ID A0A340X1K3_LIPVE Unreviewed; 1094 AA.
AC A0A340X1K3;
DT 10-OCT-2018, integrated into UniProtKB/TrEMBL.
DT 10-OCT-2018, sequence version 1.
DT 27-MAR-2024, entry version 21.
DE SubName: Full=Rap guanine nucleotide exchange factor 1 isoform X2 {ECO:0000313|RefSeq:XP_007453179.1};
GN Name=RAPGEF1 {ECO:0000313|RefSeq:XP_007453179.1};
OS Lipotes vexillifer (Yangtze river dolphin).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Whippomorpha; Cetacea; Odontoceti;
OC Lipotidae; Lipotes.
OX NCBI_TaxID=118797 {ECO:0000313|Proteomes:UP000265300, ECO:0000313|RefSeq:XP_007453179.1};
RN [1] {ECO:0000313|RefSeq:XP_007453179.1}
RP IDENTIFICATION.
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
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DR RefSeq; XP_007453179.1; XM_007453117.1.
DR AlphaFoldDB; A0A340X1K3; -.
DR GeneID; 103068519; -.
DR CTD; 2889; -.
DR OrthoDB; 68574at2759; -.
DR Proteomes; UP000265300; Unplaced.
DR GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:UniProtKB-KW.
DR GO; GO:0007264; P:small GTPase mediated signal transduction; IEA:InterPro.
DR CDD; cd00155; RasGEF; 1.
DR CDD; cd06224; REM; 1.
DR Gene3D; 1.10.840.10; Ras guanine-nucleotide exchange factors catalytic domain; 1.
DR Gene3D; 1.20.870.10; Son of sevenless (SoS) protein Chain: S domain 1; 1.
DR InterPro; IPR008937; Ras-like_GEF.
DR InterPro; IPR000651; Ras-like_Gua-exchang_fac_N.
DR InterPro; IPR019804; Ras_G-nucl-exch_fac_CS.
DR InterPro; IPR023578; Ras_GEF_dom_sf.
DR InterPro; IPR001895; RASGEF_cat_dom.
DR InterPro; IPR036964; RASGEF_cat_dom_sf.
DR PANTHER; PTHR23113; GUANINE NUCLEOTIDE EXCHANGE FACTOR; 1.
DR PANTHER; PTHR23113:SF99; RAP GUANINE NUCLEOTIDE EXCHANGE FACTOR 1; 1.
DR Pfam; PF00617; RasGEF; 1.
DR Pfam; PF00618; RasGEF_N; 1.
DR SMART; SM00147; RasGEF; 1.
DR SMART; SM00229; RasGEFN; 1.
DR SUPFAM; SSF48366; Ras GEF; 1.
DR PROSITE; PS00720; RASGEF; 1.
DR PROSITE; PS50009; RASGEF_CAT; 1.
DR PROSITE; PS50212; RASGEF_NTER; 1.
PE 4: Predicted;
KW Guanine-nucleotide releasing factor {ECO:0000256|ARBA:ARBA00022658,
KW ECO:0000256|PROSITE-ProRule:PRU00168};
KW Reference proteome {ECO:0000313|Proteomes:UP000265300}.
FT DOMAIN 705..827
FT /note="N-terminal Ras-GEF"
FT /evidence="ECO:0000259|PROSITE:PS50212"
FT DOMAIN 857..1081
FT /note="Ras-GEF"
FT /evidence="ECO:0000259|PROSITE:PS50009"
FT REGION 1..23
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 225..251
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 267..318
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 353..398
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 430..507
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 616..687
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 282..309
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 363..398
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 659..676
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1094 AA; 122555 MW; 70C6AE78F09DC853 CRC64;
MGNAIEKQKP LKRSHLCPWK QDSQRSHLSS FTMKLMDKFH SPKIKRTPSK KGKPAEVSVK
IPEKPVNKEA TDRFLPEGYP IPLDLEQQAV EFMSTSAVAS RSQRQKNLSW LEEKEKEVVS
ALRYFKTIVD KMAIDKKVLE MLPGSASKVL EAILPLVQSD PRIQHSSALS SCYSRVYQSL
ANLIRWSDQV MLEGVNSEDK EMVTTVKGVI KAVLDGVKEL VRLTIEKQGH PSPTSPVKPS
SPACKPDGQS ELPLTDREME ILNKTTGLSQ SAEGLPDSTD EEVAPPKPPL PGIRVVDNSP
PPALPPKKRQ SAPSPTRVAV VAPMSRATSG SSLPVGINRQ DFDVDCYAQR RLSGGSHSYG
GESPRLSPCS SIGKLSKSDE QLSSLDRDSG QCSRNTSCET LDHYDPDYEF LQQDLSNADQ
IPQQVACNLS PLPESLGESG SPFLGHPFQL PLGSCPQPEG PSAPGQQMDV PPALPEKKRR
SAASQTADSS GCRASYERHP SQYDNISEED LQNPASVQSV PFTPFAAILP FQQGGSSASV
EFVGDFTVPE STGDPEKPPP LPEKKNKHML AYMQLLEDYS EPQPSVFYRT PQKEHVYQQK
NKLLMEVYGF SDPFSAGDAP QELAPPPALP PKQRQLESPA SKDGHPRDAS SAGSAPGKES
RDGGDRAPKS PDAPEAQSEE EVDELSLIDH NEIMARLTLK QEGDDGPDVR GGSGDILLVH
ATETDRKDLV LYCEAFLTTY RTFISPEELI KKLQYRYEKF SPFADTFKKR VSKNTFFVLV
RVVDELCLVE LTEEILKLLM ELVFRLVCNG ELSLARVLRK NILDKVDQKK LLRCANSDQP
LAARGVAARP GTLHDFHSHE IAEQLTLLDA ELFYKIEIPE VLLWAKEQNE EKSPNLTQFT
EHFNNMSYWV RSIIMLQEKA QDRERLLLKF IKIMKHLRKL NNFNSYLAIL SALDSAPIRR
LEWQKQTSEG LAEYCTLIDS SSSFRAYRAA LSEVEPPCIP YLGLILQDLT FVHLGNPDYI
DGKVNFSKRW QQFNILDSMR CFQQAHYDIR RHDDVINFFN DFSDHLAEEA LWELSLKIKP
RNITRRRTDR EEKT
//
