ID A0A340X1K7_LIPVE Unreviewed; 503 AA.
AC A0A340X1K7;
DT 10-OCT-2018, integrated into UniProtKB/TrEMBL.
DT 10-OCT-2018, sequence version 1.
DT 27-MAR-2024, entry version 24.
DE SubName: Full=Potassium voltage-gated channel subfamily KQT member 4 isoform X2 {ECO:0000313|RefSeq:XP_007453802.1};
GN Name=KCNQ4 {ECO:0000313|RefSeq:XP_007453802.1};
OS Lipotes vexillifer (Yangtze river dolphin).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Whippomorpha; Cetacea; Odontoceti;
OC Lipotidae; Lipotes.
OX NCBI_TaxID=118797 {ECO:0000313|Proteomes:UP000265300, ECO:0000313|RefSeq:XP_007453802.1};
RN [1] {ECO:0000313|RefSeq:XP_007453802.1}
RP IDENTIFICATION.
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004651};
CC Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004651}. Membrane
CC {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004141}.
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DR RefSeq; XP_007453802.1; XM_007453740.1.
DR AlphaFoldDB; A0A340X1K7; -.
DR GeneID; 103080117; -.
DR CTD; 9132; -.
DR OrthoDB; 2911641at2759; -.
DR Proteomes; UP000265300; Unplaced.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005249; F:voltage-gated potassium channel activity; IEA:InterPro.
DR Gene3D; 1.10.287.70; -; 1.
DR Gene3D; 6.10.140.1910; -; 2.
DR InterPro; IPR005821; Ion_trans_dom.
DR InterPro; IPR003937; K_chnl_volt-dep_KCNQ.
DR InterPro; IPR013821; K_chnl_volt-dep_KCNQ_C.
DR PANTHER; PTHR47735; POTASSIUM VOLTAGE-GATED CHANNEL SUBFAMILY KQT MEMBER 4; 1.
DR PANTHER; PTHR47735:SF7; POTASSIUM VOLTAGE-GATED CHANNEL SUBFAMILY KQT MEMBER 4; 1.
DR Pfam; PF00520; Ion_trans; 1.
DR Pfam; PF03520; KCNQ_channel; 1.
DR PRINTS; PR00169; KCHANNEL.
DR PRINTS; PR01459; KCNQCHANNEL.
DR SUPFAM; SSF81324; Voltage-gated potassium channels; 1.
PE 4: Predicted;
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000265300};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 36..61
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 101..120
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 132..149
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 161..186
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 2..190
FT /note="Ion transport"
FT /evidence="ECO:0000259|Pfam:PF00520"
FT DOMAIN 272..454
FT /note="Potassium channel voltage dependent KCNQ C-terminal"
FT /evidence="ECO:0000259|Pfam:PF03520"
FT REGION 250..289
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 304..324
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 396..416
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 274..289
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 503 AA; 56540 MW; 1B402252301F6AC3 CRC64;
MIVVFGLEYI IRIWSAGCCC RYRGWQGRFR FARKPFCVID FIVFVASVAV IAAGTQGNIF
ATSALRSMRF LQILRMVRMD RRGGTWKLLG SVVYAHSKEL ITAWYIGFLV LIFASFLVYL
AEKDANSDFS SYADSLWWGT ITLTTIGYGD KTPHTWLGRV LAAGFALLGV SFFALPAGIL
GSGFALKVQE QHRQKHFEKR RMPAANLIQA AWRLYSTDTS RAYLTATWYY YDSILPSFNR
RMGIKDRIRM GSSQRRTGPS KQHLAPPPMP TSPSSEQVGE ASSPTKVQKS WSFNDRTRFR
ASLRLKPRAS TEEGPSEEVA EEKSYQCELT VDDVMPAVKT VIRSVRILKF LVAKRKFKET
LRPYDVKDVI EQYSAGHLDM LGRIKSLQAR VDQIVGRGPG DRKAREKGDK GPSDTEAVDE
ISMMGRVVKV EKQVQSIEHK LDLLLGFYSR CLRSGTSASL GTVQVPLFDP DITSDYHSPV
DHEDISVSAQ TLSISRSVST NMD
//
