEML TASFSIAVVA
YAIAVSVGKV YAIKYDYTID GNQEFIAFGI SNIFSGFFSC FVATTALSRT AVQESTGGKT
QVAGMISAGI VMIAIVALGK LLEPLQKSVL AAVVIANLKG MFMQVCDIPR LWRQNKTDAV
IWVFTCVASI ILGLDLGLLA GLIFGFLTVV LRVQFPSWNS LGSIPSTDIY KSTKNYKNIE
EPEGVKILRF SSPIFYGNVD GLKKCIKSTV GFDAIRVYNK RLKALRKIQK LIKKGQLRAT
KDGIISDAGS SNNAFEPDED IENPEEFDIP TKEIEIQVDW NAELPVKVNV PKVPIHSLVL
DCGAVSFLDV VGVRSLRVVR NFQGMKTNXT LSLSFEDHVI EKLEKCGFFN DNIRKDIFFL
TVHDAVLHLQ NQVKSQEVQD SILETITLIQ DCKDPLELME AELIEEGLDV QDEAMRRLAS
//