ID   A0A340X5L9_LIPVE        Unreviewed;       641 AA.
AC   A0A340X5L9;
DT   10-OCT-2018, integrated into UniProtKB/TrEMBL.
DT   10-OCT-2018, sequence version 1.
DT   27-MAR-2024, entry version 27.
DE   RecName: Full=Kinetochore protein NDC80 {ECO:0000256|RuleBase:RU368072};
GN   Name=NDC80 {ECO:0000313|RefSeq:XP_007456616.1};
OS   Lipotes vexillifer (Yangtze river dolphin).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Whippomorpha; Cetacea; Odontoceti;
OC   Lipotidae; Lipotes.
OX   NCBI_TaxID=118797 {ECO:0000313|Proteomes:UP000265300, ECO:0000313|RefSeq:XP_007456616.1};
RN   [1] {ECO:0000313|RefSeq:XP_007456616.1}
RP   IDENTIFICATION.
RG   RefSeq;
RL   Submitted (NOV-2023) to UniProtKB.
CC   -!- FUNCTION: Acts as a component of the essential kinetochore-associated
CC       NDC80 complex, which is required for chromosome segregation and spindle
CC       checkpoint activity. {ECO:0000256|RuleBase:RU368072}.
CC   -!- SUBUNIT: Component of the NDC80 complex.
CC       {ECO:0000256|RuleBase:RU368072}.
CC   -!- SUBCELLULAR LOCATION: Chromosome, centromere, kinetochore
CC       {ECO:0000256|RuleBase:RU368072}. Nucleus
CC       {ECO:0000256|RuleBase:RU368072}.
CC   -!- SIMILARITY: Belongs to the NDC80/HEC1 family.
CC       {ECO:0000256|ARBA:ARBA00007050, ECO:0000256|RuleBase:RU368072}.
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DR   RefSeq; XP_007456616.1; XM_007456554.1.
DR   AlphaFoldDB; A0A340X5L9; -.
DR   STRING; 118797.A0A340X5L9; -.
DR   GeneID; 103086819; -.
DR   KEGG; lve:103086819; -.
DR   CTD; 10403; -.
DR   InParanoid; A0A340X5L9; -.
DR   OrthoDB; 25325at2759; -.
DR   Proteomes; UP000265300; Unplaced.
DR   GO; GO:0031262; C:Ndc80 complex; IEA:UniProtKB-UniRule.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0051315; P:attachment of mitotic spindle microtubules to kinetochore; IEA:UniProtKB-UniRule.
DR   GO; GO:0051301; P:cell division; IEA:UniProtKB-UniRule.
DR   Gene3D; 6.10.250.1950; -; 1.
DR   Gene3D; 1.10.418.30; Ncd80 complex, Ncd80 subunit; 1.
DR   InterPro; IPR040967; DUF5595.
DR   InterPro; IPR005550; Kinetochore_Ndc80.
DR   InterPro; IPR038273; Ndc80_sf.
DR   PANTHER; PTHR10643; KINETOCHORE PROTEIN NDC80; 1.
DR   PANTHER; PTHR10643:SF2; KINETOCHORE PROTEIN NDC80 HOMOLOG; 1.
DR   Pfam; PF18077; DUF5595; 1.
DR   Pfam; PF03801; Ndc80_HEC; 1.
PE   3: Inferred from homology;
KW   Cell cycle {ECO:0000256|ARBA:ARBA00023306, ECO:0000256|RuleBase:RU368072};
KW   Cell division {ECO:0000256|ARBA:ARBA00022618,
KW   ECO:0000256|RuleBase:RU368072};
KW   Centromere {ECO:0000256|ARBA:ARBA00023328, ECO:0000256|RuleBase:RU368072};
KW   Chromosome {ECO:0000256|ARBA:ARBA00022454, ECO:0000256|RuleBase:RU368072};
KW   Coiled coil {ECO:0000256|ARBA:ARBA00023054, ECO:0000256|SAM:Coils};
KW   Kinetochore {ECO:0000256|ARBA:ARBA00022838, ECO:0000256|RuleBase:RU368072};
KW   Mitosis {ECO:0000256|ARBA:ARBA00022776, ECO:0000256|RuleBase:RU368072};
KW   Nucleus {ECO:0000256|ARBA:ARBA00023242, ECO:0000256|RuleBase:RU368072};
KW   Reference proteome {ECO:0000313|Proteomes:UP000265300}.
FT   DOMAIN          212..284
FT                   /note="DUF5595"
FT                   /evidence="ECO:0000259|Pfam:PF18077"
FT   REGION          24..70
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COILED          239..399
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COILED          464..569
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COMPBIAS        24..50
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   641 AA;  73662 MW;  474FD94DB4D8D305 CRC64;
     MKRSSFSTGG AGRLSMQELR SQDLNKPGLH TPQTKEKTFG KLNINKPTSE RKASVFGKRT
     SGHGSRNSQF GIFSTSEKIK DPRPLNDKAF IQQCIRQLCE FLSENGYAYS VSMKSLQAPS
     VKDFLKIFTF LYGFLCPSYE LPDTKFEEEV PRIFKDLGYP FALSKSSMYT VGAPHTWPHI
     VAALVWLIDC IKLHNAMKES SPLFDDGQPW GEETEDGIMH NKLFLDYTIK CYESFMTGAD
     SFEEMNAELQ SRLKDLFNVD ASKLESLAAK NRALNEQIAR LEQEREKEPN RLESLRKLKA
     SLQADVQKYQ AYMSNLESHS AILDQKLNGL DEEISRVELE CETMKQENSR LQNIVDNQKY
     SVADIERINH ERNELQQTIN KLTKDLEAEQ QQLWNEELKY ARGKEAIETQ LAEYHKLARK
     LKLIPKGAEN SKGYDFEIKF NPEAGANCLV KYRAQVYVPL KELLNQTEEE TNKALNKKMG
     LEDTLEQLNT MITESRRSVR TLKEEVQKLD DLHQQKVKEA EEEDKKCANE LESLEKHKHL
     LESAVNEGLS EAMNELDAIQ RECQLVVQTT TEERRKVGNN LQRLLEMVAT HVGSVEKHLE
     EQIAKADREY EEYTSEDLLD NIREIGDKYK KKAALLKASD E
//